PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
18180332-8	2008	Treatment of endothelial cells with a calcium ionophore, A23187, decreased alpha-actinin-4-eNOS interaction, leading to translocation of alpha-actinin-4 from plasma membrane to cytoplasm.	Calcimycin	57-63	nitric oxide synthase 3	Bos taurus	91-95	
17210830-8	2007	The Ca2+ ionophore A23187 stimulated eNOS phosphorylation, as well as cGMP production, and pretreatment with intracellular or extracellular Ca2+ chelators inhibited thrombin-induced eNOS phosphorylation and cGMP production.	Calcimycin	19-25	nitric oxide synthase 3	Bos taurus	37-41	
17210830-8	2007	The Ca2+ ionophore A23187 stimulated eNOS phosphorylation, as well as cGMP production, and pretreatment with intracellular or extracellular Ca2+ chelators inhibited thrombin-induced eNOS phosphorylation and cGMP production.	Calcimycin	19-25	nitric oxide synthase 3	Bos taurus	182-186	
15784500-6	2005	When ovine eNOS was transiently expressed in COS-7 cells (COS-7/oeNOS), A23187 increased specific catalytic activity in a dose- and time-dependent manner.	Calcimycin	72-78	nitric oxide synthase 3	Bos taurus	11-15	
11796200-6	2002	Treatment of intact cells with the calcium ionophore A23187 reduced the L-arginine concentration of half-maximal eNOS activity, which is consistent with a measured increase in L-arginine uptake.	Calcimycin	53-59	nitric oxide synthase 3	Bos taurus	113-117