PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
12388190-2	2003	In the present study, the role of a highly conserved Trp residue at position 1242 on MRP3 transport function was examined by expressing wild-type MRP3 and Ala-, Cys-, Phe-, Tyr-, and Pro-substituted mutants in human embryonic kidney 293T cells.	Tryptophan	53-56	ATP binding cassette subfamily B member 4	Homo sapiens	85-89	
12388190-2	2003	In the present study, the role of a highly conserved Trp residue at position 1242 on MRP3 transport function was examined by expressing wild-type MRP3 and Ala-, Cys-, Phe-, Tyr-, and Pro-substituted mutants in human embryonic kidney 293T cells.	Tryptophan	53-56	ATP binding cassette subfamily B member 4	Homo sapiens	146-150	
12388190-3	2003	Four MRP3-Trp(1242) mutants showed significantly increased E(2)17betaG uptake, whereas transport by the Pro mutant was undetectable.	Tryptophan	10-13	ATP binding cassette subfamily B member 4	Homo sapiens	5-9	
12388190-7	2003	In contrast, the MRP3-Trp(1242) substitutions did not significantly affect taurocholate transport or taurocholate and glycocholate inhibition of E(2)17betaG uptake.	Tryptophan	22-25	ATP binding cassette subfamily B member 4	Homo sapiens	17-21	
12388190-8	2003	Thus Trp(1242) substitutions markedly alter the substrate specificity of MRP3 but leave bile salt binding and transport intact.	Tryptophan	5-8	ATP binding cassette subfamily B member 4	Homo sapiens	73-77	
34385322-6	2021	Its choline moiety is stabilized by cation-pi interactions with an essential tryptophan residue, rationalizing the specificity of ABCB4 for phosphatidylcholine.	Tryptophan	77-87	ATP binding cassette subfamily B member 4	Homo sapiens	130-135	
34385322-8	2021	Using a proteoliposome-based translocation assay with fluorescently labeled phosphatidylcholine analogs, we recapitulated the substrate specificity of ABCB4 in vitro and confirmed the role of the key tryptophan residue.	Tryptophan	200-210	ATP binding cassette subfamily B member 4	Homo sapiens	151-156