PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 11288046-0 2001 Effects of bezafibrate on insulin sensitivity and insulin secretion in non-obese Japanese type 2 diabetic patients. Bezafibrate 11-22 insulin Homo sapiens 26-33 11288046-1 2001 The aim of the present study was to investigate the effect of bezafibrate on insulin sensitivity and insulin secretion in 30 non-obese Japanese type 2 diabetic patients with hypertriglyceridemia (serum triglycerides > 150 mg/dL). Bezafibrate 62-73 insulin Homo sapiens 77-84 10403804-6 1999 Since UCP-3 mRNA levels are reduced in skeletal muscle of diabetic patients, this effect may be involved in the improvement of insulin sensitivity caused by bezafibrate in NIDDM. Bezafibrate 157-168 insulin Homo sapiens 127-134 10868845-0 2000 Effect of bezafibrate on insulin sensitivity in nonobese Japanese type 2 diabetic patients. Bezafibrate 10-21 insulin Homo sapiens 25-32 1458771-0 1992 Effects of bezafibrate on insulin sensitivity and glucose tolerance in subjects with combined hyperlipidemia. Bezafibrate 11-22 insulin Homo sapiens 26-33 9381994-0 1997 Comparison of bezafibrate versus lovastatin for lowering plasma insulin, fibrinogen, and plasminogen activator inhibitor-1 concentrations in hyperlipemic heart transplant patients. Bezafibrate 14-25 insulin Homo sapiens 64-71 7851275-4 1994 Administration of bezafibrate at 400 mg/day for 4 weeks to the IGT patients with hypertriglyceridemia resulted in an improvement of the plasma glucose level and insulin response to 75 g oral glucose loading associated with a concomitant decrease in non-esterified fatty acids. Bezafibrate 18-29 insulin Homo sapiens 161-168 7851275-5 1994 The ratio of the level of serum C-peptide to that of insulin after a 75 g oral glucose tolerance test (OGTT) was augmented after 4 weeks of bezafibrate administration. Bezafibrate 140-151 insulin Homo sapiens 53-60 33525941-4 2021 Three of them (tazarotenic acid, bezafibrate, and efaproxiral) affect insulin secretion in pancreatic INS-1 832/13 beta-cells with EC50 in the nanomolar concentration (5.73, 14.2, and 13.5 nM, respectively). Bezafibrate 33-44 insulin Homo sapiens 70-77 2653325-0 1989 Effects of bezafibrate on insulin secretion and peripheral insulin sensitivity in hyperlipidemic patients with and without diabetes. Bezafibrate 11-22 insulin Homo sapiens 26-33 23150952-16 2012 The principal differences between bezafibrate and other fibrates are related to effects on glucose level and insulin resistance. Bezafibrate 34-45 insulin Homo sapiens 109-116 23254592-8 2013 In conclusion, bezafibrate improved lipid metabolism and insulin sensitivity but did not affect office, home or ambulatory BP in hypertensive patients with dyslipidemia. Bezafibrate 15-26 insulin Homo sapiens 57-64 25360162-15 2014 Therefore, bezafibrate could be used to treat insulin resistance in patients with type 2 diabetes mellitus and dyslipidemia. Bezafibrate 11-22 insulin Homo sapiens 46-53 12733699-9 2003 In conclusion, an improvement of hyperlipidemia by bezafibrate may be attributed to reduction of blood pressure and amelioration of insulin sensitivity. Bezafibrate 51-62 insulin Homo sapiens 132-139 19131462-8 2009 Post hoc analysis of the effect of bezafibrate on progression of preexisting diabetes also showed a lower hazard for progression to use of antidiabetic medication (0.54 [0.38-0.76]) or progression to use of insulin (0.78 [0.55-1.10]). Bezafibrate 35-46 insulin Homo sapiens 207-214 12733699-1 2003 We examined cellular membrane fatty acid composition and insulin sensitivity in patients with mild essential hypertension and hyperlipidemia, and investigated whether bezafibrate, a lipid-lowering drug, could improve elevated blood pressure and insulin sensitivity in these subjects by ameliorating cellular membrane fatty acid composition. Bezafibrate 167-178 insulin Homo sapiens 245-252 16606809-0 2006 Attenuation of progression of insulin resistance in patients with coronary artery disease by bezafibrate. Bezafibrate 93-104 insulin Homo sapiens 30-37 12754275-11 2003 Bezafibrate-induced diminished insulin resistance is associated with a reduction of CET and PLTP activity. Bezafibrate 0-11 insulin Homo sapiens 31-38 12472919-0 2002 Bezafibrate-induced improvement in glucose uptake and endothelial function in protease inhibitor-associated insulin resistance. Bezafibrate 0-11 insulin Homo sapiens 108-115 12472919-7 2002 This effect could result from the increased glucose uptake observed and a decrease in insulin resistance secondary to the lowered triglyceride levels by bezafibrate. Bezafibrate 153-164 insulin Homo sapiens 86-93 11893366-0 2002 Severe hypertriglyceridemia with insulin resistance is associated with systemic inflammation: reversal with bezafibrate therapy in a randomized controlled trial. Bezafibrate 108-119 insulin Homo sapiens 33-40