PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 34413167-2 2021 Accumulating evidence has shown that the cystathionine beta-synthase/hydrogen sulfide (CBS/H2S) axis is involved in the regulation of inflammation. Hydrogen Sulfide 69-85 cystathionine beta-synthase Mus musculus 41-68 34413167-2 2021 Accumulating evidence has shown that the cystathionine beta-synthase/hydrogen sulfide (CBS/H2S) axis is involved in the regulation of inflammation. Hydrogen Sulfide 69-85 cystathionine beta-synthase Mus musculus 87-90 31283913-4 2019 129P2-Cbstm1Unc/J mice with heterozygous mutants in H2S generating enzyme cystathionine beta-synthase were used to study the effect of endogenous H2S. Hydrogen Sulfide 52-55 cystathionine beta-synthase Mus musculus 74-101 30799778-0 2019 Cystathionine beta-Synthase-Derived Hydrogen Sulfide Correlates with Successful Aging in Mice. Hydrogen Sulfide 36-52 cystathionine beta-synthase Mus musculus 0-27 31349040-9 2019 Inhibition of H2S-synthesizing enzymes, cystathionine-gamma-lyase (CSE) and cystathionine-beta-synthase (CBS), by pretreating cells with propargylglycine (PAG) and oxyaminoacetic acid (AOAA) revealed that H2S production was partially dependent on a CSE/CBS-catalyzed beta-elimination reaction with CySSPe that likely produced 1-propenyl persulfide (RSSH). Hydrogen Sulfide 14-17 cystathionine beta-synthase Mus musculus 76-103 31349040-9 2019 Inhibition of H2S-synthesizing enzymes, cystathionine-gamma-lyase (CSE) and cystathionine-beta-synthase (CBS), by pretreating cells with propargylglycine (PAG) and oxyaminoacetic acid (AOAA) revealed that H2S production was partially dependent on a CSE/CBS-catalyzed beta-elimination reaction with CySSPe that likely produced 1-propenyl persulfide (RSSH). Hydrogen Sulfide 205-208 cystathionine beta-synthase Mus musculus 76-103 33318875-14 2021 Our study suggests that the regulation of Runx2 by hydrogen sulfide (CSE/CBS) occurs via NF-kappaB establishing a link between inflammation and mineralization in vascular calcification. Hydrogen Sulfide 51-67 cystathionine beta-synthase Mus musculus 73-76 30835815-1 2020 BACKGROUND AND PURPOSE: Among the three enzymes involved in the transsulfuration pathway, only cystathionine beta-synthase (CBS) converts L-cysteine into L-serine and H2 S. Hydrogen Sulfide 167-171 cystathionine beta-synthase Mus musculus 95-122 30835815-1 2020 BACKGROUND AND PURPOSE: Among the three enzymes involved in the transsulfuration pathway, only cystathionine beta-synthase (CBS) converts L-cysteine into L-serine and H2 S. Hydrogen Sulfide 167-171 cystathionine beta-synthase Mus musculus 124-127 31119834-2 2019 H2 S production in colon is yielded by cystathionine beta-synthase (CBS) and cystathionine gamma-lyase (CSE) enzymes and sulfate-reducing bacteria (SRB). Hydrogen Sulfide 0-4 cystathionine beta-synthase Mus musculus 39-66 31119834-2 2019 H2 S production in colon is yielded by cystathionine beta-synthase (CBS) and cystathionine gamma-lyase (CSE) enzymes and sulfate-reducing bacteria (SRB). Hydrogen Sulfide 0-4 cystathionine beta-synthase Mus musculus 68-71 30036087-4 2019 Inhibition of both cystathionine-gamma-lyase (CSE) and cystathionine-beta-synthase (CBS), 2 major enzymes for endogenous H2S production, with propargylglycine (PPG) and amino-oxyacetate (AOAA), respectively, caused increased urine output and reduced urine osmolality in mice that was associated with decreased expression of aquaporin (AQP)-2 in the renal inner medulla. Hydrogen Sulfide 121-124 cystathionine beta-synthase Mus musculus 55-82 31440142-4 2019 We found that endogenous H2S production was downregulated in the brain after ICH, which is caused by the decrease in cystathionine beta-synthase (CBS) as the predominant cerebral H2S-generating enzyme in the brain. Hydrogen Sulfide 25-28 cystathionine beta-synthase Mus musculus 117-144 31440142-4 2019 We found that endogenous H2S production was downregulated in the brain after ICH, which is caused by the decrease in cystathionine beta-synthase (CBS) as the predominant cerebral H2S-generating enzyme in the brain. Hydrogen Sulfide 25-28 cystathionine beta-synthase Mus musculus 146-149 31440142-4 2019 We found that endogenous H2S production was downregulated in the brain after ICH, which is caused by the decrease in cystathionine beta-synthase (CBS) as the predominant cerebral H2S-generating enzyme in the brain. Hydrogen Sulfide 179-182 cystathionine beta-synthase Mus musculus 117-144 31440142-4 2019 We found that endogenous H2S production was downregulated in the brain after ICH, which is caused by the decrease in cystathionine beta-synthase (CBS) as the predominant cerebral H2S-generating enzyme in the brain. Hydrogen Sulfide 179-182 cystathionine beta-synthase Mus musculus 146-149 31440142-5 2019 Treatment with sodium hydrosulfide (NaHS; an H2S producer) could restore the H2S production and the expression of CBS. Hydrogen Sulfide 45-48 cystathionine beta-synthase Mus musculus 114-117 31440142-9 2019 We also found that AOAA reduced the endogenous H2S production through inhibiting the enzyme activity of CBS rather than modulating the expression of CBS protein level. Hydrogen Sulfide 47-50 cystathionine beta-synthase Mus musculus 104-107 31025223-4 2019 Biochemically, there was increase in the plasma levels of endothelin-1 along with increase in the brain levels of H2S and its biosynthetic enzymes viz., cystathionine-beta-synthase (CBS) and cystathionine-gamma-lyase (CLS). Hydrogen Sulfide 114-117 cystathionine beta-synthase Mus musculus 153-180 30859447-1 2019 Murine macrophages of the J774A.1 line are hydrogen sulphide-producing cells with the primary role of gamma-cystathionase (CTH) and secondary role of 3-mercaptopyruvate sulfurtransferase (limited by cysteine availability) and with a negligible role of cystathionine beta-synthase (CBS) in H2S generation. Hydrogen Sulfide 43-60 cystathionine beta-synthase Mus musculus 252-279 30862476-3 2019 Therefore we assessed the expressional kinetics of potential H2S-producing enzymes during undisturbed skin repair: the cystathionine-gamma-lyase (CSE), the cystathionine-beta-synthase (CBS) and the 3-mercaptopyruvate sulfurtransferase (MPST). Hydrogen Sulfide 61-64 cystathionine beta-synthase Mus musculus 185-188 30683311-2 2019 Cystathionine-beta-synthase (CBS), an H2S-generating enzyme in methionine metabolism, regulates the function of these EPCs. Hydrogen Sulfide 38-41 cystathionine beta-synthase Mus musculus 0-27 30683311-2 2019 Cystathionine-beta-synthase (CBS), an H2S-generating enzyme in methionine metabolism, regulates the function of these EPCs. Hydrogen Sulfide 38-41 cystathionine beta-synthase Mus musculus 29-32 30534696-7 2019 Meanwhile, the decreased cystathionine beta synthase (CBS, an endogenous hydrogen sulfide (H2S) synthetase) level was also observed in H22-bearing mice admistrated with the combination of curcuma zedoary and kelp. Hydrogen Sulfide 73-89 cystathionine beta-synthase Mus musculus 25-52 30534696-7 2019 Meanwhile, the decreased cystathionine beta synthase (CBS, an endogenous hydrogen sulfide (H2S) synthetase) level was also observed in H22-bearing mice admistrated with the combination of curcuma zedoary and kelp. Hydrogen Sulfide 73-89 cystathionine beta-synthase Mus musculus 54-57 30534696-10 2019 Our previous research showed that a CBS/H2S system was vital for maintaining the proliferation in hepatoma cells. Hydrogen Sulfide 40-43 cystathionine beta-synthase Mus musculus 36-39 31131233-0 2019 Hydrogen sulfide intervention in cystathionine-beta-synthase mutant mouse helps restore ocular homeostasis. Hydrogen Sulfide 0-16 cystathionine beta-synthase Mus musculus 33-60 30036087-4 2019 Inhibition of both cystathionine-gamma-lyase (CSE) and cystathionine-beta-synthase (CBS), 2 major enzymes for endogenous H2S production, with propargylglycine (PPG) and amino-oxyacetate (AOAA), respectively, caused increased urine output and reduced urine osmolality in mice that was associated with decreased expression of aquaporin (AQP)-2 in the renal inner medulla. Hydrogen Sulfide 121-124 cystathionine beta-synthase Mus musculus 84-87 29998554-2 2018 Cystathionine beta-synthase (CBS) and cystathionine gamma-lyase (CSE) are the major enzymes responsible for H2 S production through desulfuration reactions. Hydrogen Sulfide 108-112 cystathionine beta-synthase Mus musculus 0-27 29486221-5 2018 The H2S-generating enzyme cystathionine-beta-synthase (CBS) knockout heterozygous (CBS+/-) mice showed mitochondria-mediated apoptosis in the adrenal gland and adrenal insufficiency. Hydrogen Sulfide 4-7 cystathionine beta-synthase Mus musculus 26-53 29486221-5 2018 The H2S-generating enzyme cystathionine-beta-synthase (CBS) knockout heterozygous (CBS+/-) mice showed mitochondria-mediated apoptosis in the adrenal gland and adrenal insufficiency. Hydrogen Sulfide 4-7 cystathionine beta-synthase Mus musculus 55-58 29486221-5 2018 The H2S-generating enzyme cystathionine-beta-synthase (CBS) knockout heterozygous (CBS+/-) mice showed mitochondria-mediated apoptosis in the adrenal gland and adrenal insufficiency. Hydrogen Sulfide 4-7 cystathionine beta-synthase Mus musculus 83-86 30175474-0 2018 Hydrogen sulfide improves postischemic neoangiogenesis in the hind limb of cystathionine-beta-synthase mutant mice via PPAR-gamma/VEGF axis. Hydrogen Sulfide 0-16 cystathionine beta-synthase Mus musculus 75-102 29998554-2 2018 Cystathionine beta-synthase (CBS) and cystathionine gamma-lyase (CSE) are the major enzymes responsible for H2 S production through desulfuration reactions. Hydrogen Sulfide 108-112 cystathionine beta-synthase Mus musculus 29-32 29730290-1 2018 Hydrogen sulfide (H2S), a gaseous signaling molecule produced by cystathionine gamma-lyase (CSE) and cystathionine beta-synthase (CBS), influences bone remodeling in many ways. Hydrogen Sulfide 0-16 cystathionine beta-synthase Mus musculus 101-128 29730290-1 2018 Hydrogen sulfide (H2S), a gaseous signaling molecule produced by cystathionine gamma-lyase (CSE) and cystathionine beta-synthase (CBS), influences bone remodeling in many ways. Hydrogen Sulfide 18-21 cystathionine beta-synthase Mus musculus 101-128 28982640-1 2018 Hydrogen sulfide (H2S) is an endogenously produced signaling molecule synthesized by cystathionine gamma-lyase (CSE), cystathionine beta-synthase (CBS) and 3-mercaptopyruvate sulfurtransferase (3-MST). Hydrogen Sulfide 0-16 cystathionine beta-synthase Mus musculus 118-145 26078817-6 2015 The expression of the H2S-generating enzymes, cystathionine gamma-lyase and 3-mercaptopyruvate sulfurtransferase, was significantly decreased in the hearts of fructose-fed mice, whereas cystathionine-beta-synthase levels were significantly increased. Hydrogen Sulfide 22-25 cystathionine beta-synthase Mus musculus 186-213 27273718-2 2016 Hydrogen sulfide is generated from L-cysteine by cystathionine-beta-synthase (CBS), cystathionine-gamma-lyase (CSE), and/or 3-mercaptopyruvate sulfurtransferase (3-MST). Hydrogen Sulfide 0-16 cystathionine beta-synthase Mus musculus 49-76 27273718-2 2016 Hydrogen sulfide is generated from L-cysteine by cystathionine-beta-synthase (CBS), cystathionine-gamma-lyase (CSE), and/or 3-mercaptopyruvate sulfurtransferase (3-MST). Hydrogen Sulfide 0-16 cystathionine beta-synthase Mus musculus 78-81 26961888-0 2016 Endogenous CBS-H2S Pathway Contributes to the Development of CCI-Induced Neuropathic Pain. Hydrogen Sulfide 15-18 cystathionine beta-synthase Mus musculus 11-14 26961888-2 2016 In this study, the relationship between endogenous CBS-H2S pathway in L4-6 spinal cord and neuropathic pain was explored. Hydrogen Sulfide 55-58 cystathionine beta-synthase Mus musculus 51-54 26961888-8 2016 Correlation analysis showed pain thresholds had negative relationships with protein expression of CBS and H2S formation. Hydrogen Sulfide 106-109 cystathionine beta-synthase Mus musculus 98-101 26961888-9 2016 Treatment with AOAA, a CBS inhibitor, inhibited CCI-induced upregulation of CBS expression and H2S formation (P < 0.05). Hydrogen Sulfide 95-98 cystathionine beta-synthase Mus musculus 23-26 26961888-11 2016 This indicated that CBS-H2S pathway promoted the development of neuropathic pain. Hydrogen Sulfide 24-27 cystathionine beta-synthase Mus musculus 20-23 26961888-12 2016 CBS-H2S pathway could be a promising target for treatment of neuropathic pain. Hydrogen Sulfide 4-7 cystathionine beta-synthase Mus musculus 0-3 26232299-0 2015 The H2S-generating enzymes cystathionine beta-synthase and cystathionine gamma-lyase play a role in vascular development during normal lung alveolarization. Hydrogen Sulfide 4-7 cystathionine beta-synthase Mus musculus 27-54 26232299-4 2015 H2S is endogenously generated by cystathionine beta-synthase (Cbs) and cystathionine gamma-lyase (Cth). Hydrogen Sulfide 0-3 cystathionine beta-synthase Mus musculus 33-60 26232299-4 2015 H2S is endogenously generated by cystathionine beta-synthase (Cbs) and cystathionine gamma-lyase (Cth). Hydrogen Sulfide 0-3 cystathionine beta-synthase Mus musculus 62-65 26232299-10 2015 These data confirm a key role for the H2S-generating enzymes Cbs and Cth in pulmonary vascular development and homeostasis and in lung alveolarization. Hydrogen Sulfide 38-41 cystathionine beta-synthase Mus musculus 61-64 28859237-1 2018 Cystathionine beta-synthase (CBS) catalyzes the transsulfuration pathway and contributes, among other functions, to the generation of hydrogen sulfide. Hydrogen Sulfide 134-150 cystathionine beta-synthase Mus musculus 0-27 28859237-1 2018 Cystathionine beta-synthase (CBS) catalyzes the transsulfuration pathway and contributes, among other functions, to the generation of hydrogen sulfide. Hydrogen Sulfide 134-150 cystathionine beta-synthase Mus musculus 29-32 28859237-2 2018 In view of the exceptionally high expression of CBS in the liver and the common interleukin-6 pathway used in the regulatory systems of hydrogen sulfide and hepcidin, we speculate that CBS is involved in body iron homeostasis. Hydrogen Sulfide 136-152 cystathionine beta-synthase Mus musculus 185-188 28751019-0 2017 The cystathionine beta-synthase/hydrogen sulfide pathway contributes to microglia-mediated neuroinflammation following cerebral ischemia. Hydrogen Sulfide 32-48 cystathionine beta-synthase Mus musculus 4-31 28751019-5 2017 Expression of the H2S synthase cystathionine beta-synthase (CBS) and H2S synthetic activity were rapidly decreased in the ischemic brain tissue following MCAO. Hydrogen Sulfide 18-21 cystathionine beta-synthase Mus musculus 31-58 28751019-5 2017 Expression of the H2S synthase cystathionine beta-synthase (CBS) and H2S synthetic activity were rapidly decreased in the ischemic brain tissue following MCAO. Hydrogen Sulfide 18-21 cystathionine beta-synthase Mus musculus 60-63 28751019-7 2017 Enhancing H2S bioavailability either by overexpressing CBS or by supplementing with exogenous H2S donors promoted a shift in microglial polarization from ischemia-induced pro-inflammatory phenotypes toward anti-inflammatory phenotypes. Hydrogen Sulfide 10-13 cystathionine beta-synthase Mus musculus 55-58 28751019-10 2017 Our results suggested that reduced CBS-H2S-AMPK cascade activity contributed to microglia-mediated neuroinflammation following stroke. Hydrogen Sulfide 39-42 cystathionine beta-synthase Mus musculus 35-38 28751019-11 2017 Targeting the CBS-H2S pathway is a promising therapeutic approach for ischemic stroke. Hydrogen Sulfide 18-21 cystathionine beta-synthase Mus musculus 14-17 28735240-3 2017 L-Cysteine is catalyzed by cystathionine-beta-synthase (CBS) in the brain and sequentially produces endogenous H2S. Hydrogen Sulfide 111-114 cystathionine beta-synthase Mus musculus 56-59 28735240-10 2017 Thus, L-Cysteine exerts neuroprotection against HI-induced injury in neonates via the CBS/H2S pathway, mediated in part by anti-apoptotic effects and reduced oxidative stress and ER stress. Hydrogen Sulfide 90-93 cystathionine beta-synthase Mus musculus 86-89 28623294-0 2017 H2S and homocysteine control a novel feedback regulation of cystathionine beta synthase and cystathionine gamma lyase in cardiomyocytes. Hydrogen Sulfide 0-3 cystathionine beta-synthase Mus musculus 60-87 28623294-1 2017 Hydrogen sulfide (H2S), a cardioprotective gas, is endogenously produced from homocysteine by cystathionine beta synthase (CBS) and cystathionine gamma lyase (CSE) enzymes. Hydrogen Sulfide 0-16 cystathionine beta-synthase Mus musculus 94-121 28623294-1 2017 Hydrogen sulfide (H2S), a cardioprotective gas, is endogenously produced from homocysteine by cystathionine beta synthase (CBS) and cystathionine gamma lyase (CSE) enzymes. Hydrogen Sulfide 0-16 cystathionine beta-synthase Mus musculus 123-126 28623294-1 2017 Hydrogen sulfide (H2S), a cardioprotective gas, is endogenously produced from homocysteine by cystathionine beta synthase (CBS) and cystathionine gamma lyase (CSE) enzymes. Hydrogen Sulfide 18-21 cystathionine beta-synthase Mus musculus 94-121 28623294-1 2017 Hydrogen sulfide (H2S), a cardioprotective gas, is endogenously produced from homocysteine by cystathionine beta synthase (CBS) and cystathionine gamma lyase (CSE) enzymes. Hydrogen Sulfide 18-21 cystathionine beta-synthase Mus musculus 123-126 28623294-3 2017 We hypothesize that homocysteine and H2S regulate CBS and CSE expressions in a dose dependent manner in cardiomyocytes, and CBS deficiency induces cardiac CSE expression. Hydrogen Sulfide 37-40 cystathionine beta-synthase Mus musculus 50-53 28384716-8 2017 Interestingly, levels of H2S were markedly increased in retinas of Mthfr+/- and Cbs+/- mice compared with WT. Hydrogen Sulfide 25-28 cystathionine beta-synthase Mus musculus 80-83 27326921-2 2016 H2S is an endogenous gaseous transmitter with myorelaxant properties predominantly formed from l-cysteine (l-Cys) by cystathionine-beta-synthase (CBS) and cystathionine-gamma-lyase (CSE). Hydrogen Sulfide 0-3 cystathionine beta-synthase Mus musculus 117-144 27326921-2 2016 H2S is an endogenous gaseous transmitter with myorelaxant properties predominantly formed from l-cysteine (l-Cys) by cystathionine-beta-synthase (CBS) and cystathionine-gamma-lyase (CSE). Hydrogen Sulfide 0-3 cystathionine beta-synthase Mus musculus 146-149 27326921-5 2016 We firstly demonstrated that both enzymes, CBS and CSE were expressed, and able to convert l-Cys into H2S in mouse uterus. Hydrogen Sulfide 102-105 cystathionine beta-synthase Mus musculus 43-46 26743682-6 2016 More importantly, it realized the visualization of endogenous H2S generated in cells overexpressing cystathionine beta-synthase (CBS), one of the enzymes responsible for producing endogenous H2S. Hydrogen Sulfide 62-65 cystathionine beta-synthase Mus musculus 100-127 26743682-6 2016 More importantly, it realized the visualization of endogenous H2S generated in cells overexpressing cystathionine beta-synthase (CBS), one of the enzymes responsible for producing endogenous H2S. Hydrogen Sulfide 62-65 cystathionine beta-synthase Mus musculus 129-132 26743682-6 2016 More importantly, it realized the visualization of endogenous H2S generated in cells overexpressing cystathionine beta-synthase (CBS), one of the enzymes responsible for producing endogenous H2S. Hydrogen Sulfide 191-194 cystathionine beta-synthase Mus musculus 100-127 26743682-6 2016 More importantly, it realized the visualization of endogenous H2S generated in cells overexpressing cystathionine beta-synthase (CBS), one of the enzymes responsible for producing endogenous H2S. Hydrogen Sulfide 191-194 cystathionine beta-synthase Mus musculus 129-132 27882191-5 2016 The expression of two known H2S-producing enzymes in kidney, cystathionine gamma-lyase (CSE) and cystathionine-beta-synthase (CBS), decreased significantly during ageing. Hydrogen Sulfide 28-31 cystathionine beta-synthase Mus musculus 97-124 27882191-5 2016 The expression of two known H2S-producing enzymes in kidney, cystathionine gamma-lyase (CSE) and cystathionine-beta-synthase (CBS), decreased significantly during ageing. Hydrogen Sulfide 28-31 cystathionine beta-synthase Mus musculus 126-129 25307719-6 2015 The method presented here allows for evaluating the relative contribution of CBS and CTH to generation of H2S in tissues. Hydrogen Sulfide 106-109 cystathionine beta-synthase Mus musculus 77-80 25659756-3 2015 We concluded that this was due to decreased H2S production by downregulation of CBS and CSE enzymes. Hydrogen Sulfide 44-47 cystathionine beta-synthase Mus musculus 80-83 25659756-8 2015 Dysregulated expression of MMP-9, CBS, CSE, NMDA-R1 and Cxs-40, -43 was also normalized in Akita mice treated with H2S. Hydrogen Sulfide 115-118 cystathionine beta-synthase Mus musculus 34-37 25945238-1 2015 OBJECTIVES: This study was undertaken to investigate the protective effects of vitamin B6, cofactor for cystathionine-gamma lyase and cystathionine-beta synthase (producers of H2S), alone and in combination with L-cysteine, H2S precursor, on indomethacin-, and ethanol-induced gastric lesions in male NMRI mice. Hydrogen Sulfide 176-179 cystathionine beta-synthase Mus musculus 134-161 25435139-2 2014 Here we show that IL-1beta-induced memory impairment in brain is mediated by hydrogen sulfide (H2S) synthesized by cystathionine beta-synthase (CBS). Hydrogen Sulfide 77-93 cystathionine beta-synthase Mus musculus 115-142 25435139-2 2014 Here we show that IL-1beta-induced memory impairment in brain is mediated by hydrogen sulfide (H2S) synthesized by cystathionine beta-synthase (CBS). Hydrogen Sulfide 77-93 cystathionine beta-synthase Mus musculus 144-147 25435139-2 2014 Here we show that IL-1beta-induced memory impairment in brain is mediated by hydrogen sulfide (H2S) synthesized by cystathionine beta-synthase (CBS). Hydrogen Sulfide 95-98 cystathionine beta-synthase Mus musculus 115-142 25435139-2 2014 Here we show that IL-1beta-induced memory impairment in brain is mediated by hydrogen sulfide (H2S) synthesized by cystathionine beta-synthase (CBS). Hydrogen Sulfide 95-98 cystathionine beta-synthase Mus musculus 144-147 24874797-6 2014 A significant reduction in sulphide levels and CBS mRNA expression was observed in the hippocampus of mouse models of lipopolysaccharide-induced neuroinflammation-related diseases, suggesting that decreased levels of endogenous H2S might be involved in the pathogenesis of neuroinflammation-related neurodegenerative diseases. Hydrogen Sulfide 228-231 cystathionine beta-synthase Mus musculus 47-50 25086357-7 2014 Elevating endogenous H2S via CBS over-expression in immortalized microglia not only reduced the expression of pro-inflammatory M1 genes, but also enhanced the anti-inflammatory M2 marker IL-10 production in response to rotenone stimulation as compared to vector-transfected cells. Hydrogen Sulfide 21-24 cystathionine beta-synthase Mus musculus 29-32 25086357-11 2014 Taken together, these results reveal that probably via triggering ROS formation, rotenone suppressed the CBS-H2S pathway and thus promoted microglia polarization toward M1 pro-inflammatory phenotype. Hydrogen Sulfide 109-112 cystathionine beta-synthase Mus musculus 105-108 25008073-0 2014 Hydrogen sulfide-mediated regulation of contractility in the mouse ileum with electrical stimulation: roles of L-cysteine, cystathionine beta-synthase, and K+ channels. Hydrogen Sulfide 0-16 cystathionine beta-synthase Mus musculus 123-150 23470016-12 2013 CBS activity was detected in Muller cells by fluorescent detection of H2S. Hydrogen Sulfide 70-73 cystathionine beta-synthase Mus musculus 0-3 23632630-6 2013 H2S-synthesizing enzymes cystathionine-beta-synthase and cystathionine-gamma-lyase were also diminished. Hydrogen Sulfide 0-3 cystathionine beta-synthase Mus musculus 25-52 22657153-7 2013 I/R reduced the expression and activities of cystathionine-beta-synthase (CBS) and cystathionine-gamma-lyase (CSE), both of which are H(2)S-producing enzymes, in the kidneys. Hydrogen Sulfide 134-139 cystathionine beta-synthase Mus musculus 45-72 24491430-1 2014 Cystathionine beta synthase (CBS) is the main contributor to the production of hydrogen sulfide (H2S) in the brain. Hydrogen Sulfide 79-95 cystathionine beta-synthase Mus musculus 29-32 24491430-1 2014 Cystathionine beta synthase (CBS) is the main contributor to the production of hydrogen sulfide (H2S) in the brain. Hydrogen Sulfide 79-95 cystathionine beta-synthase Mus musculus 0-27 24491430-1 2014 Cystathionine beta synthase (CBS) is the main contributor to the production of hydrogen sulfide (H2S) in the brain. Hydrogen Sulfide 97-100 cystathionine beta-synthase Mus musculus 0-27 24491430-1 2014 Cystathionine beta synthase (CBS) is the main contributor to the production of hydrogen sulfide (H2S) in the brain. Hydrogen Sulfide 97-100 cystathionine beta-synthase Mus musculus 29-32 24491430-5 2014 We hypothesize that CBS/H2S pathway plays an important role in the protection of learning and memory functions in the brain at the level of the hippocampus. Hydrogen Sulfide 24-27 cystathionine beta-synthase Mus musculus 20-23 23846016-1 2013 Hydrogen sulfide (H2S) produced by cystathionine beta-synthase (CBS) and cystathionine gamma-lyase (CSE) in the transsulfuration pathway of homocysteine plays a number of pathophysiological roles. Hydrogen Sulfide 0-16 cystathionine beta-synthase Mus musculus 35-62 23846016-1 2013 Hydrogen sulfide (H2S) produced by cystathionine beta-synthase (CBS) and cystathionine gamma-lyase (CSE) in the transsulfuration pathway of homocysteine plays a number of pathophysiological roles. Hydrogen Sulfide 0-16 cystathionine beta-synthase Mus musculus 64-67 23846016-1 2013 Hydrogen sulfide (H2S) produced by cystathionine beta-synthase (CBS) and cystathionine gamma-lyase (CSE) in the transsulfuration pathway of homocysteine plays a number of pathophysiological roles. Hydrogen Sulfide 18-21 cystathionine beta-synthase Mus musculus 35-62 23846016-1 2013 Hydrogen sulfide (H2S) produced by cystathionine beta-synthase (CBS) and cystathionine gamma-lyase (CSE) in the transsulfuration pathway of homocysteine plays a number of pathophysiological roles. Hydrogen Sulfide 18-21 cystathionine beta-synthase Mus musculus 64-67 22232681-3 2012 In this cascade, hypoxia elicits cerebral vasodilation via the coordinate actions of H(2)S formed by cystathionine beta-synthase (CBS) and CO generated by heme oxygenase (HO)-2. Hydrogen Sulfide 85-90 cystathionine beta-synthase Mus musculus 101-128 23325453-4 2013 Expression of Cystathionine-beta-synthase (CBS) mRNA as H2S-producing enzymes in mouse brain was determined by reverse transcriptase-polymerase chain reaction (RT-PCR). Hydrogen Sulfide 56-59 cystathionine beta-synthase Mus musculus 14-41 23325453-4 2013 Expression of Cystathionine-beta-synthase (CBS) mRNA as H2S-producing enzymes in mouse brain was determined by reverse transcriptase-polymerase chain reaction (RT-PCR). Hydrogen Sulfide 56-59 cystathionine beta-synthase Mus musculus 43-46 23325453-8 2013 Hydrogen sulfide in the cortex and hippocampus exhibited dynamic changes after brain injury, in parallel with CBS mRNA and protein expression. Hydrogen Sulfide 0-16 cystathionine beta-synthase Mus musculus 110-113 22314625-2 2012 The enzymes cystathionine gamma-lyase (CSE) and cystathionine beta-synthase (CBS) had long been speculated to generate H2S, and inhibitors of these enzymes had been employed to characterize influences of H2S in various organs. Hydrogen Sulfide 119-122 cystathionine beta-synthase Mus musculus 48-75 22314625-2 2012 The enzymes cystathionine gamma-lyase (CSE) and cystathionine beta-synthase (CBS) had long been speculated to generate H2S, and inhibitors of these enzymes had been employed to characterize influences of H2S in various organs. Hydrogen Sulfide 204-207 cystathionine beta-synthase Mus musculus 48-75 22158625-10 2012 Renal cortical content of cystathionine beta-synthase and cystathionine gamma-lyase, hydrogen sulfide-generating enzymes, was significantly reduced in mice with type 1 diabetes or type 2 diabetes, coinciding with renal hypertrophy and matrix accumulation. Hydrogen Sulfide 85-101 cystathionine beta-synthase Mus musculus 26-53 22232681-3 2012 In this cascade, hypoxia elicits cerebral vasodilation via the coordinate actions of H(2)S formed by cystathionine beta-synthase (CBS) and CO generated by heme oxygenase (HO)-2. Hydrogen Sulfide 85-90 cystathionine beta-synthase Mus musculus 130-133 22047765-2 2011 Western blotting and immunocytochemistry were used to determine expression levels of the H2S-producing enzymes cystathionine-beta-synthase (CBS) and cystathionine-gamma-lyase (CSE) in gastric tissues and cultured smooth muscle cells. Hydrogen Sulfide 89-92 cystathionine beta-synthase Mus musculus 111-138 23071662-8 2012 The sensitizing effects of L-cysteine in wild-type mice were inhibited by a cystathionine beta-synthase inhibitor, D,L-propargylglycine (PAG), which inhibits H(2)S formation. Hydrogen Sulfide 158-163 cystathionine beta-synthase Mus musculus 76-103 22396778-1 2012 Hydrogen sulfide (H(2)S), a novel gaseous messenger, is synthesized endogenously from L-cysteine by two pyridoxal-5"-phosphate-dependent enzymes, cystathionine beta-synthase (CBS) and cystathionine gamma-lyase (CSE). Hydrogen Sulfide 0-16 cystathionine beta-synthase Mus musculus 146-173 22396778-1 2012 Hydrogen sulfide (H(2)S), a novel gaseous messenger, is synthesized endogenously from L-cysteine by two pyridoxal-5"-phosphate-dependent enzymes, cystathionine beta-synthase (CBS) and cystathionine gamma-lyase (CSE). Hydrogen Sulfide 18-23 cystathionine beta-synthase Mus musculus 146-173 23080150-4 2012 The purpose of this article is to review recent studies addressing the role of H2S in carotid body.Cystathionine gamma-lyase (CSE) and cystathionine beta synthase (CBS) are the two major enzymes that catalyze the formation of endogenous H2S. Hydrogen Sulfide 79-82 cystathionine beta-synthase Mus musculus 135-162 23080150-4 2012 The purpose of this article is to review recent studies addressing the role of H2S in carotid body.Cystathionine gamma-lyase (CSE) and cystathionine beta synthase (CBS) are the two major enzymes that catalyze the formation of endogenous H2S. Hydrogen Sulfide 237-240 cystathionine beta-synthase Mus musculus 135-162 21857260-13 2011 The simultaneous reduction in cystathionine-beta synthase and cystathionine-gamma lyase expression supports the role of H2S-generating enzymes as an adaptive response during stress states. Hydrogen Sulfide 120-123 cystathionine beta-synthase Mus musculus 30-57 20067586-3 2010 Cystathionine beta-synthase (EC 4.2.1.22), and cystathionine gamma-lyase (CSE; EC 4.4.1.1), also known as cystathionine, can generate H(2)S from cyst(e)ine. Hydrogen Sulfide 134-139 cystathionine beta-synthase Mus musculus 0-27 20955694-0 2011 Pharmacological activation and genetic manipulation of cystathionine beta-synthase alter circulating levels of homocysteine and hydrogen sulfide in mice. Hydrogen Sulfide 128-144 cystathionine beta-synthase Mus musculus 55-82 20955694-4 2011 Cystathionine beta-synthase (CBS) has been shown to catalyze H(2)S production in vitro. Hydrogen Sulfide 61-66 cystathionine beta-synthase Mus musculus 0-27 20955694-4 2011 Cystathionine beta-synthase (CBS) has been shown to catalyze H(2)S production in vitro. Hydrogen Sulfide 61-66 cystathionine beta-synthase Mus musculus 29-32 20955694-6 2011 This mode of regulation suggests the possibility for designing a small molecule activator of CBS to enhance H(2)S production. Hydrogen Sulfide 108-113 cystathionine beta-synthase Mus musculus 93-96 20955694-8 2011 We show here that CBS contributes significantly to endogenous H(2)S production in mice: adenovirus mediated over expression of CBS in the liver significantly increased circulating levels of H(2)S, whereas CBS deficiency resulted in reduced levels. Hydrogen Sulfide 62-67 cystathionine beta-synthase Mus musculus 18-21 20955694-8 2011 We show here that CBS contributes significantly to endogenous H(2)S production in mice: adenovirus mediated over expression of CBS in the liver significantly increased circulating levels of H(2)S, whereas CBS deficiency resulted in reduced levels. Hydrogen Sulfide 62-67 cystathionine beta-synthase Mus musculus 127-130 20955694-8 2011 We show here that CBS contributes significantly to endogenous H(2)S production in mice: adenovirus mediated over expression of CBS in the liver significantly increased circulating levels of H(2)S, whereas CBS deficiency resulted in reduced levels. Hydrogen Sulfide 190-195 cystathionine beta-synthase Mus musculus 18-21 20955694-8 2011 We show here that CBS contributes significantly to endogenous H(2)S production in mice: adenovirus mediated over expression of CBS in the liver significantly increased circulating levels of H(2)S, whereas CBS deficiency resulted in reduced levels. Hydrogen Sulfide 190-195 cystathionine beta-synthase Mus musculus 127-130 20955694-10 2011 Importantly, we show that circulating H(2)S levels are increased by pharmacological activation of CBS in vivo; i.e. in the presence of the endogenous activator. Hydrogen Sulfide 38-43 cystathionine beta-synthase Mus musculus 98-101 20955694-11 2011 Together, our data demonstrate that CBS activity partially regulates endogenous H(2)S in mice, and suggest that pharmacological activation of CBS is a promising approach for enhancing endogenous production of H(2)S for the treatment of cardiovascular and other diseases. Hydrogen Sulfide 80-85 cystathionine beta-synthase Mus musculus 36-39 20955694-11 2011 Together, our data demonstrate that CBS activity partially regulates endogenous H(2)S in mice, and suggest that pharmacological activation of CBS is a promising approach for enhancing endogenous production of H(2)S for the treatment of cardiovascular and other diseases. Hydrogen Sulfide 80-85 cystathionine beta-synthase Mus musculus 142-145 20955694-11 2011 Together, our data demonstrate that CBS activity partially regulates endogenous H(2)S in mice, and suggest that pharmacological activation of CBS is a promising approach for enhancing endogenous production of H(2)S for the treatment of cardiovascular and other diseases. Hydrogen Sulfide 209-214 cystathionine beta-synthase Mus musculus 36-39 20955694-11 2011 Together, our data demonstrate that CBS activity partially regulates endogenous H(2)S in mice, and suggest that pharmacological activation of CBS is a promising approach for enhancing endogenous production of H(2)S for the treatment of cardiovascular and other diseases. Hydrogen Sulfide 209-214 cystathionine beta-synthase Mus musculus 142-145 20943958-0 2011 Cystathionine beta-synthase and cystathionine gamma-lyase double gene transfer ameliorate homocysteine-mediated mesangial inflammation through hydrogen sulfide generation. Hydrogen Sulfide 143-159 cystathionine beta-synthase Mus musculus 0-27 21254839-1 2011 The enzymes of the transsulfuration pathway, cystathionine beta-synthase (CBS) and cystathionine gamma-lyase (CSE), are important for the endogenous production of hydrogen sulfide (H(2)S), a gaseous signaling molecule. Hydrogen Sulfide 163-179 cystathionine beta-synthase Mus musculus 45-72 21254839-1 2011 The enzymes of the transsulfuration pathway, cystathionine beta-synthase (CBS) and cystathionine gamma-lyase (CSE), are important for the endogenous production of hydrogen sulfide (H(2)S), a gaseous signaling molecule. Hydrogen Sulfide 163-179 cystathionine beta-synthase Mus musculus 74-77 21254839-1 2011 The enzymes of the transsulfuration pathway, cystathionine beta-synthase (CBS) and cystathionine gamma-lyase (CSE), are important for the endogenous production of hydrogen sulfide (H(2)S), a gaseous signaling molecule. Hydrogen Sulfide 181-186 cystathionine beta-synthase Mus musculus 45-72 21254839-1 2011 The enzymes of the transsulfuration pathway, cystathionine beta-synthase (CBS) and cystathionine gamma-lyase (CSE), are important for the endogenous production of hydrogen sulfide (H(2)S), a gaseous signaling molecule. Hydrogen Sulfide 181-186 cystathionine beta-synthase Mus musculus 74-77 21254839-3 2011 In this study, we report quantification of CBS and CSE in murine liver and kidney and their contribution to H(2)S generation in these tissues and in brain at saturating substrate concentrations. Hydrogen Sulfide 108-113 cystathionine beta-synthase Mus musculus 43-46 21254839-6 2011 At high substrate concentrations (20 mM each cysteine and homocysteine), the capacity for liver H(2)S production is approximately equal for CBS and CSE, whereas in kidney and brain, CBS constitutes the major source of H(2)S, accounting for ~80% and ~95%, respectively, of the total output. Hydrogen Sulfide 96-101 cystathionine beta-synthase Mus musculus 140-143 21254839-6 2011 At high substrate concentrations (20 mM each cysteine and homocysteine), the capacity for liver H(2)S production is approximately equal for CBS and CSE, whereas in kidney and brain, CBS constitutes the major source of H(2)S, accounting for ~80% and ~95%, respectively, of the total output. Hydrogen Sulfide 218-223 cystathionine beta-synthase Mus musculus 182-185 21254839-7 2011 At physiologically relevant concentrations of substrate, and adjusting for the differences in CBS versus CSE levels, we estimate that CBS accounts for only 3% of H(2)S production by the transsulfuration pathway enzymes in liver. Hydrogen Sulfide 162-167 cystathionine beta-synthase Mus musculus 134-137 19085910-5 2009 Livers of heterozygous CBS knockout mice neither down-regulated H(2)S nor exhibited the choleresis while overproducing CO. Hydrogen Sulfide 64-69 cystathionine beta-synthase Mus musculus 23-26 18855522-2 2009 Currently, pyridoxal-5"-phosphate (PLP)-dependent cystathionine beta-synthase (CBS) is thought to be the major H(2)S-producing enzyme in the brain. Hydrogen Sulfide 111-116 cystathionine beta-synthase Mus musculus 50-77 19085910-7 2009 CONCLUSION: Results collected from metabolome analyses suggested that CBS serves as a CO-sensitive modulator of H(2)S to support biliary excretion, shedding light on a putative role of the enzyme for stress-elicited adaptive response against bile-dependent detoxification processes. Hydrogen Sulfide 112-117 cystathionine beta-synthase Mus musculus 70-73 12358731-1 2002 Hydrogen sulfide (H2S) is endogenously produced in the brain from L-cysteine by the enzyme cystathionine beta-synthase (CBS) and functions as a neuromodulator in the brain. Hydrogen Sulfide 0-16 cystathionine beta-synthase Mus musculus 91-118 17488480-1 2007 Hydrogen sulphide (H(2)S) is synthesized from L-cysteine via the action of cystathionine-gamma-lyase (CSE) and cystathionine-beta-synthase (CBS). Hydrogen Sulfide 0-17 cystathionine beta-synthase Mus musculus 111-138 17488480-1 2007 Hydrogen sulphide (H(2)S) is synthesized from L-cysteine via the action of cystathionine-gamma-lyase (CSE) and cystathionine-beta-synthase (CBS). Hydrogen Sulfide 19-24 cystathionine beta-synthase Mus musculus 111-138 17853447-1 2007 Hydrogen sulfide (H(2)S) is a gaseous neuromodulator that can be synthesized by the transsulfuration enzymes cystathionine beta-synthase (CBS) and cystathionine gamma-lyase (CGL). Hydrogen Sulfide 0-16 cystathionine beta-synthase Mus musculus 109-136 17853447-1 2007 Hydrogen sulfide (H(2)S) is a gaseous neuromodulator that can be synthesized by the transsulfuration enzymes cystathionine beta-synthase (CBS) and cystathionine gamma-lyase (CGL). Hydrogen Sulfide 0-16 cystathionine beta-synthase Mus musculus 138-141 17853447-1 2007 Hydrogen sulfide (H(2)S) is a gaseous neuromodulator that can be synthesized by the transsulfuration enzymes cystathionine beta-synthase (CBS) and cystathionine gamma-lyase (CGL). Hydrogen Sulfide 18-23 cystathionine beta-synthase Mus musculus 109-136 17853447-1 2007 Hydrogen sulfide (H(2)S) is a gaseous neuromodulator that can be synthesized by the transsulfuration enzymes cystathionine beta-synthase (CBS) and cystathionine gamma-lyase (CGL). Hydrogen Sulfide 18-23 cystathionine beta-synthase Mus musculus 138-141 17853447-11 2007 In conclusion, both CBS and CGL are present in the amphibian retina, which suggests either a potential role for H(2)S as a gaseous neuromodulator in both neurons and glia in the retina or a requirement for cysteine and glutathione synthesis via the transsulfuration pathway as a defense against oxidative stress. Hydrogen Sulfide 112-117 cystathionine beta-synthase Mus musculus 20-23 16644696-3 2006 Cystathionine beta-synthase and cystathionine gamma-lyase, both of which can produce H(2)S, were expressed in mouse pancreatic islet cells and the beta-cell line, MIN6. Hydrogen Sulfide 85-90 cystathionine beta-synthase Mus musculus 0-27 12358731-1 2002 Hydrogen sulfide (H2S) is endogenously produced in the brain from L-cysteine by the enzyme cystathionine beta-synthase (CBS) and functions as a neuromodulator in the brain. Hydrogen Sulfide 18-21 cystathionine beta-synthase Mus musculus 91-118 11978815-3 2002 Here we use cystathionine beta-synthase (CBS) knock-out mice to clearly show that CBS produces endogenous H2S in the brain and that H2S production is greatly enhanced by the excitatory neurotransmitter l-glutamate, as well as by electrical stimulation. Hydrogen Sulfide 106-109 cystathionine beta-synthase Mus musculus 12-39 11978815-3 2002 Here we use cystathionine beta-synthase (CBS) knock-out mice to clearly show that CBS produces endogenous H2S in the brain and that H2S production is greatly enhanced by the excitatory neurotransmitter l-glutamate, as well as by electrical stimulation. Hydrogen Sulfide 106-109 cystathionine beta-synthase Mus musculus 41-44 11978815-3 2002 Here we use cystathionine beta-synthase (CBS) knock-out mice to clearly show that CBS produces endogenous H2S in the brain and that H2S production is greatly enhanced by the excitatory neurotransmitter l-glutamate, as well as by electrical stimulation. Hydrogen Sulfide 106-109 cystathionine beta-synthase Mus musculus 82-85 11978815-3 2002 Here we use cystathionine beta-synthase (CBS) knock-out mice to clearly show that CBS produces endogenous H2S in the brain and that H2S production is greatly enhanced by the excitatory neurotransmitter l-glutamate, as well as by electrical stimulation. Hydrogen Sulfide 132-135 cystathionine beta-synthase Mus musculus 12-39 11978815-3 2002 Here we use cystathionine beta-synthase (CBS) knock-out mice to clearly show that CBS produces endogenous H2S in the brain and that H2S production is greatly enhanced by the excitatory neurotransmitter l-glutamate, as well as by electrical stimulation. Hydrogen Sulfide 132-135 cystathionine beta-synthase Mus musculus 41-44 11978815-6 2002 These observations suggest that H2S is produced by CBS in response to neuronal excitation and that it may regulate some aspects of synaptic activity. Hydrogen Sulfide 32-35 cystathionine beta-synthase Mus musculus 51-54