PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 21344174-8 2012 Theanine also repressed phorbol 12-myristate 13-acetate and calcium ionophore A23187-induced TNF-alpha, IL-1beta, IL-6, and IL-8 secretion by suppressing NF-kappaB activation. Calcimycin 78-84 C-X-C motif chemokine ligand 8 Homo sapiens 124-128 30915077-5 2019 PMA-induced NETs were decorated with annexins, azurocidin and histone H3, whereas A23187-induced NETs were decorated with granule proteins including CAMP/LL37, CRISP3, lipocalin and MMP8, histones H1.0, H1.4, and H1.5, interleukin-8, protein-arginine deiminase-4 (PADI4), and alpha-enolase. Calcimycin 82-88 C-X-C motif chemokine ligand 8 Homo sapiens 219-232 22687252-8 2012 In addition, KOB03 inhibited the production of inflammatory cytokines such as TNF-alpha, IL-1beta, IL-6 and IL-8 in PMA/A23187-stimulated HMC-1 mast cells by suppressing their gene expression and blocking the ERK1/2 and p38 MAPK and NF-kappaB pathways. Calcimycin 120-126 C-X-C motif chemokine ligand 8 Homo sapiens 108-112 24049649-6 2012 Furthermore, calcium ionophore (A23187), which upregulates DUOX and NOX2 activities, strongly induced oxidative stress and IL-8 and IL-6 overexpression in IB3-1 cells. Calcimycin 32-38 C-X-C motif chemokine ligand 8 Homo sapiens 123-127 21142820-5 2011 Apigenin significantly inhibits the inductive effect of phorbol 12-myristate 13-acetate (PMA) plus A23187 on the production of inflammatory cytokines such as tumor necrosis factor (TNF)-alpha, interleukin (IL)-8, IL-6, and granulocyte-macrophage colony-stimulating factor (GM-CSF). Calcimycin 99-105 C-X-C motif chemokine ligand 8 Homo sapiens 193-211 20164300-5 2010 Our results showed that butrin, isobutrin, and butein significantly reduced the phorbol 12-myristate 13-acetate and calcium ionophore A23187-induced inflammatory gene expression and production of TNF-alpha, IL-6, and IL-8 in HMC-1 cells by inhibiting the activation of NF-kappaB. Calcimycin 134-140 C-X-C motif chemokine ligand 8 Homo sapiens 217-221 19483309-6 2009 PMA plus A23187 significantly increased IL-1beta, IL-6, IL-8, and TNF-alpha production compared with media control (p<0.05). Calcimycin 9-15 C-X-C motif chemokine ligand 8 Homo sapiens 56-60 19514995-6 2009 MW (1 mg/ml) inhibited PMA plus A23187-stimulated gene expression and production of TNF-alpha, IL-6, and IL-8. Calcimycin 32-38 C-X-C motif chemokine ligand 8 Homo sapiens 105-109 19416633-6 2009 Resveratrol significantly inhibited the PMA plus A23187-induction of inflammatory cytokines such as tumour necrosis factor (TNF)-alpha, interleukin (IL)-6 and IL-8. Calcimycin 49-55 C-X-C motif chemokine ligand 8 Homo sapiens 159-163 17113069-4 2007 Scopoletin significantly and dose-dependently inhibits the way in which phorbol 12-myristate 13-acetate (PMA) plus A23187 induces the production of inflammatory cytokines such as tumor necrosis factor (TNF)-alpha, interleukin (IL)-6, and IL-8 (P<0.05). Calcimycin 115-121 C-X-C motif chemokine ligand 8 Homo sapiens 238-242 18222974-9 2008 In addition, MEVA attenuated the phorbol 12-myristate 13-acetate and calcium ionophore A23187 (PMACI)-stimulated secretion of tumor necrosis factor-alpha, interleukin-6 (IL-6), and IL-8 in human mast cells. Calcimycin 87-93 C-X-C motif chemokine ligand 8 Homo sapiens 181-185 18071264-6 2007 LR inhibited the PMA plus A23187-induced increase in IL-6, IL-8, and TNF-alpha expression in HMC-1 cells. Calcimycin 26-32 C-X-C motif chemokine ligand 8 Homo sapiens 59-63 17609508-4 2007 In addition, PVAE attenuated phorbol 12-myristate 13-acetate (PMA) and calcium ionophore A23187-stimulated TNF-alpha, IL-6, and IL-8 secretion in human mast cells. Calcimycin 89-95 C-X-C motif chemokine ligand 8 Homo sapiens 128-132 15893895-8 2005 CA also inhibited interleukin-8 and tumor necrosis factor-alpha secretion from the phorbol 12-myristate 13-acetate and A23187-induced HMC-1 cells (human mast cell line). Calcimycin 119-125 C-X-C motif chemokine ligand 8 Homo sapiens 18-63 17079162-4 2007 Fisetin decreased phorbol-12-myristate 13-acetate plus calcium ionophore A23187 (PMACI)-stimulated gene expression and production of tumor necrosis factor-alpha (TNF-alpha), interleukin (IL)-1beta, IL-4, IL-6, and IL-8 in HMC-1 cells. Calcimycin 73-79 C-X-C motif chemokine ligand 8 Homo sapiens 214-218 16890260-8 2006 Furthermore, AEMD attenuated the phorbol 12-myristate 13-acetate (PMA) and calcium ionophore A23187-stimulated TNF-alpha, IL-8 and IL-6 secretion in human mast cells. Calcimycin 93-99 C-X-C motif chemokine ligand 8 Homo sapiens 122-126 16955241-1 2006 OBJECTIVE: To investigate whether FK506 (tacrolimus) can inhibit Fas- or A23187-induced interleukin (IL)-8 expression and cell death in A549 human alveolar epithelial cells, plus Fas-mediated acute lung injury in vivo. Calcimycin 73-79 C-X-C motif chemokine ligand 8 Homo sapiens 88-106 17135765-5 2007 RESULTS: EGCG (100 microM) inhibited PMA+A23187-induced TNF-alpha, IL-6 and IL-8 expression and production. Calcimycin 41-47 C-X-C motif chemokine ligand 8 Homo sapiens 76-80 15924880-5 2005 Sabaeksan (1 mg/ml) inhibited PMA plus A23187-induced TNF-alpha, IL-6, and IL-8 secretion by 43.86+/-5.26%, 56.39+/-3.65%, and 63.48+/-2.54%, respectively. Calcimycin 39-45 C-X-C motif chemokine ligand 8 Homo sapiens 75-79 15664665-5 2005 Similar to BK, the calcium ionophore A23187 also upregulated the stimulatory effect of IL-1beta and TNFalpha on IL-8 production. Calcimycin 37-43 C-X-C motif chemokine ligand 8 Homo sapiens 112-116 11589728-4 2001 Enriched isolated skin mast cells released both TNF-alpha and IL-8 following activation with either anti-IgE, SCF, substance P, compound 48/80 or A23187. Calcimycin 146-152 C-X-C motif chemokine ligand 8 Homo sapiens 62-66 15286717-3 2004 Combined treatment with Ca(2+)-ionophore and phorbol-myristate-acetate (A23187/PMA) increased IL-8 mRNA and protein levels. Calcimycin 72-78 C-X-C motif chemokine ligand 8 Homo sapiens 94-98 15331599-6 2004 We also studied the results of cPLA2 activation by epidermal growth factor (EGF) and calcium ionophore (A23187) on IL-8 and COX-2 reporter gene activity, mRNA level, and protein synthesis. Calcimycin 104-110 C-X-C motif chemokine ligand 8 Homo sapiens 115-119 15331599-9 2004 Methyl arachidonyl fluorophosphate, a cPLA2 inhibitor, inhibited the effect of A23187 and of EGF on both IL-8 and COX-2 reporter gene activity, steady state levels of IL-8 and COX-2 mRNA, and IL-8 and COX-2 protein expression. Calcimycin 79-85 C-X-C motif chemokine ligand 8 Homo sapiens 105-109 15331599-9 2004 Methyl arachidonyl fluorophosphate, a cPLA2 inhibitor, inhibited the effect of A23187 and of EGF on both IL-8 and COX-2 reporter gene activity, steady state levels of IL-8 and COX-2 mRNA, and IL-8 and COX-2 protein expression. Calcimycin 79-85 C-X-C motif chemokine ligand 8 Homo sapiens 167-171 15331599-9 2004 Methyl arachidonyl fluorophosphate, a cPLA2 inhibitor, inhibited the effect of A23187 and of EGF on both IL-8 and COX-2 reporter gene activity, steady state levels of IL-8 and COX-2 mRNA, and IL-8 and COX-2 protein expression. Calcimycin 79-85 C-X-C motif chemokine ligand 8 Homo sapiens 167-171 15331599-10 2004 Small inhibitory RNAs directed against PPAR-gamma1 and -gamma2 blunted the effect of A23187 and of EGF on IL-8 and COX-2 protein expression. Calcimycin 85-91 C-X-C motif chemokine ligand 8 Homo sapiens 106-110 15331599-11 2004 Moreover small inhibitory RNAs directed against cPLA2 decreased the effect of A23187 and EGF on IL-8 and COX-2 protein expression. Calcimycin 78-84 C-X-C motif chemokine ligand 8 Homo sapiens 96-100 15518173-4 2004 We provided evidence that the secretion of TNF-alpha and IL-8 from HMC-1 cells was induced by Ca2+-ionophore A23187 or Ca2+-ATPase inhibitor TSG. Calcimycin 109-115 C-X-C motif chemokine ligand 8 Homo sapiens 57-61 15518173-6 2004 IL-8 secretion in response to A23187 or TSG was inhibited by 49.2% for A23187 and 34.1% for TSG, respectively, compared to absence of WSC. Calcimycin 30-36 C-X-C motif chemokine ligand 8 Homo sapiens 0-4 15518173-6 2004 IL-8 secretion in response to A23187 or TSG was inhibited by 49.2% for A23187 and 34.1% for TSG, respectively, compared to absence of WSC. Calcimycin 71-77 C-X-C motif chemokine ligand 8 Homo sapiens 0-4 12133975-5 2002 PMA plus A23187 or IgE plus anti-IgE induced the production of IL-8 and GM-CSF in supernatants of HMC-1 cells and IL-4 and IL-6 in supernatants of KU812 cells. Calcimycin 9-15 C-X-C motif chemokine ligand 8 Homo sapiens 63-67 11392610-7 2001 RESULTS: A23187 and thapsigargin caused a dose- and time-dependent accumulation of IL-8 mRNA and protein production which was dependent on the release of Ca2+ from intracellular stores. Calcimycin 9-15 C-X-C motif chemokine ligand 8 Homo sapiens 83-87 11392610-8 2001 FK506, a specific inhibitor of calcineurin, inhibited A23187- and thapsigargin-induced IL-8 mRNA expression in a dose dependent manner. Calcimycin 54-60 C-X-C motif chemokine ligand 8 Homo sapiens 87-91 11392610-9 2001 Reporter gene studies and actinomycin D chase experiments showed that A23187 and thapsigargin enhanced IL-8 gene transcription and stabilized IL-8 mRNA transcripts, respectively. Calcimycin 70-76 C-X-C motif chemokine ligand 8 Homo sapiens 103-107 11392610-9 2001 Reporter gene studies and actinomycin D chase experiments showed that A23187 and thapsigargin enhanced IL-8 gene transcription and stabilized IL-8 mRNA transcripts, respectively. Calcimycin 70-76 C-X-C motif chemokine ligand 8 Homo sapiens 142-146 9725250-12 1998 Furthermore, exogenous PGE2 and calcium ionophore A23187 also stimulated IL-8 release. Calcimycin 50-56 C-X-C motif chemokine ligand 8 Homo sapiens 73-77 9802987-5 1998 IL-8 was retained in these storage organelles for several days after the removal of the stimulus and could be released by EC secretagogues such as phorbol myristate acetate, the calcium ionophore A23187, and histamine. Calcimycin 196-202 C-X-C motif chemokine ligand 8 Homo sapiens 0-4 8915773-8 1996 The calcium ionophore A23187 reproduced the effect of NaF, and this effect was antagonized by EGTA, suggesting that PLD activation was, at least in part, a calcium-regulated event. Calcimycin 22-28 C-X-C motif chemokine ligand 8 Homo sapiens 54-57 9237814-9 1997 The calcium ionophore A23187 was a weak, PKC dependent, stimulant of IL-8 production. Calcimycin 22-28 C-X-C motif chemokine ligand 8 Homo sapiens 69-73 7759889-0 1995 Increased cell-associated IL-8 in human exudative and A23187-treated peripheral blood neutrophils. Calcimycin 54-60 C-X-C motif chemokine ligand 8 Homo sapiens 26-30 7759889-5 1995 Furthermore, cell-associated IL-8 in peripheral blood neutrophils increased 20-fold during incubation at 37 degrees C in vitro and was increased over 200-fold after treatment with the Ca2+ ionophore A23187. Calcimycin 199-205 C-X-C motif chemokine ligand 8 Homo sapiens 29-33 7759889-6 1995 More than 35% of the cell-associated IL-8 could be released by stimulation with either Ca2+ ionophore A23187 or phorbol myristate acetate. Calcimycin 102-108 C-X-C motif chemokine ligand 8 Homo sapiens 37-41 7514637-8 1994 FMLP, PAF, and a stable PAF agonist did not stimulate significant IL-8 production, however, a calcium ionophore (A23187) did induce IL-8 release and this was suppressed by UK 74505. Calcimycin 113-119 C-X-C motif chemokine ligand 8 Homo sapiens 132-136 2173722-5 1990 Release of NAP-1 was stimulus specific because A23187 evoked the release of LTB4 but not NAP-1, whereas LPS and zymosan induced the release of both LTB4 and NAP-1. Calcimycin 47-53 C-X-C motif chemokine ligand 8 Homo sapiens 11-16 8319811-0 1993 Calcium ionophore A23187 induces interleukin-8 gene expression and protein secretion in human monocytic cells. Calcimycin 18-24 C-X-C motif chemokine ligand 8 Homo sapiens 33-46 8319811-4 1993 Incubation of the cells with the calcium ionophore A23187 resulted in consistent increased IL-8 gene expression comparable to that of cells treated with endotoxin alone. Calcimycin 51-57 C-X-C motif chemokine ligand 8 Homo sapiens 91-95 1315244-8 1992 In contrast, 3 h NaF (10 mM) pretreatment enhanced responsiveness of the gonadotrope to the Ca2+ ionophore A23187 in a protein kinase C- and cAMP-dependent manner. Calcimycin 107-113 C-X-C motif chemokine ligand 8 Homo sapiens 17-20 2173722-1 1990 The capacity of lipopolysaccharide (LPS), zymosan, and calcium ionophore A23187 to induce neutrophil chemotactic activity (NCA), leukotriene B4 (LTB4), and neutrophil attractant/activation protein (NAP-1) release from human alveolar macrophages (AM) retrieved from normal nonsmokers was evaluated. Calcimycin 73-79 C-X-C motif chemokine ligand 8 Homo sapiens 198-203 1332845-2 1992 Pretreatment of pituitary cell cultures with NaF (a guanyl nucleotide binding protein activator, 10 mM, 3 h) also decreased subsequent GnRH-stimulated LH release, and in addition, provoked a decrease in GnRH receptor number, an increase in GnRH receptor affinity, reduction of GnRH-stimulated IP production to basal levels, and an increase in the amount of LH released in response to stimulation with the calcium ionophore A23187. Calcimycin 423-429 C-X-C motif chemokine ligand 8 Homo sapiens 45-48 1332845-8 1992 A23187-provoked LH release was enhanced immediately after NaF pretreatment (30 microM A23187-stimulated LH release in NaF-pretreated cells was 170% of control levels). Calcimycin 0-6 C-X-C motif chemokine ligand 8 Homo sapiens 58-61 1332845-8 1992 A23187-provoked LH release was enhanced immediately after NaF pretreatment (30 microM A23187-stimulated LH release in NaF-pretreated cells was 170% of control levels). Calcimycin 0-6 C-X-C motif chemokine ligand 8 Homo sapiens 118-121 1332845-8 1992 A23187-provoked LH release was enhanced immediately after NaF pretreatment (30 microM A23187-stimulated LH release in NaF-pretreated cells was 170% of control levels). Calcimycin 86-92 C-X-C motif chemokine ligand 8 Homo sapiens 58-61 1332845-8 1992 A23187-provoked LH release was enhanced immediately after NaF pretreatment (30 microM A23187-stimulated LH release in NaF-pretreated cells was 170% of control levels). Calcimycin 86-92 C-X-C motif chemokine ligand 8 Homo sapiens 118-121 1692318-2 1990 High concentrations of NaF furthermore reduce thrombin- or A23187-stimulated prostacyclin production. Calcimycin 59-65 C-X-C motif chemokine ligand 8 Homo sapiens 23-26