PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
17656468-8	2007	The observed stimulation of DNA adduct formation by ellipticine was attributed to induction of CYP1A1 and/or 1A2-mediated increase in ellipticine oxidative activation to 13-hydroxy- and 12-hydroxyellipticine, the metabolites generating two major DNA adducts in human and rat livers.	ellipticine	52-63	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	95-101	
22167207-10	2011	Based on these studies, we attribute most of the enhancing effects of VPA and TSA on ellipticine cytotoxicity to enhanced ellipticine-DNA adduct formation caused by an increase in levels of cytochrome b5, CYP3A4 and CYP1A1 in neuroblastoma cells.	ellipticine	85-96	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	216-222	
22167207-10	2011	Based on these studies, we attribute most of the enhancing effects of VPA and TSA on ellipticine cytotoxicity to enhanced ellipticine-DNA adduct formation caused by an increase in levels of cytochrome b5, CYP3A4 and CYP1A1 in neuroblastoma cells.	ellipticine	122-133	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	216-222	
20027146-9	2009	This effect might be associated with formation of two covalent ellipticine-derived DNA adducts, identical to those formed by 13-hydroxy- and 12-hydroxyellipticine, the ellipticine metabolites generated by CYP1A1, 1B1 and 3A4, lactoperoxidase and cyclooxygenase 1, the enzymes expressed in U87MG cells.	ellipticine	63-74	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	205-216	
17656468-8	2007	The observed stimulation of DNA adduct formation by ellipticine was attributed to induction of CYP1A1 and/or 1A2-mediated increase in ellipticine oxidative activation to 13-hydroxy- and 12-hydroxyellipticine, the metabolites generating two major DNA adducts in human and rat livers.	ellipticine	134-145	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	95-101	
17159771-8	2006	Using the reconstituted enzymatic system, we demonstrated that the detoxication ellipticine metabolites, 7-hydroxyellipticine and 9-hydroxyellipticine, are mainly generated by CYP1A1 and 1A2, while those responsible for DNA binding, 13-hydroxy-, 12-hydroxyellipticine and ellipticine N(2)-oxide, by CYP3A1 and 2C3.	ellipticine	80-91	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	176-190	
16507648-4	2006	The formation of OH-flutamide was markedly inhibited by ellipticine, an inhibitor of CYP1A1/1A2, and was mainly catalyzed by the recombinant CYP1A2.	ellipticine	56-67	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	85-91	
12123750-3	2002	We examined a panel of genetically engineered V79 cell lines including the parental line V79MZ and recombinant cells expressing the human CYP enzymes CYP1A1, CYP1A2 or CYP3A4 for their ability to activate ellipticine.	ellipticine	205-216	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	150-156	
15548707-7	2004	Using recombinant human enzymes, oxidation of ellipticine to 9-hydroxyellipticine and 7-hydroxyellipticine by CYP1A1/2 and to 13-hydroxyellipticine and N(2)-oxide by CYP3A4 was corroborated.	ellipticine	46-57	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	110-118	
11218050-15	2001	This pattern was also confirmed using the CYP 1A1 inhibitor ellipticine.	ellipticine	60-71	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	42-49	
11790342-6	2000	By contrast, low concentrations (0.025-0.050 microM) of the mammalian CYP1A1 inhibitor ellipticine completely abolished EROD activity, but had no effect (up to 1 mM) on caffeine metabolism or POD activity in either species.	ellipticine	87-98	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	70-76	
10490621-6	1999	This negative autoregulation is abolished by ellipticine (an inhibitor of CYP1A1) and by catalase (which catalyzes H(2)O(2) catabolism), thus implying that H(2)O(2) is an intermediate.	ellipticine	45-56	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	74-80	
8759031-6	1996	Cotreatment with alpha-naphthoflavone (alpha NF, 1 microM) or ellipticine (ELLIP, 0.1 nM) only partially inhibited the induction of AHH activity by BaP (30 microM).	ellipticine	62-73	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	132-135	
8759031-6	1996	Cotreatment with alpha-naphthoflavone (alpha NF, 1 microM) or ellipticine (ELLIP, 0.1 nM) only partially inhibited the induction of AHH activity by BaP (30 microM).	ellipticine	75-80	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	132-135	
29471073-7	2018	Our results indicate that the underlying mechanisms whereby etoposide and ellipticine regulate CYP1A1 expression must be different and may not be linked to p53 activation alone.	ellipticine	74-85	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	95-101	
8474022-4	1993	The prototypic CYP1A xenobiotic inhibitor and substrate probes alpha-naphthoflavone, ellipticine, 7-ethoxycoumarin and 7-ethoxyresorufin all inhibited CYP1A1- and CYP1A2-mediated phenacetin O-deethylation as well as the high-affinity component of human liver phenacetin O-deethylase activity.	ellipticine	85-96	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	151-157	
29471073-4	2018	We found that etoposide and ellipticine induced CYP1A1 in TP53(+/+) cells but not in TP53(-/-) cells, demonstrating that the mechanism of CYP1A1 induction is p53-dependent; cisplatin had no such effect.	ellipticine	28-39	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	48-54	
29471073-4	2018	We found that etoposide and ellipticine induced CYP1A1 in TP53(+/+) cells but not in TP53(-/-) cells, demonstrating that the mechanism of CYP1A1 induction is p53-dependent; cisplatin had no such effect.	ellipticine	28-39	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	138-144