PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
23129237-2	2013	In this             study, we found that JB, a diterpenoid from the traditional Chinese medicinal             herb, strongly inhibited the PI3K/Akt/mTOR signaling pathway.	Diterpenes	47-58	AKT serine/threonine kinase 1	Homo sapiens	144-147	
19768546-0	2009	The coffee diterpene kahweol induces apoptosis in human leukemia U937 cells through down-regulation of Akt phosphorylation and activation of JNK.	Diterpenes	11-20	AKT serine/threonine kinase 1	Homo sapiens	103-106	
24009843-0	2012	Anticancer Activity of Novel Daphnane Diterpenoids from Daphne genkwa through Cell-Cycle Arrest and Suppression of Akt/STAT/Src Signalings in Human Lung Cancer Cells.	Diterpenes	38-50	AKT serine/threonine kinase 1	Homo sapiens	115-118	
24009843-7	2012	In the analysis of signal transduction molecules, the daphnane diterpenoids suppressed the activation of Akt, STAT3 and Src in human lung cancer cells.	Diterpenes	63-75	AKT serine/threonine kinase 1	Homo sapiens	105-108	
33417145-0	2021	Ent-kaurane-type diterpenoids from Isodonis Herba activate human hair follicle dermal papilla cells proliferation via the Akt/GSK-3beta/beta-catenin transduction pathway.	Diterpenes	17-29	AKT serine/threonine kinase 1	Homo sapiens	122-125	
33762565-0	2021	Retracted: Ferruginol Diterpenoid Selectively Inhibits Human Thyroid Cancer Growth by Inducing Mitochondrial Dependent Apoptosis, Endogenous Reactive Oxygen Species (ROS) Production, Mitochondrial Membrane Potential Loss and Suppression of Mitogen-Activated Protein Kinase (MAPK) and PI3K/AKT Signaling Pathways.	Diterpenes	22-33	AKT serine/threonine kinase 1	Homo sapiens	289-292	
27639426-6	2016	Andrographolide, a natural diterpenoid, promoted the activation of the Akt/mTOR signaling by downregulating PTEN and suppressed autophagy, which subsequently resensitized the resistant cells to cisplatin-mediated apoptosis.	Diterpenes	27-38	AKT serine/threonine kinase 1	Homo sapiens	71-74	
32223193-0	2020	Daphnane Diterpenoids from Daphne genkwa Inhibit PI3K/Akt/mTOR Signaling and Induce Cell Cycle Arrest and Apoptosis in Human Colon Cancer Cells.	Diterpenes	9-21	AKT serine/threonine kinase 1	Homo sapiens	54-57	
30358211-0	2018	Royleanone diterpenoid exhibits potent anticancer effects in LNCaP human prostate carcinoma cells by inducing mitochondrial mediated apoptosis, cell cycle arrest, suppression of cell migration and downregulation of mTOR/PI3K/AKT signalling pathway.	Diterpenes	11-22	AKT serine/threonine kinase 1	Homo sapiens	225-228	
24044886-0	2013	A diterpenoid compound, excisanin A, inhibits the invasive behavior of breast cancer cells by modulating the integrin beta1/FAK/PI3K/AKT/beta-catenin signaling.	Diterpenes	2-13	AKT serine/threonine kinase 1	Homo sapiens	133-136