PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 34394903-8 2021 KDM4C upregulation promoted the demethylation in the promoter region of MALAT1 to increase its expression, MALAT1 targeted and inhibited miR-328-3p expression, enhancing the Ara-C resistance of HL-60/A. Cytarabine 174-179 metastasis associated lung adenocarcinoma transcript 1 (non-coding RNA) Mus musculus 72-78 34394903-0 2021 KDM4C contributes to cytarabine resistance in acute myeloid leukemia via regulating the miR-328-3p/CCND2 axis through MALAT1. Cytarabine 21-31 metastasis associated lung adenocarcinoma transcript 1 (non-coding RNA) Mus musculus 118-124 34394903-2 2021 In this study, we aimed to investigate the molecular mechanism of KDM4C-dependent MALAT1/miR-328-3p/CCND2 axis in cytarabine (Ara-C) resistance in the context of AML. Cytarabine 114-124 metastasis associated lung adenocarcinoma transcript 1 (non-coding RNA) Mus musculus 82-88 34394903-2 2021 In this study, we aimed to investigate the molecular mechanism of KDM4C-dependent MALAT1/miR-328-3p/CCND2 axis in cytarabine (Ara-C) resistance in the context of AML. Cytarabine 126-131 metastasis associated lung adenocarcinoma transcript 1 (non-coding RNA) Mus musculus 82-88 34394903-8 2021 KDM4C upregulation promoted the demethylation in the promoter region of MALAT1 to increase its expression, MALAT1 targeted and inhibited miR-328-3p expression, enhancing the Ara-C resistance of HL-60/A. Cytarabine 174-179 metastasis associated lung adenocarcinoma transcript 1 (non-coding RNA) Mus musculus 107-113 34394903-10 2021 Mechanistically, KDM4C regulated miR-328-3p/CCND2 through MALAT1, resulting in Ara-C resistance in AML. Cytarabine 79-84 metastasis associated lung adenocarcinoma transcript 1 (non-coding RNA) Mus musculus 58-64 34394903-11 2021 Findings in an in vivo xenograft NOD/SCID mouse model further confirmed the contribution of KDM4C/MALAT1/miR-328-3p/CCND2 in the Ara-C resistant AML. Cytarabine 129-134 metastasis associated lung adenocarcinoma transcript 1 (non-coding RNA) Mus musculus 98-104