PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
21219911-7	2011	KEY FINDINGS: Both diterpenoids inhibited the mRNA and protein expressions of CYP1A2, CYP2D6, and CYP3A4.	Diterpenes	19-31	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	98-104	
21219911-8	2011	Interestingly, the lowest concentration of both diterpenoids produced a more than 50% reduction in the mRNA and protein expression of CYP3A4 and this reduction was consistent with the enzyme activity.	Diterpenes	48-60	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	134-140	
21219911-9	2011	Further experiments revealed that both diterpenoids were also capable of attenuating the ability of dexamethasone to induce CYP3A4 expression, and 14-Deoxy-11, 12-Didehydroandrographolide tended to bind to the PXR-LBD site in a concentration-dependent manner.	Diterpenes	39-51	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	124-130	
21219911-10	2011	SIGNIFICANCE: These diterpenoids are potential CYP3A4 inhibitors and the effects on CYP3A4 may be clinically significant.	Diterpenes	20-32	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	47-53	
21219911-10	2011	SIGNIFICANCE: These diterpenoids are potential CYP3A4 inhibitors and the effects on CYP3A4 may be clinically significant.	Diterpenes	20-32	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	84-90	
19795923-4	2009	In human liver microsomes, 7-epi-cephalomannine was subject to C-13 lateral chain (M-1) and diterpenoid core monohydroxylation (M-2), mediated by cytochrome P450 (CYP) 3A4 and CYP2C8, respectively.	Diterpenes	92-103	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	146-171	
14672753-7	2004	Extensive pulegone metabolism generated p-cresol that was a glutathione depletory, and the furan ring of the diterpenoids in germander was oxidized by CYP3A4 to reactive epoxide which reacts with proteins such as CYP3A and epoxide hydrolase.	Diterpenes	109-121	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	151-157