PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 25438763-1 2014 Aiming to optimize macrocyclic lathyrane-type diterpenes as effective Pgp modulators, the phytochemical study of the methanolic extract of Euphorbia boetica aerial parts was carried out. Diterpenes 46-56 phosphoglycolate phosphatase Homo sapiens 70-73 23336337-4 2013 In this small library of novel bioactive macrocyclic lathyrane diterpene derivatives, designed to evaluate structure-activity relationships essential in overcoming multidrug resistance (MDR), some correlations between MDR reversal and molecular weight, accessible solvent areas, and octanol/water partition coefficient were identified that can contribute to the development of new selective P-gp reversal agents. Diterpenes 63-72 phosphoglycolate phosphatase Homo sapiens 391-395 18824363-4 2008 The molecular orbital energies (HOMO and LUMO) of diterpenes 1-6 and 7-13, previously isolated, have also been calculated in order to estimate their probable charge transfer interactions with P-gp. Diterpenes 50-60 phosphoglycolate phosphatase Homo sapiens 192-196