PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 28057172-3 2016 The effects of five azole antifungal agents, fluconazole, itraconazole, ketoconazole, miconazole, and voriconazole, on the aminopyrine N-demethylation activity by CYP2C8 were investigated. Miconazole 86-96 cytochrome P450 family 2 subfamily C member 8 Homo sapiens 163-169 28057172-8 2016 However, ketoconazole and miconazole noncompetitively inhibited CYP2C8-mediated aminopyrine N-demethylation with the inhibitory constant values of 1.98 and 0.86 microM, respectively. Miconazole 26-36 cytochrome P450 family 2 subfamily C member 8 Homo sapiens 64-70 28057172-9 2016 CONCLUSION: These results suggest that ketoconazole and miconazole might inhibit CYP2C8 clinically. Miconazole 56-66 cytochrome P450 family 2 subfamily C member 8 Homo sapiens 81-87