PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
22262564-0	2012	Antifungal miconazole induces cardiotoxicity via inhibition of APE/Ref-1-related pathway in rat neonatal cardiomyocytes.	Miconazole	11-21	apurinic/apyrimidinic endodeoxyribonuclease 1	Rattus norvegicus	63-66	
22262564-0	2012	Antifungal miconazole induces cardiotoxicity via inhibition of APE/Ref-1-related pathway in rat neonatal cardiomyocytes.	Miconazole	11-21	apurinic/apyrimidinic endodeoxyribonuclease 1	Rattus norvegicus	67-72	
22262564-6	2012	Among genes overlapped in all these categories, apurinic/apyrimidinic endonuclease-1/redox factor-1 (APE/Ref-1), a redox-related gene, was prominent and was diminished in the miconazole-treated group.	Miconazole	175-185	apurinic/apyrimidinic endodeoxyribonuclease 1	Rattus norvegicus	101-104	
22262564-6	2012	Among genes overlapped in all these categories, apurinic/apyrimidinic endonuclease-1/redox factor-1 (APE/Ref-1), a redox-related gene, was prominent and was diminished in the miconazole-treated group.	Miconazole	175-185	apurinic/apyrimidinic endodeoxyribonuclease 1	Rattus norvegicus	105-110	
22262564-7	2012	Changes in the O(2)(-) production and apoptosis induction in response to miconazole were inhibited in cardiomyocytes transfected with adenoviral APE/Ref-1.	Miconazole	73-83	apurinic/apyrimidinic endodeoxyribonuclease 1	Rattus norvegicus	145-148	
22262564-7	2012	Changes in the O(2)(-) production and apoptosis induction in response to miconazole were inhibited in cardiomyocytes transfected with adenoviral APE/Ref-1.	Miconazole	73-83	apurinic/apyrimidinic endodeoxyribonuclease 1	Rattus norvegicus	149-154	
22262564-8	2012	Overexpression of APE/Ref-1 reversed the reduction in beating frequency induced by miconazole.	Miconazole	83-93	apurinic/apyrimidinic endodeoxyribonuclease 1	Rattus norvegicus	18-21	
22262564-8	2012	Overexpression of APE/Ref-1 reversed the reduction in beating frequency induced by miconazole.	Miconazole	83-93	apurinic/apyrimidinic endodeoxyribonuclease 1	Rattus norvegicus	22-27	
22262564-9	2012	Our results demonstrate that miconazole may induce rat cardiotoxicity via a ROS-mediated pathway, which is initiated by the inhibition of APE/Ref-1 expression.	Miconazole	29-39	apurinic/apyrimidinic endodeoxyribonuclease 1	Rattus norvegicus	138-141	
22262564-9	2012	Our results demonstrate that miconazole may induce rat cardiotoxicity via a ROS-mediated pathway, which is initiated by the inhibition of APE/Ref-1 expression.	Miconazole	29-39	apurinic/apyrimidinic endodeoxyribonuclease 1	Rattus norvegicus	142-147	
26634046-10	2015	Rhamnetin (1 and 3 microM) treatment downregulated cleaved caspase 3 and upregulated APE/Ref-1 expression in miconazole-stimulated cells.	Miconazole	109-119	apurinic/apyrimidinic endodeoxyribonuclease 1	Rattus norvegicus	85-88	
26634046-10	2015	Rhamnetin (1 and 3 microM) treatment downregulated cleaved caspase 3 and upregulated APE/Ref-1 expression in miconazole-stimulated cells.	Miconazole	109-119	apurinic/apyrimidinic endodeoxyribonuclease 1	Rattus norvegicus	89-94