PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 12437499-3 2002 Excess cholesterol is stored as cholesteryl ester through an esterification process regulated in part by acyl coenzyme A:cholesterol acyltransferase (ACAT). Cholesterol Esters 32-49 carboxylesterase 1 Homo sapiens 105-148 15533865-1 2004 BACKGROUND: Inhibition of the acyl coenzyme A:cholesterol acyltransferase (ACAT) enzyme may prevent excess accumulation of cholesteryl esters in macrophages. Cholesterol Esters 123-141 carboxylesterase 1 Homo sapiens 30-73 15533865-1 2004 BACKGROUND: Inhibition of the acyl coenzyme A:cholesterol acyltransferase (ACAT) enzyme may prevent excess accumulation of cholesteryl esters in macrophages. Cholesterol Esters 123-141 carboxylesterase 1 Homo sapiens 75-79 15538545-1 2004 Acyl coenzyme A:cholesterol acyltransferase (ACAT) is the enzyme that catalyzes the conversion of intracellular cholesterol into cholesteryl esters. Cholesterol Esters 129-147 carboxylesterase 1 Homo sapiens 0-43 15314256-6 2004 In genetically mutant cell lines that overproduce cholesterol but cannot synthesize cholesteryl esters (CEs) because of deficient ACAT activity, Abeta production is almost completely inhibited. Cholesterol Esters 104-107 carboxylesterase 1 Homo sapiens 130-134 15063831-0 2004 Inhibitory effects of Polygonum cuspidatum water extract (PCWE) and its component resveratrol [correction of rasveratrol] on acyl-coenzyme A-cholesterol acyltransferase activity for cholesteryl ester synthesis in HepG2 cells. Cholesterol Esters 182-199 carboxylesterase 1 Homo sapiens 125-168 15063831-5 2004 Among the main active chemicals of P. cuspidatum, resveratrol, a kind of flavonoid, decreased ACAT activity in a dose-dependent manner from the level of 10(-3) M. Theses results strongly suggest that PCWE reduces the cholesteryl ester formation in human hepatocytes by inhibiting ACAT. Cholesterol Esters 217-234 carboxylesterase 1 Homo sapiens 94-98 12360153-2 2002 Inhibition of the acyl coenzyme A: cholesterol acyltransferase (ACAT) enzyme in the arterial wall may prevent excess accumulation of cholesteryl esters in macrophages. Cholesterol Esters 133-151 carboxylesterase 1 Homo sapiens 18-62 12360153-2 2002 Inhibition of the acyl coenzyme A: cholesterol acyltransferase (ACAT) enzyme in the arterial wall may prevent excess accumulation of cholesteryl esters in macrophages. Cholesterol Esters 133-151 carboxylesterase 1 Homo sapiens 64-68 12437499-3 2002 Excess cholesterol is stored as cholesteryl ester through an esterification process regulated in part by acyl coenzyme A:cholesterol acyltransferase (ACAT). Cholesterol Esters 32-49 carboxylesterase 1 Homo sapiens 150-154 11772425-4 2002 ACAT is present in a variety of tissues and is responsible for catalyzing the conversion of free cholesterol to the more readily stored cholesteryl esters. Cholesterol Esters 136-154 carboxylesterase 1 Homo sapiens 0-4 12168771-7 2001 The results indicate that 17beta-estradiol induces an increase in the amount of labeled cholesterol released from the cells and, the data obtained from the measurements of ACAT and CEH activities showed that, in estrogen-treated HMDM, the cholesteryl ester cycle favors the hydrolysis of lipoprotein cholesterol by CEH in comparison with its acylation by ACAT. Cholesterol Esters 239-256 carboxylesterase 1 Homo sapiens 172-176 12168771-7 2001 The results indicate that 17beta-estradiol induces an increase in the amount of labeled cholesterol released from the cells and, the data obtained from the measurements of ACAT and CEH activities showed that, in estrogen-treated HMDM, the cholesteryl ester cycle favors the hydrolysis of lipoprotein cholesterol by CEH in comparison with its acylation by ACAT. Cholesterol Esters 239-256 carboxylesterase 1 Homo sapiens 181-184 12168771-7 2001 The results indicate that 17beta-estradiol induces an increase in the amount of labeled cholesterol released from the cells and, the data obtained from the measurements of ACAT and CEH activities showed that, in estrogen-treated HMDM, the cholesteryl ester cycle favors the hydrolysis of lipoprotein cholesterol by CEH in comparison with its acylation by ACAT. Cholesterol Esters 239-256 carboxylesterase 1 Homo sapiens 315-318 12168771-7 2001 The results indicate that 17beta-estradiol induces an increase in the amount of labeled cholesterol released from the cells and, the data obtained from the measurements of ACAT and CEH activities showed that, in estrogen-treated HMDM, the cholesteryl ester cycle favors the hydrolysis of lipoprotein cholesterol by CEH in comparison with its acylation by ACAT. Cholesterol Esters 239-256 carboxylesterase 1 Homo sapiens 355-359 11584272-4 2001 Acyl-coenzyme A:cholesterol acyltransferase (ACAT), the enzyme that catalyses the formation of cholesteryl esters, modulates the generation of Abeta through the tight control of the equilibrium between free cholesterol and cholesteryl esters. Cholesterol Esters 95-113 carboxylesterase 1 Homo sapiens 0-43 11584272-4 2001 Acyl-coenzyme A:cholesterol acyltransferase (ACAT), the enzyme that catalyses the formation of cholesteryl esters, modulates the generation of Abeta through the tight control of the equilibrium between free cholesterol and cholesteryl esters. Cholesterol Esters 95-113 carboxylesterase 1 Homo sapiens 45-49 11584272-4 2001 Acyl-coenzyme A:cholesterol acyltransferase (ACAT), the enzyme that catalyses the formation of cholesteryl esters, modulates the generation of Abeta through the tight control of the equilibrium between free cholesterol and cholesteryl esters. Cholesterol Esters 223-241 carboxylesterase 1 Homo sapiens 0-43 11584272-4 2001 Acyl-coenzyme A:cholesterol acyltransferase (ACAT), the enzyme that catalyses the formation of cholesteryl esters, modulates the generation of Abeta through the tight control of the equilibrium between free cholesterol and cholesteryl esters. Cholesterol Esters 223-241 carboxylesterase 1 Homo sapiens 45-49 11409902-1 2001 Cholesteryl ester hydrolase (CEH) is responsible for hydrolysis of stored cholesterol esters in macrophage foam cells and release of free cholesterol for high-density lipoprotein-mediated efflux. Cholesterol Esters 74-92 carboxylesterase 1 Homo sapiens 0-27 11409902-1 2001 Cholesteryl ester hydrolase (CEH) is responsible for hydrolysis of stored cholesterol esters in macrophage foam cells and release of free cholesterol for high-density lipoprotein-mediated efflux. Cholesterol Esters 74-92 carboxylesterase 1 Homo sapiens 29-32 11015575-10 2000 These data identify the human macrophage CEH, demonstrate its expression in human peripheral blood macrophage and human macrophage cell line, THP-1, and suggest its role in the intracellular cholesteryl ester metabolism. Cholesterol Esters 191-208 carboxylesterase 1 Homo sapiens 41-44 11294643-1 2001 Fatty acyl CoA and cholesterol are the substrates for cholesteryl ester synthesis by acyl coenzyme A:cholesterol acyltransferase (ACAT). Cholesterol Esters 54-71 carboxylesterase 1 Homo sapiens 85-128 11353332-1 2001 Acyl-coenzyme A:cholesterol acyltransferase (ACAT) is an intracellular enzyme that produces cholesteryl esters in various tissues. Cholesterol Esters 92-110 carboxylesterase 1 Homo sapiens 0-43 11353332-1 2001 Acyl-coenzyme A:cholesterol acyltransferase (ACAT) is an intracellular enzyme that produces cholesteryl esters in various tissues. Cholesterol Esters 92-110 carboxylesterase 1 Homo sapiens 45-49 9409282-10 1997 However, inhibition of cholesteryl ester synthesis by 70% with an acyl coenzyme A:cholesterol acyltransferase inhibitor did not affect VLDL secretion. Cholesterol Esters 23-40 carboxylesterase 1 Homo sapiens 66-109 7493995-1 1995 Acyl-coenzyme A:cholesterol acyltransferase (ACAT) catalyzes the formation of intracellular cholesterol esters in various tissues. Cholesterol Esters 92-110 carboxylesterase 1 Homo sapiens 0-43 9185766-7 1997 The activities of acyl-coenzyme A:cholesterol acyltransferase (ACAT), which governs cholesteryl ester formation, in obese and nonobese patients were 12.5 +/- 1.7 and 8.1 +/- 1.2 pmol/min/mg protein, respectively (P < .05), and the low-density lipoprotein (LDL) receptor mRNA levels were 5.3 +/- 0.7 and 4.5 +/- 0.9 molecules of mRNA/microg of RNA, respectively. Cholesterol Esters 84-101 carboxylesterase 1 Homo sapiens 18-61 9185766-7 1997 The activities of acyl-coenzyme A:cholesterol acyltransferase (ACAT), which governs cholesteryl ester formation, in obese and nonobese patients were 12.5 +/- 1.7 and 8.1 +/- 1.2 pmol/min/mg protein, respectively (P < .05), and the low-density lipoprotein (LDL) receptor mRNA levels were 5.3 +/- 0.7 and 4.5 +/- 0.9 molecules of mRNA/microg of RNA, respectively. Cholesterol Esters 84-101 carboxylesterase 1 Homo sapiens 63-67 9140228-5 1997 Among the main active chemicals of OGT, baicalein, a kind of flavonoid, decreased ACAT activity in a dose-dependent fashion from the level of 10(-6)M. These results strongly suggest that OGT reduces the cholesteryl ester formation in human hepatocytes by inhibiting ACAT, and that baicalein may, in part, be responsible for ACAT inhibition. Cholesterol Esters 203-220 carboxylesterase 1 Homo sapiens 82-86 9140228-5 1997 Among the main active chemicals of OGT, baicalein, a kind of flavonoid, decreased ACAT activity in a dose-dependent fashion from the level of 10(-6)M. These results strongly suggest that OGT reduces the cholesteryl ester formation in human hepatocytes by inhibiting ACAT, and that baicalein may, in part, be responsible for ACAT inhibition. Cholesterol Esters 203-220 carboxylesterase 1 Homo sapiens 266-270 9140228-5 1997 Among the main active chemicals of OGT, baicalein, a kind of flavonoid, decreased ACAT activity in a dose-dependent fashion from the level of 10(-6)M. These results strongly suggest that OGT reduces the cholesteryl ester formation in human hepatocytes by inhibiting ACAT, and that baicalein may, in part, be responsible for ACAT inhibition. Cholesterol Esters 203-220 carboxylesterase 1 Homo sapiens 266-270 8645354-2 1996 The unregulated deposition of cholesteryl esters, as lipid droplets within the cytoplasm of these cells, is responsible for the formation of foam cells; this process is thought to be regulated by the balance between cholesterol esterification, by acyl CoA:cholesterol acyltransferase (ACAT), and hydrolysis, by neutral cholesteryl ester hydrolase (nCEH). Cholesterol Esters 30-48 carboxylesterase 1 Homo sapiens 247-283 8645354-2 1996 The unregulated deposition of cholesteryl esters, as lipid droplets within the cytoplasm of these cells, is responsible for the formation of foam cells; this process is thought to be regulated by the balance between cholesterol esterification, by acyl CoA:cholesterol acyltransferase (ACAT), and hydrolysis, by neutral cholesteryl ester hydrolase (nCEH). Cholesterol Esters 30-48 carboxylesterase 1 Homo sapiens 285-289 8645354-2 1996 The unregulated deposition of cholesteryl esters, as lipid droplets within the cytoplasm of these cells, is responsible for the formation of foam cells; this process is thought to be regulated by the balance between cholesterol esterification, by acyl CoA:cholesterol acyltransferase (ACAT), and hydrolysis, by neutral cholesteryl ester hydrolase (nCEH). Cholesterol Esters 30-48 carboxylesterase 1 Homo sapiens 319-346 7493995-1 1995 Acyl-coenzyme A:cholesterol acyltransferase (ACAT) catalyzes the formation of intracellular cholesterol esters in various tissues. Cholesterol Esters 92-110 carboxylesterase 1 Homo sapiens 45-49 8543556-3 1995 We also found that hepatic acyl coenzyme A cholesterol acyltransferase (ACAT) activity is very low in the animals, resulting in decreased cholesteryl ester contents in the liver. Cholesterol Esters 138-155 carboxylesterase 1 Homo sapiens 27-70 8543556-3 1995 We also found that hepatic acyl coenzyme A cholesterol acyltransferase (ACAT) activity is very low in the animals, resulting in decreased cholesteryl ester contents in the liver. Cholesterol Esters 138-155 carboxylesterase 1 Homo sapiens 72-76 7507110-8 1994 Furthermore, TNF-alpha-mediated stimulation of cholesteryl ester synthesis was compromised by incubation of cells with an inhibitor of ACAT. Cholesterol Esters 47-64 carboxylesterase 1 Homo sapiens 135-139 7822296-1 1995 Acyl-coenzyme A:cholesterol acyltransferase (ACAT) is an intracellular enzyme that catalyzes the conjugation of long chain fatty acid and cholesterol to form cholesteryl esters. Cholesterol Esters 158-176 carboxylesterase 1 Homo sapiens 0-43 7822296-1 1995 Acyl-coenzyme A:cholesterol acyltransferase (ACAT) is an intracellular enzyme that catalyzes the conjugation of long chain fatty acid and cholesterol to form cholesteryl esters. Cholesterol Esters 158-176 carboxylesterase 1 Homo sapiens 45-49 21244871-1 1994 Acyl coenzyme A-cholesterol acyltransferase (ACAT) catalyzes the formation of intracellular cholesterol esters. Cholesterol Esters 92-110 carboxylesterase 1 Homo sapiens 0-43 21244871-1 1994 Acyl coenzyme A-cholesterol acyltransferase (ACAT) catalyzes the formation of intracellular cholesterol esters. Cholesterol Esters 92-110 carboxylesterase 1 Homo sapiens 45-49 21244871-3 1994 Under pathologic conditions, accumulation of the ACAT reaction product as cytoplasmic cholesterol ester lipid droplets within macrophages and smooth muscle cells is a characteristic feature of early lesions of human atherosclerotic plaques. Cholesterol Esters 86-103 carboxylesterase 1 Homo sapiens 49-53 8197480-1 1994 Acyl coenzyme A:cholesterol acyltransferase (ACAT) is an intracellular enzyme that catalyzes the formation of cholesterol esters from cholesterol and long-chain fatty acyl-coenzyme A. Cholesterol Esters 110-128 carboxylesterase 1 Homo sapiens 0-43 8197480-1 1994 Acyl coenzyme A:cholesterol acyltransferase (ACAT) is an intracellular enzyme that catalyzes the formation of cholesterol esters from cholesterol and long-chain fatty acyl-coenzyme A. Cholesterol Esters 110-128 carboxylesterase 1 Homo sapiens 45-49 1418688-4 1992 PEG-modified CEH synthesized various cholesterol esters with significant substrate specificity. Cholesterol Esters 37-55 carboxylesterase 1 Homo sapiens 13-16 1418688-1 1992 The solvent dependency and substrate specificity of polyethylene glycol (PEG)-modified cholesterol esterase (CEH) catalyzing cholesterol ester synthesis in organic solvents were studied. Cholesterol Esters 87-104 carboxylesterase 1 Homo sapiens 109-112 8257725-9 1993 The cellular cholesteryl ester cycle (i.e., the neutral cholesteryl ester hydrolase) was unaffected by sphingosine (at 5 microM). Cholesterol Esters 13-30 carboxylesterase 1 Homo sapiens 56-83 8407899-2 1993 Intracellularly, an essential element in forming cholesterol ester from cholesterol is the enzyme acyl-coenzyme A:cholesterol acyltransferase (ACAT). Cholesterol Esters 49-66 carboxylesterase 1 Homo sapiens 98-141 8407899-2 1993 Intracellularly, an essential element in forming cholesterol ester from cholesterol is the enzyme acyl-coenzyme A:cholesterol acyltransferase (ACAT). Cholesterol Esters 49-66 carboxylesterase 1 Homo sapiens 143-147 3681141-7 1987 Cholesteryl ester storage in clear cell renal cancer may be a result of a primary abnormality in ACAT activity or it may be a result of reduced release of free cholesterol (relative to cell content) with a secondary elevation in ACAT activity. Cholesterol Esters 0-17 carboxylesterase 1 Homo sapiens 97-101 2079605-8 1990 The ACAT inhibitor caused a modest increase of 125I-labeled HDL3 binding to enterocytes and significantly decreased its degradation; both effects correlated with inhibition of cholesteryl ester synthesis. Cholesterol Esters 176-193 carboxylesterase 1 Homo sapiens 4-8 2007178-7 1991 These results suggest that a poor down-regulation of LDL receptors, which is attributable to increased acyl coenzyme A:cholesterol acyltransferase activity, and scavenger receptors are induced and that these metabolic changes in lipoprotein receptors and an increased acyl coenzyme A:cholesterol acyltransferase activity contribute to cholesterol ester accumulation in monocyte-macrophage-like cells. Cholesterol Esters 335-352 carboxylesterase 1 Homo sapiens 103-146 34153284-3 2021 It has been proposed that Ces1d/CES1 might also catalyze cholesteryl ester (CE) hydrolysis in the liver and be responsible for the hydrolysis of high-density lipoprotein (HDL)-derived CE, thus contributing to the final step in the reverse cholesterol transport (RCT) pathway, where cholesterol is secreted from the liver into bile and feces, either directly or after conversion to water-soluble bile salts. Cholesterol Esters 57-74 carboxylesterase 1 Homo sapiens 32-36 3681141-7 1987 Cholesteryl ester storage in clear cell renal cancer may be a result of a primary abnormality in ACAT activity or it may be a result of reduced release of free cholesterol (relative to cell content) with a secondary elevation in ACAT activity. Cholesterol Esters 0-17 carboxylesterase 1 Homo sapiens 229-233 31175950-1 2019 Human carboxylesterase 1 (CES1), primarily expressed in the liver and adipocytes, is responsible for the hydrolysis of endogenous esters (such as cholesteryl esters and triacylglycerols) and the metabolism of xenobiotic esters (such as clopidogrel and oseltamivir), thus participates in physiological and pathological processes. Cholesterol Esters 146-164 carboxylesterase 1 Homo sapiens 6-24 6712778-3 1984 Moreover, the reduced CEH activity in cells from the hypercholesterolemic patients was accompanied by significant accumulation of cholesteryl ester. Cholesterol Esters 130-147 carboxylesterase 1 Homo sapiens 22-25 6712778-7 1984 These data suggest that the intracellular accumulation of cholesteryl esters is determined in part by the extracellular concentrations of LDL-cholesterol and by the activity of CEH within the cells. Cholesterol Esters 58-76 carboxylesterase 1 Homo sapiens 177-180 6405661-4 1983 The ability of each CEH to hydrolyze individual cholesterol esters was tested. Cholesterol Esters 48-66 carboxylesterase 1 Homo sapiens 20-23 4006035-1 1985 A fluorescent cholesterylester analogue, cholesteryl 6-pyrenylhexanoate (ChPH), was used as a substrate for pancreatic cholesterylester hydrolase (CEH, EC 3.1.1.13). Cholesterol Esters 14-30 carboxylesterase 1 Homo sapiens 119-145 4006035-1 1985 A fluorescent cholesterylester analogue, cholesteryl 6-pyrenylhexanoate (ChPH), was used as a substrate for pancreatic cholesterylester hydrolase (CEH, EC 3.1.1.13). Cholesterol Esters 14-30 carboxylesterase 1 Homo sapiens 147-150 32433613-3 2020 The ER enzyme sterol O-acyltransferase 1 (also named acyl-coenzyme A:cholesterol acyltransferase, ACAT1) transfers a long-chain fatty acid to cholesterol to form cholesteryl esters that coalesce into cytosolic lipid droplets. Cholesterol Esters 162-180 carboxylesterase 1 Homo sapiens 53-96 31175950-1 2019 Human carboxylesterase 1 (CES1), primarily expressed in the liver and adipocytes, is responsible for the hydrolysis of endogenous esters (such as cholesteryl esters and triacylglycerols) and the metabolism of xenobiotic esters (such as clopidogrel and oseltamivir), thus participates in physiological and pathological processes. Cholesterol Esters 146-164 carboxylesterase 1 Homo sapiens 26-30 29210644-3 2018 CES1 inhibitors have potential applications in the treatment of hypertriglyceridaemia, obesity and type 2 diabetes, owing to that this enzyme plays prominent role in the metabolism of cholesteryl esters. Cholesterol Esters 184-202 carboxylesterase 1 Homo sapiens 0-4 31262860-1 2019 Overexpression of acyl-coenzyme A:cholesterol acyltransferase (ACAT) results in increased cholesteryl ester levels and has been involved in a variety of cancer types. Cholesterol Esters 90-107 carboxylesterase 1 Homo sapiens 18-61 31262860-1 2019 Overexpression of acyl-coenzyme A:cholesterol acyltransferase (ACAT) results in increased cholesteryl ester levels and has been involved in a variety of cancer types. Cholesterol Esters 90-107 carboxylesterase 1 Homo sapiens 63-67 29247837-8 2018 PAF activated cholesterol ester hydrolases (CEH), enzymes that released cholesterol from stores of cholesterol esters. Cholesterol Esters 99-117 carboxylesterase 1 Homo sapiens 14-42 29247837-8 2018 PAF activated cholesterol ester hydrolases (CEH), enzymes that released cholesterol from stores of cholesterol esters. Cholesterol Esters 99-117 carboxylesterase 1 Homo sapiens 44-47 22262001-7 2012 SUMMARY: The observed beneficial effects of CEH overexpression identify macrophage cholesteryl ester hydrolysis as an important therapeutic target and future studies will determine whether similar effects are obtained with overexpression of HSL or KIAA1363/NCEH1. Cholesterol Esters 83-100 carboxylesterase 1 Homo sapiens 44-47 24051439-1 2013 The proposed method determines the activity of cholesterol esterase (CEH) and takes advantage of its ability to catalyze the hydrolysis of cholesterol esters naturally present in human serum. Cholesterol Esters 139-157 carboxylesterase 1 Homo sapiens 69-72 20609360-1 2010 Acyl coenzyme A:cholesterol acyltransferase (ACAT) catalyzes the intracellular synthesis of cholesteryl esters (CE). Cholesterol Esters 92-110 carboxylesterase 1 Homo sapiens 0-43 20422440-1 2010 At least five families of mammalian carboxylesterases (CES) catalyse the hydrolysis or transesterification of a wide range of drugs and xenobiotics and may also participate in fatty acyl and cholesterol ester metabolism. Cholesterol Esters 191-208 carboxylesterase 1 Homo sapiens 36-53 19761868-4 2010 The cholesteryl ester hydrolysis activity in human macrophages has been attributed to CES1. Cholesterol Esters 4-21 carboxylesterase 1 Homo sapiens 86-90 18925970-7 2008 In addition, taurine reduced the synthesis of cellular cholesterol ester and its secretion, suggesting the inhibition of acyl-coenzyme A:cholesterol acyltransferase activity. Cholesterol Esters 55-72 carboxylesterase 1 Homo sapiens 121-164 19644050-2 2009 Macrophage foam cell formation, characterized by cholesterol ester accumulation, is modulated by scavenger receptor class A (SR-A), acyl-coenzyme A:cholesterol acyltransferase (ACAT)1, and ATP-binding cassette transporter (ABC)A1. Cholesterol Esters 49-66 carboxylesterase 1 Homo sapiens 132-175 18762277-1 2008 Cholesteryl esters are hydrolyzed by cholesteryl ester hydrolase (CEH) yielding free cholesterol for export from macrophages. Cholesterol Esters 0-18 carboxylesterase 1 Homo sapiens 37-64 18762277-1 2008 Cholesteryl esters are hydrolyzed by cholesteryl ester hydrolase (CEH) yielding free cholesterol for export from macrophages. Cholesterol Esters 0-18 carboxylesterase 1 Homo sapiens 66-69 16962139-2 2006 It has been implicated in a variety of endogenous cholesterol metabolism pathways including the following apparently disparate reactions: cholesterol ester hydrolysis (CEH), fatty acyl Coenzyme A hydrolysis (FACoAH), acyl-Coenzyme A:cholesterol acyltransfer (ACAT), and fatty acyl ethyl ester synthesis (FAEES). Cholesterol Esters 138-155 carboxylesterase 1 Homo sapiens 168-171 17950700-1 2007 Acyl-coenzyme A:cholesterol acyltransferase (ACAT) catalyzes the synthesis of cholesteryl esters from cholesterol and long-chain fatty acids. Cholesterol Esters 78-96 carboxylesterase 1 Homo sapiens 0-43 17950700-1 2007 Acyl-coenzyme A:cholesterol acyltransferase (ACAT) catalyzes the synthesis of cholesteryl esters from cholesterol and long-chain fatty acids. Cholesterol Esters 78-96 carboxylesterase 1 Homo sapiens 45-49 17412327-1 2007 Previous studies have shown that acyl-coenzyme A:cholesterol acyl transferase (ACAT), an enzyme that controls cellular equilibrium between free cholesterol and cholesteryl esters, modulates proteolytic processing of APP in cell-based and animal models of Alzheimer"s disease. Cholesterol Esters 160-178 carboxylesterase 1 Homo sapiens 33-77 17237500-4 2007 Lack of TGH activity was accompanied by accumulation of cellular triacylglycerols and cholesteryl esters without any changes in the expression of enzymes catalyzing triacylglycerol synthesis (diacylglycerol acyltransferases 1 and 2) or degradation (adipose triglyceride lipase and hormone-sensitive lipase). Cholesterol Esters 86-104 carboxylesterase 1 Homo sapiens 8-11 18466422-4 2008 The action of acyl-coenzyme A (CoA): cholesterol acyltransferase (ACAT) leads to formation of cholesterol esters. Cholesterol Esters 94-112 carboxylesterase 1 Homo sapiens 14-64 16971496-2 2007 Since extracellular cholesterol acceptor-mediated cholesterol efflux is the only recognized mechanism of cholesterol removal from foam cells and this process is rate limited at the level of intracellular cholesterol ester hydrolysis, a reaction catalyzed by neutral cholesteryl ester hydrolase (CEH), we examined the hypothesis that CEH overexpression in the human macrophage monocyte/macrophage cell line THP1 results in increased cholesterol efflux, as well as decreased cellular cholesterol ester accumulation. Cholesterol Esters 204-221 carboxylesterase 1 Homo sapiens 266-293 16971496-2 2007 Since extracellular cholesterol acceptor-mediated cholesterol efflux is the only recognized mechanism of cholesterol removal from foam cells and this process is rate limited at the level of intracellular cholesterol ester hydrolysis, a reaction catalyzed by neutral cholesteryl ester hydrolase (CEH), we examined the hypothesis that CEH overexpression in the human macrophage monocyte/macrophage cell line THP1 results in increased cholesterol efflux, as well as decreased cellular cholesterol ester accumulation. Cholesterol Esters 204-221 carboxylesterase 1 Homo sapiens 295-298 16971496-2 2007 Since extracellular cholesterol acceptor-mediated cholesterol efflux is the only recognized mechanism of cholesterol removal from foam cells and this process is rate limited at the level of intracellular cholesterol ester hydrolysis, a reaction catalyzed by neutral cholesteryl ester hydrolase (CEH), we examined the hypothesis that CEH overexpression in the human macrophage monocyte/macrophage cell line THP1 results in increased cholesterol efflux, as well as decreased cellular cholesterol ester accumulation. Cholesterol Esters 204-221 carboxylesterase 1 Homo sapiens 333-336 16971496-7 2007 CEH overexpression, therefore, not only enhances cholesterol efflux but also reduces cellular accumulation of cholesteryl esters. Cholesterol Esters 110-128 carboxylesterase 1 Homo sapiens 0-3 16832167-2 2006 RECENT FINDINGS: ACAT inhibitors decrease the intracellular conversion of free cholesterol into cholesteryl ester in a number of tissues, including intestine, liver and macrophages. Cholesterol Esters 96-113 carboxylesterase 1 Homo sapiens 17-21 16503866-1 2005 Acyl-coenzyme A: cholesterol acyltransferase (ACAT) is an intracellular enzyme that catalyzes the formation of cholesterol esters from cholesterol and fatty acyl-coenzyme A. Cholesterol Esters 111-129 carboxylesterase 1 Homo sapiens 0-44 16503866-1 2005 Acyl-coenzyme A: cholesterol acyltransferase (ACAT) is an intracellular enzyme that catalyzes the formation of cholesterol esters from cholesterol and fatty acyl-coenzyme A. Cholesterol Esters 111-129 carboxylesterase 1 Homo sapiens 46-50 16753029-3 2006 Excess cellular cholesterol is converted to cholesteryl esters by the enzyme acyl-coenzyme A:cholesterol acyltransferase (ACAT) 1 or is removed from a cell by cellular cholesterol efflux at the plasma membrane. Cholesterol Esters 44-62 carboxylesterase 1 Homo sapiens 77-129 19804136-2 2006 Most of the cholesteryl esters in macrophage foam cells are produced by the enzyme acyl-coenzyme A:cholesterol acyltransferase (ACAT). Cholesterol Esters 12-30 carboxylesterase 1 Homo sapiens 83-126