PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
11169027-1	2001	BACKGROUND: In vitro stimulation of mononuclear cells (peripheral blood mononuclear cells; PBMCs) with an endotoxin (lipopolysaccharide; LPS) revealed elevated cell-associated levels of interleukin-1beta (IL-1beta) in end-stage renal disease (ESRD) patients on Cuprophan hemodialysis (HD), suggesting a defect in the process of IL-1beta"s release from activated cells.	cuprammonium cellulose	261-270	interleukin 1 beta	Homo sapiens	186-203	
12803505-6	2003	RESULTS: IL-1beta levels increased from 16.6 +/- 2.2 to 64.8 +/- 25.1 pg/mL on CU and 21.5 +/- 3.7 to 103.5 +/- 30.7 pg/mL on PS membrane over the 4-h dialysis session.	cuprammonium cellulose	79-81	interleukin 1 beta	Homo sapiens	9-17	
12381952-6	2002	In 2 of 10 experiments pro-IL-1beta was detected in monocytes interacting with Cu, PS and AN69S membrane.	cuprammonium cellulose	79-81	interleukin 1 beta	Homo sapiens	27-35	
11169027-9	2001	RESULTS: The total production (cell-associated plus extracellular) of LPS-induced IL-1beta (proIL-1beta plus mIL-1beta) was similar in healthy controls (25.96 +/- 0.84 ng/2.5 x 10(6) PBMC), PD patients (29.53 +/- 1.31 ng/2.5 x 106 PBMC), and in Cuprophan-treated HD patients (23.28 +/- 1.24 ng/2.5 x 10(6) PBMC).	cuprammonium cellulose	245-254	interleukin 1 beta	Homo sapiens	82-90	
7783414-4	1995	In contrast, LPS-induced IL-1 beta secretion (secreted amounts in % of total production) was similar to controls in uremic patients, but significantly reduced in ESRD patients on Cuprophan (P < 0.01).	cuprammonium cellulose	179-188	interleukin 1 beta	Homo sapiens	25-34	
8589297-9	1995	The release of IL-1 beta and TNF-alpha after 6 h by recirculating lymphomonocytes paralleled the NO synthase activity profile in endothelial cells and was significantly higher after cuprophan exposure than after polymethylmethacrylate (P < 0.0001).	cuprammonium cellulose	182-191	interleukin 1 beta	Homo sapiens	15-24	
7783414-9	1995	We conclude that LPS-induced IL-1 beta secretion, but not total production, is impaired in PBMC from ESRD patients on long-term Cuprophan hemodialysis.	cuprammonium cellulose	128-137	interleukin 1 beta	Homo sapiens	29-38	
1775252-5	1991	The alternate use of Cuprophan and Hemophan demonstrated that the production of TNF and IL1 was dependent on the type of haemodialysis membrane.	cuprammonium cellulose	21-30	interleukin 1 beta	Homo sapiens	88-91	
1819211-2	1991	Interleukin-1-beta (IL-1-beta) was measured in the plasma and peripheral blood mononuclear cell lysates of uremic patients undergoing maintenance hemodialysis by means of either cuprophane or polysulfone membranes.	cuprammonium cellulose	178-188	interleukin 1 beta	Homo sapiens	0-18	
1819211-5	1991	The study of the kinetics of IL-1-beta concentration during a single hemodialysis session revealed that the concentration of IL-1-beta fell to 21 and 22% of the predialysis level with cuprophane and polysulfone, respectively.	cuprammonium cellulose	184-194	interleukin 1 beta	Homo sapiens	29-38	
1819211-5	1991	The study of the kinetics of IL-1-beta concentration during a single hemodialysis session revealed that the concentration of IL-1-beta fell to 21 and 22% of the predialysis level with cuprophane and polysulfone, respectively.	cuprammonium cellulose	184-194	interleukin 1 beta	Homo sapiens	125-134	
1775252-6	1991	We also found that Cuprophan induced a reversible decrease of spontaneous and LPS-stimulated production of TNF, IL1 and IL6 during the haemodialysis session.	cuprammonium cellulose	19-28	interleukin 1 beta	Homo sapiens	112-115	
8352255-0	1993	Comparison of first use and reuse of cuprophan membranes on interleukin-1 receptor antagonist and interleukin-1 beta production by blood mononuclear cells.	cuprammonium cellulose	37-46	interleukin 1 beta	Homo sapiens	98-116	
2017267-8	1991	The IL-1 beta levels rose with CU from 87 +/-18 (ng/l) to 155 +/- 33 at 60 min and to 172 +/- 47 at 240 min.	cuprammonium cellulose	31-33	interleukin 1 beta	Homo sapiens	4-13