PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 17438683-12 2006 TPA and A23187 can markedly rectify the disturbance of IL-2/IL-10 secretion ratio by increasing the IL-2 secretion after scald. Calcimycin 8-14 interleukin 2 Mus musculus 55-59 32397768-5 2020 In the present study, we showed that quercetin suppressed the A23187-mediated expression of interleukin (IL) -2 in T cells.Methods: Mouse splenocytes, enriched T cells, and EL4 cells, a mouse T cell line, were treated with quercetin, and then stimulated with A23187, a calcium ionophore, concanavalin A, or anti-CD3epsilon and anti-CD28 antibodies. Calcimycin 62-68 interleukin 2 Mus musculus 92-111 17438683-12 2006 TPA and A23187 can markedly rectify the disturbance of IL-2/IL-10 secretion ratio by increasing the IL-2 secretion after scald. Calcimycin 8-14 interleukin 2 Mus musculus 100-104 2139366-9 1990 However, in the presence of calcium ionophore (A23187) and PMA, both J11d+ and J11d- subpopulations proliferated by producing and responding to endogenous IL-2 but not IL-4. Calcimycin 47-53 interleukin 2 Mus musculus 155-159 7673697-10 1995 A23187 (100 nM) and phorbol 12,13 dibutyrate (10 nM), but not 4 alpha-phorbol (10 nM), were able to restore IL-2-dependent CTLL-2 proliferation in the presence of ADA. Calcimycin 0-6 interleukin 2 Mus musculus 108-112 7622352-3 1995 On the other hand, 3 micrograms/ml of SSd greatly up-regulated the growth response and interleukin 2 (IL-2)/interleukin 4 (IL-4) production induced through a receptor-bypassed pathway by calcium ionophore A23187 plus phorbol 12-myristate 13-acetate (PMA) in thymocytes, whereas it only slightly up-regulated them in spleen cells. Calcimycin 205-211 interleukin 2 Mus musculus 87-100 7622352-3 1995 On the other hand, 3 micrograms/ml of SSd greatly up-regulated the growth response and interleukin 2 (IL-2)/interleukin 4 (IL-4) production induced through a receptor-bypassed pathway by calcium ionophore A23187 plus phorbol 12-myristate 13-acetate (PMA) in thymocytes, whereas it only slightly up-regulated them in spleen cells. Calcimycin 205-211 interleukin 2 Mus musculus 102-106 1558852-9 1992 Using monoclonal antibodies to neutralize IL-2 and block IL-2 receptors we showed that 1,25(OH)2D3 enhanced the IL-2-independent component of the A23187- and TPA-induced mitogenesis. Calcimycin 146-152 interleukin 2 Mus musculus 42-46 1558852-9 1992 Using monoclonal antibodies to neutralize IL-2 and block IL-2 receptors we showed that 1,25(OH)2D3 enhanced the IL-2-independent component of the A23187- and TPA-induced mitogenesis. Calcimycin 146-152 interleukin 2 Mus musculus 57-61 1558852-9 1992 Using monoclonal antibodies to neutralize IL-2 and block IL-2 receptors we showed that 1,25(OH)2D3 enhanced the IL-2-independent component of the A23187- and TPA-induced mitogenesis. Calcimycin 146-152 interleukin 2 Mus musculus 57-61 1972723-6 1990 When Ca2+ influx was induced by calcium ionophore A23187 or ionomycin, the clone produced IL-2 in response to anti-CD3 in the presence of anti-CD4. Calcimycin 50-56 interleukin 2 Mus musculus 90-94 3118559-4 1987 Incubating feline PBL with a cocktail of the calcium ionophore A23187 and phorbol ester also led to the generation of cytotoxic cells as well as the production of high levels of IL-2. Calcimycin 63-69 interleukin 2 Mus musculus 178-182 2311647-4 1990 IL2 was most successfully induced with a high dose of the calcium ionophore A23187 combined with phorbol 12-myristate 13-acetate (PMA). Calcimycin 76-82 interleukin 2 Mus musculus 0-3 3117882-1 1987 A B cell lymphoma A20.2J and splenic B cells produced an active material to support the proliferation of an interleukin 2 (IL-2)-dependent T cell line, CTLL-2, by stimulation with both calcium ionophore A23187 and phorbol myristate acetate (PMA). Calcimycin 203-209 interleukin 2 Mus musculus 108-121 3117882-1 1987 A B cell lymphoma A20.2J and splenic B cells produced an active material to support the proliferation of an interleukin 2 (IL-2)-dependent T cell line, CTLL-2, by stimulation with both calcium ionophore A23187 and phorbol myristate acetate (PMA). Calcimycin 203-209 interleukin 2 Mus musculus 123-127 2956328-4 1987 However, HTL which had been pretreated with IL 2 and were unresponsive to antigen responded strongly to antigen + A23187 or to A23187 + PMA but failed to respond to antigen + PMA. Calcimycin 114-120 interleukin 2 Mus musculus 44-48 2956328-4 1987 However, HTL which had been pretreated with IL 2 and were unresponsive to antigen responded strongly to antigen + A23187 or to A23187 + PMA but failed to respond to antigen + PMA. Calcimycin 127-133 interleukin 2 Mus musculus 44-48 2952285-17 1987 In contrast, activation by PMA plus A23187 coordinately induces expression of nonspecific cytolytic activity, secretion of lymphokines (IL-3 and IL-2), and cell proliferation. Calcimycin 36-42 interleukin 2 Mus musculus 145-149 3104323-10 1987 On the contrary, signals for DNA synthesis generated by binding of IL2 to IL2 receptors are different from those for IL2 production and IL2 receptor expression, as the combination of TPA and A23187 could not induce DNA synthesis without IL2. Calcimycin 191-197 interleukin 2 Mus musculus 74-77 3104323-3 1987 A combination of a phorbol ester, 12-O-tetradecanoylphorbol-13-acetate (TPA), and a calcium ionophore, A23187, induced the expression of IL2 receptors on resting 6-1 cells and induced DNA synthesis in the presence of IL2. Calcimycin 103-109 interleukin 2 Mus musculus 137-140 3104323-3 1987 A combination of a phorbol ester, 12-O-tetradecanoylphorbol-13-acetate (TPA), and a calcium ionophore, A23187, induced the expression of IL2 receptors on resting 6-1 cells and induced DNA synthesis in the presence of IL2. Calcimycin 103-109 interleukin 2 Mus musculus 217-220 3104323-6 1987 IL2 receptors induced by A23187 alone were mostly low affinity receptors, whereas the combination of TPA and A23187 induced high affinity receptors in addition to low affinity receptors. Calcimycin 25-31 interleukin 2 Mus musculus 0-3 3104323-7 1987 Resting KO.6 cells produced IL2 in response to a combination of TPA and A23187, whereas either one of the agents did not induce the production of IL2. Calcimycin 72-78 interleukin 2 Mus musculus 28-31 3104323-10 1987 On the contrary, signals for DNA synthesis generated by binding of IL2 to IL2 receptors are different from those for IL2 production and IL2 receptor expression, as the combination of TPA and A23187 could not induce DNA synthesis without IL2. Calcimycin 191-197 interleukin 2 Mus musculus 67-70 3104323-10 1987 On the contrary, signals for DNA synthesis generated by binding of IL2 to IL2 receptors are different from those for IL2 production and IL2 receptor expression, as the combination of TPA and A23187 could not induce DNA synthesis without IL2. Calcimycin 191-197 interleukin 2 Mus musculus 74-77 3104323-10 1987 On the contrary, signals for DNA synthesis generated by binding of IL2 to IL2 receptors are different from those for IL2 production and IL2 receptor expression, as the combination of TPA and A23187 could not induce DNA synthesis without IL2. Calcimycin 191-197 interleukin 2 Mus musculus 74-77 3104323-10 1987 On the contrary, signals for DNA synthesis generated by binding of IL2 to IL2 receptors are different from those for IL2 production and IL2 receptor expression, as the combination of TPA and A23187 could not induce DNA synthesis without IL2. Calcimycin 191-197 interleukin 2 Mus musculus 74-77 3108164-0 1987 Interleukin-2 responses of MRL/lpr mouse splenocytes and lymph node cells induced by TPA and A23187. Calcimycin 93-99 interleukin 2 Mus musculus 0-13 3108164-3 1987 The combination of TPA and A23187 in the lpr cells induced both proliferation and production of IL-2 in a Ca++-dependent fashion. Calcimycin 27-33 interleukin 2 Mus musculus 96-100 3096619-4 1986 A marked synergism between A23187 and PMA was noted in induction of T cell enlargement, IL-2 release, and induction of IL-2 responsiveness. Calcimycin 27-33 interleukin 2 Mus musculus 88-92 2944961-6 1986 The proliferation of HTL in response to PMA + A23187 could be completely inhibited either by cyclosporine A (CsA) or by PC61.5, a monoclonal antibody directed against the murine IL 2 receptor; however, the proliferation of CTL in response to PMA alone was not affected either by CsA or by PC61.5. Calcimycin 46-52 interleukin 2 Mus musculus 178-182 3096619-4 1986 A marked synergism between A23187 and PMA was noted in induction of T cell enlargement, IL-2 release, and induction of IL-2 responsiveness. Calcimycin 27-33 interleukin 2 Mus musculus 119-123 3096619-7 1986 Addition of A23187/PMA to the IL-2-dependent CTL-L clone did not result in cell proliferation. Calcimycin 12-18 interleukin 2 Mus musculus 30-34 3096619-10 1986 The results indicate that T cell mitogenesis by A23187/PMA is IL-2-dependent, and suggest a critical role for protein kinase C in IL-2 release and induction of IL-2 responsiveness. Calcimycin 48-54 interleukin 2 Mus musculus 62-66 3096619-11 1986 In addition, the data suggest distinct, but co-operative pathways of IL-2 receptor induction, controlled by elevated Ca2+ alone and by protein kinase C. Subsequent intracellular events of T cell activation by A23187/PMA may be quite similar to those triggered by Con A, since both kinds of stimulation are blocked by agents such as cyclosporin A, dbcAMP and K+ channel blockers. Calcimycin 209-215 interleukin 2 Mus musculus 69-73 3079793-12 1986 We suggest that the activating signals provided by A23187 and PMA are at least part of the sequence of events that lead to production of IL 2 in either IL 1-dependent or IL 1-independent T cell lines. Calcimycin 51-57 interleukin 2 Mus musculus 137-141 3081905-3 1986 The remaining Lyt2-, L3T4- cells were stimulated for IL-2 production by using concanavalin A (Con A) or A23187, together with phorbol 12-myristate 13-acetate (PMA). Calcimycin 104-110 interleukin 2 Mus musculus 53-57 3081905-4 1986 We found that these "double-negative" thymocytes were unresponsive to Con A plus PMA but produced substantial amounts of IL-2 when stimulated with A23187 plus PMA. Calcimycin 147-153 interleukin 2 Mus musculus 121-125 6432347-5 1984 Release of IL-2 from IL-1/A23187-stimulated EL-4 was detected within 5 hr after initiation of the cultures, and both signals were required at the same time to initiate synthesis or release of IL-2. Calcimycin 26-32 interleukin 2 Mus musculus 11-15 2999231-4 1985 Both calcium ionophores, A23187 and ionomycin, in conjunction with 12-O-tetradecanoylphorbol 13-acetate (TPA) mimicked the effect of antigen or interleukin 2 (IL 2) by inducing strong proliferative and alloantigen-specific cytotoxic responses. Calcimycin 25-31 interleukin 2 Mus musculus 144-157 2999231-4 1985 Both calcium ionophores, A23187 and ionomycin, in conjunction with 12-O-tetradecanoylphorbol 13-acetate (TPA) mimicked the effect of antigen or interleukin 2 (IL 2) by inducing strong proliferative and alloantigen-specific cytotoxic responses. Calcimycin 25-31 interleukin 2 Mus musculus 159-163