PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 24358331-0 2013 A pseudopterane diterpene isolated from the octocoral Pseudopterogorgia acerosa inhibits the inflammatory response mediated by TLR-ligands and TNF-alpha in macrophages. Diterpenes 16-25 tumor necrosis factor Mus musculus 143-152 24358331-3 2013 In this study we investigated the anti-inflammatory effects of a known pseudopterane diterpene (referred here as compound 1) isolated from the octocoral Pseudopterogorgia acerosa on the tumor necrosis factor- alpha (TNF-alpha) and TLRs- induced response in macrophages. Diterpenes 85-94 tumor necrosis factor Mus musculus 216-225 18512813-11 2008 Production of tumor necrosis factor, interleukin-6, and monocyte chemoattractant protein 1 by spleen cells was also decreased after diterpenoid therapy. Diterpenes 132-143 tumor necrosis factor Mus musculus 14-35 23609581-4 2013 The results revealed that cembrane-type diterpenoids, especially lobocrassin B, effectively inhibited LPS-induced BMDC activation by inhibiting the production of TNF-alpha. Diterpenes 40-52 tumor necrosis factor Mus musculus 162-171 20822783-0 2010 TNF-alpha inhibitory diterpenoids from the Chinese mangrove plant Excoecaria agallocha L. Chemical examination of the stems and twigs of the mangrove plant Excoecaria agallocha L. resulted in the isolation of six ent-kaurane diterpenoids named agallochaols K-P (1-6), an atisane-type diterpenoid agallochaol Q (7), along with eight known diterpenoids (8-15). Diterpenes 21-33 tumor necrosis factor Mus musculus 0-9 20822783-0 2010 TNF-alpha inhibitory diterpenoids from the Chinese mangrove plant Excoecaria agallocha L. Chemical examination of the stems and twigs of the mangrove plant Excoecaria agallocha L. resulted in the isolation of six ent-kaurane diterpenoids named agallochaols K-P (1-6), an atisane-type diterpenoid agallochaol Q (7), along with eight known diterpenoids (8-15). Diterpenes 225-237 tumor necrosis factor Mus musculus 0-9 20822783-0 2010 TNF-alpha inhibitory diterpenoids from the Chinese mangrove plant Excoecaria agallocha L. Chemical examination of the stems and twigs of the mangrove plant Excoecaria agallocha L. resulted in the isolation of six ent-kaurane diterpenoids named agallochaols K-P (1-6), an atisane-type diterpenoid agallochaol Q (7), along with eight known diterpenoids (8-15). Diterpenes 21-32 tumor necrosis factor Mus musculus 0-9 20822783-0 2010 TNF-alpha inhibitory diterpenoids from the Chinese mangrove plant Excoecaria agallocha L. Chemical examination of the stems and twigs of the mangrove plant Excoecaria agallocha L. resulted in the isolation of six ent-kaurane diterpenoids named agallochaols K-P (1-6), an atisane-type diterpenoid agallochaol Q (7), along with eight known diterpenoids (8-15). Diterpenes 225-237 tumor necrosis factor Mus musculus 0-9 12612453-0 2003 Inhibitory effect of norditerpenes on LPS-induced TNF-alpha production from the Okinawan soft coral, Sinularia sp. Diterpenes 21-34 tumor necrosis factor Mus musculus 50-59 18190942-3 2008 These diterpenoids reduced the production of nitric oxide (NO), prostaglandin E2, and tumor necrosis factor-alpha in LPS-activated RAW 264.7 macrophages, with IC50 in the range 1-10 microM. Diterpenes 6-18 tumor necrosis factor Mus musculus 64-113 29680963-4 2018 The anti-inflammatory and anti-angiogenic activities of eight diterpenoids were evaluated on LPS-induced macrophage RAW264.7 cells and TNF-alpha-stimulated human umbilical vein endothelial cells (HUVECs) using hierarchical cluster analysis (HCA) and principal component analysis (PCA). Diterpenes 62-74 tumor necrosis factor Mus musculus 135-144 7901279-2 1993 Three lines of evidence support this hypothesis: a) Taxol, a microtubule-binding diterpene, mimics the ability of LPS to induce cytokines and down-regulate receptors for TNF-alpha. Diterpenes 81-90 tumor necrosis factor Mus musculus 170-179 33413289-15 2021 The diterpenes DEOX, ICT, and DAM decreased levels of NO (38.34, 47.63, 67.15%), IL-6 (57.84, 60.45, 44.26%), and TNF-alpha (38.90, 31.30, 32.83%), respectively. Diterpenes 4-14 tumor necrosis factor Mus musculus 114-123 33413289-18 2021 Furthermore, the diterpenes DEOX, DAM, and ICT showed anti-inflammatory activity by reducing levels of NO, TNF-alpha, and IL-6. Diterpenes 17-27 tumor necrosis factor Mus musculus 107-116 30114517-8 2018 Moreover, the inhibitory effect on mRNA expression of proinflammatory cytokine IL-1beta, IL-6 and TNF-alpha of fourteen cassane diterpenes obtained from CMC extract were valued using the RAW 264.7 macrophages cell stimulated by lipopolysaccharide (LPS) assay. Diterpenes 128-138 tumor necrosis factor Mus musculus 98-107 29680963-6 2018 All the eight diterpenes significantly down-regulated the excessive secretion of TNF-alpha, IL-6, IL-1beta and NO in LPS-induced RAW264.7 macrophages. Diterpenes 14-24 tumor necrosis factor Mus musculus 81-90 29680963-10 2018 In conclusion, eight diterpenes isolated from D. genkwa showed different levels of activity in LPS-induced RAW264.7 cells and TNF-alpha-stimulated HUVECs. Diterpenes 21-31 tumor necrosis factor Mus musculus 126-135 27154204-5 2016 Consistent with this result, DT pre-treatment inhibited nuclear factor kappaB (NF-kappaB) nuclear translocation, by interfering with IkappaBalpha phosphorylation, and consequently NF-kappaB transcriptional activity in endothelium activated by LPS or TNF-alpha. Diterpenes 29-31 tumor necrosis factor Mus musculus 250-259 27154204-4 2016 Lung endothelial cells pre-treated with DT and activated with lipopolysaccharide (LPS) or tumour necrosis factor-alpha (TNF-alpha) exhibited reduced expression of the pro-inflammatory cytokines Cxcl10, Ccl5 and Cxcl1, whereas the anti-inflammatory molecules IL1r2 and IL-10 were induced. Diterpenes 40-42 tumor necrosis factor Mus musculus 120-129 27154204-12 2016 Our findings establish DT as a novel endothelial inhibitor for the treatment of inflammatory-related diseases triggered by Gram-negative bacteria or by the associated cytokine TNF-alpha. Diterpenes 23-25 tumor necrosis factor Mus musculus 176-185