PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
6253773-2	1980	It enhances the conversion of dihomogammalinolenic acid (DGLA) to PGE1 but it blocks the activity of the delta-6-desaturase, an enzyme necessary for replenishment of DGLA stores from dietary precursors.	8,11,14-Eicosatrienoic Acid	166-170	fatty acid desaturase 2	Homo sapiens	105-123	
34303883-8	2021	In MCF7 cells, letrozole caused a dose dependent increase in FADS2-catalyzed DGLA synthesis, which plateaued in SK-N-SH cells.	8,11,14-Eicosatrienoic Acid	77-81	fatty acid desaturase 2	Homo sapiens	61-66	
34303883-9	2021	CONCLUSION: Letrozole restores Delta6-desaturase mediated synthesis of the anti-inflammatory PGE1-precursor DGLA in vitro and is the first endocrine-active agent to have opposing effects on FADS1 and FADS2 catalyzed activities.	8,11,14-Eicosatrienoic Acid	108-112	fatty acid desaturase 2	Homo sapiens	37-48	
3642201-5	1986	Delta-6-desaturase is the enzyme responsible for converting linoleic acid to dihomogamma-linolenic acid.	8,11,14-Eicosatrienoic Acid	77-103	fatty acid desaturase 2	Homo sapiens	0-18	
3642201-7	1986	It is proposed that prophylaxis against the effects of delta-6-desaturase inhibition could be achieved by the adoption of an Eskimo-like diet containing the essential fatty acid metabolites gamma-linolenic acid and/or dihomogamma-linolenic acid and eicosapentaenoic acid per se in high concentrations.	8,11,14-Eicosatrienoic Acid	218-244	fatty acid desaturase 2	Homo sapiens	55-73	
6270521-6	1981	In meat eaters or omnivores which can acquire arachidonic acid from food, the main consequences of D6D loss will be deficiencies of GLA, dihomogamma-linolenic acid (DGLA) and prostaglandin (PG) E1.	8,11,14-Eicosatrienoic Acid	137-163	fatty acid desaturase 2	Homo sapiens	99-102	
6324395-5	1984	The striking difference between GLA and LA as regards growth suppression of human hepatoma cells in culture appears to imply a metabolic block in the hepatoma cells, involving the enzyme delta-6-desaturase, in the conversion of LA to GLA and thence via dihomo-gamma-linolenic acid to the prostaglandins of the 1 series.	8,11,14-Eicosatrienoic Acid	253-280	fatty acid desaturase 2	Homo sapiens	187-205	
18479586-6	2009	Although less pronounced, associations between FADS1 FADS2 haplotypes and PUFA in erythrocyte membranes, particularly arachidonic and dihomo-gamma-linolenic acid, could be established.	8,11,14-Eicosatrienoic Acid	134-161	fatty acid desaturase 2	Homo sapiens	53-58	
24854601-5	2014	In addition higher levels of the FADS2-derived n-6 PUFAs gamma-linolenic acid and dihomo-gamma-linolenic acid were observed in PBMCs of patients as well as lower levels of n-3 PUFAs.	8,11,14-Eicosatrienoic Acid	82-109	fatty acid desaturase 2	Homo sapiens	33-38	
22884424-5	2012	Most significantly, we found the levels of dihomo-gamma-linolenic acid (DGLA) to positively correlate with neuroticism and HAM-D scores and negatively correlate with GAF scores; and HAM-D to negatively correlate with linoleic acid (LA) and positively correlate with fatty acid desaturase 2 (FADS2) activity, an enzyme responsible for converting LA to gamma-linolenic acid (GLA).	8,11,14-Eicosatrienoic Acid	43-70	fatty acid desaturase 2	Homo sapiens	266-289	
22884424-5	2012	Most significantly, we found the levels of dihomo-gamma-linolenic acid (DGLA) to positively correlate with neuroticism and HAM-D scores and negatively correlate with GAF scores; and HAM-D to negatively correlate with linoleic acid (LA) and positively correlate with fatty acid desaturase 2 (FADS2) activity, an enzyme responsible for converting LA to gamma-linolenic acid (GLA).	8,11,14-Eicosatrienoic Acid	43-70	fatty acid desaturase 2	Homo sapiens	291-296	
22884424-5	2012	Most significantly, we found the levels of dihomo-gamma-linolenic acid (DGLA) to positively correlate with neuroticism and HAM-D scores and negatively correlate with GAF scores; and HAM-D to negatively correlate with linoleic acid (LA) and positively correlate with fatty acid desaturase 2 (FADS2) activity, an enzyme responsible for converting LA to gamma-linolenic acid (GLA).	8,11,14-Eicosatrienoic Acid	72-76	fatty acid desaturase 2	Homo sapiens	266-289	
22884424-5	2012	Most significantly, we found the levels of dihomo-gamma-linolenic acid (DGLA) to positively correlate with neuroticism and HAM-D scores and negatively correlate with GAF scores; and HAM-D to negatively correlate with linoleic acid (LA) and positively correlate with fatty acid desaturase 2 (FADS2) activity, an enzyme responsible for converting LA to gamma-linolenic acid (GLA).	8,11,14-Eicosatrienoic Acid	72-76	fatty acid desaturase 2	Homo sapiens	291-296	
33387849-8	2021	The D6D index was calculated as dihomo-gamma-linolenic acid (DGLA 20: 3 n-6) / linoleic acid (18: 2 n - 6), and the D5D index was calculated as arachidonic acid (20: 4 n - 6) / DGLA (20: 3 n - 6).	8,11,14-Eicosatrienoic Acid	32-59	fatty acid desaturase 2	Homo sapiens	4-7	
31797636-7	2020	Seven SNPs were significant in association with dihomo-gamma-linolenic acid, of which five were within fatty acid desaturases FADS1 and FADS2.	8,11,14-Eicosatrienoic Acid	48-75	fatty acid desaturase 2	Homo sapiens	136-141	
17892040-14	2007	The gamma-linolenic acid supplementation in diet allows to omitt the inefficient delta6-desaturase system which has an effect in rising of dihomo-gamma-linolenic acid (DGLA), arachidonic acid (AA) and their derivatives.	8,11,14-Eicosatrienoic Acid	139-166	fatty acid desaturase 2	Homo sapiens	81-98	
17892040-14	2007	The gamma-linolenic acid supplementation in diet allows to omitt the inefficient delta6-desaturase system which has an effect in rising of dihomo-gamma-linolenic acid (DGLA), arachidonic acid (AA) and their derivatives.	8,11,14-Eicosatrienoic Acid	168-172	fatty acid desaturase 2	Homo sapiens	81-98	
11597788-5	2001	A increased Delta(6)-desaturase activity is postulated as the cause for the increased level of desaturate products or the increased Delta6-activity index (Ratio of gamma-linoleic acid+dihomogamma-linolenic acid to linoleic acid) (1.21 vs. 0.27; P<0.001).	8,11,14-Eicosatrienoic Acid	184-210	fatty acid desaturase 2	Homo sapiens	12-31