PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
23098168-0	2012	Jatrophane diterpenes from Euphorbia mellifera and their activity as P-glycoprotein modulators on multidrug-resistant mouse lymphoma and human colon adenocarcinoma cells.	Diterpenes	11-21	ATP binding cassette subfamily B member 1	Homo sapiens	69-83	
27328029-0	2016	Jatrophane Diterpenoids as Modulators of P-Glycoprotein-Dependent Multidrug Resistance (MDR): Advances of Structure-Activity Relationships and Discovery of Promising MDR Reversal Agents.	Diterpenes	11-23	ATP binding cassette subfamily B member 1	Homo sapiens	41-55	
23228414-0	2013	QSAR studies of macrocyclic diterpenes with P-glycoprotein inhibitory activity.	Diterpenes	28-38	ATP binding cassette subfamily B member 1	Homo sapiens	44-58	
23228414-5	2013	In this study we applied quantitative structure-activity relationship (QSAR) methodology in order to identify the most relevant molecular features of macrocyclic diterpenes with P-gp inhibitory activity and to determine which structural modifications can be performed to improve their activity.	Diterpenes	162-172	ATP binding cassette subfamily B member 1	Homo sapiens	178-182	
29407947-0	2018	Jatrophane diterpenoids from Euphorbia sororia as potent modulators against P-glycoprotein-based multidrug resistance.	Diterpenes	11-23	ATP binding cassette subfamily B member 1	Homo sapiens	76-90	
27240278-0	2016	neo-Clerodane diterpenoids from Scutellaria barbata mediated inhibition of P-glycoprotein in MCF-7/ADR cells.	Diterpenes	14-26	ATP binding cassette subfamily B member 1	Homo sapiens	75-89	
25371982-5	2014	The MDR reversal potential of macrocyclic diterpenes 3-5 was evaluated through a drug combination assay, using the L5178Y mouse T lymphoma cell line transfected with the human MDR1 gene.	Diterpenes	42-52	ATP binding cassette subfamily B member 1	Homo sapiens	176-180	
23098168-4	2012	Jatrophane diterpenes 1-3 and 5 were evaluated for their effects on the reversion of multidrug resistance (MDR) mediated by P-glycoprotein, by using the rhodamine-123 exclusion test, on human MDR1 gene-transfected mouse lymphoma cells (L5178Y MDR) and on human colon adenocarcinoma cells (COLO 320).	Diterpenes	11-21	ATP binding cassette subfamily B member 1	Homo sapiens	124-138	
32292314-3	2020	Among macrocyclic diterpenes of Euphorbia, the discovery of jatrophane and modified jatrophane diterpenes with a wide range of structurally unique polyoxygenated polycyclic derivatives and as a new class of powerful inhibitors of P-glycoprotein has opened new frontiers for research studies on this genus.	Diterpenes	18-28	ATP binding cassette subfamily B member 1	Homo sapiens	230-244	
21604687-0	2011	Toward a better pharmacophore description of P-glycoprotein modulators, based on macrocyclic diterpenes from Euphorbia species.	Diterpenes	93-103	ATP binding cassette subfamily B member 1	Homo sapiens	45-59	
8094975-10	1993	These results indicate that the diterpenes modulate VBL sensitivity predominantly by inhibiting PGP-mediated efflux activity.	Diterpenes	32-42	ATP binding cassette subfamily B member 1	Homo sapiens	96-99	
34742027-0	2021	Diterpenoids from Euphorbia glomerulans with potential reversal activities against P-glycoprotein-mediated multidrug resistance.	Diterpenes	0-12	ATP binding cassette subfamily B member 1	Homo sapiens	83-97	
35450348-0	2022	C20-nor-Abietane and Three Abietane Diterpenoids from Plectranthus mutabilis Leaves as P-Glycoprotein Modulators.	Diterpenes	36-48	ATP binding cassette subfamily B member 1	Homo sapiens	87-101	
32292314-3	2020	Among macrocyclic diterpenes of Euphorbia, the discovery of jatrophane and modified jatrophane diterpenes with a wide range of structurally unique polyoxygenated polycyclic derivatives and as a new class of powerful inhibitors of P-glycoprotein has opened new frontiers for research studies on this genus.	Diterpenes	95-105	ATP binding cassette subfamily B member 1	Homo sapiens	230-244