PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 9353194-1 1997 Remodeling of the interface between human growth hormone (hGH) and the extracellular domain of its receptor was studied by deleting a critical tryptophan residue (at position 104) in the receptor, creating a large cavity, and selecting a pentamutant of hGH by phage display that fills the cavity and largely restores binding affinity. Tryptophan 143-153 growth hormone 1 Homo sapiens 42-56 25125795-3 1998 The intensity, spectra, and quenching of the intrinsic fluorescence emitted by the growth hormone"s single tryptophan are monitored and related to adsorption kinetics and protein conformation. Tryptophan 107-117 growth hormone 1 Homo sapiens 83-97 8766941-1 1996 A clinical, prospective experiment was carried out to determine whether long-term intranasal administration of the growth hormone-releasing peptide hexarelin (His-D-2-methyl-Trp-Ala-Trp-D-Phe -Lys-NH2) affects pituitary growth hormone secretion. Tryptophan 174-177 growth hormone 1 Homo sapiens 115-129 7920995-2 1993 Recently, a new GH-releasing hexapeptide (His-D-Trp-Ala-Trp-D-Phe-Lys-NH2) called GHRP-6 which specifically releases GH has been studied. Tryptophan 48-51 growth hormone 1 Homo sapiens 16-18 7920995-2 1993 Recently, a new GH-releasing hexapeptide (His-D-Trp-Ala-Trp-D-Phe-Lys-NH2) called GHRP-6 which specifically releases GH has been studied. Tryptophan 56-59 growth hormone 1 Homo sapiens 16-18 3337615-6 1988 The cortisol and growth hormone responses to MCPP and tryptophan were similar in the patients and healthy subjects and were not related to gender. Tryptophan 54-64 growth hormone 1 Homo sapiens 17-31 8503009-3 1993 The mechanism of action of L-692,429 and studies with peptidyl and nonpeptidyl antagonists suggest that this molecule is a mimic of the growth hormone-releasing hexapeptide His-D-Trp-Ala-Trp-D-Phe-Lys-NH2 (GHRP-6). Tryptophan 179-182 growth hormone 1 Homo sapiens 136-150 8503009-3 1993 The mechanism of action of L-692,429 and studies with peptidyl and nonpeptidyl antagonists suggest that this molecule is a mimic of the growth hormone-releasing hexapeptide His-D-Trp-Ala-Trp-D-Phe-Lys-NH2 (GHRP-6). Tryptophan 187-190 growth hormone 1 Homo sapiens 136-150 1772093-0 1991 Endocrine response of prolactin, cortisol, and growth hormone to low dose intravenous L-tryptophan in healthy subjects during day and night. Tryptophan 86-98 growth hormone 1 Homo sapiens 47-61 2682610-2 1989 Both W86Y hGH and delta W86 hGH have a point mutation at Trp86 which is the only Trp residue in hGH and is conserved among members of the growth hormone family. Tryptophan 57-60 growth hormone 1 Homo sapiens 138-152 1829742-0 1991 Blunted growth hormone and prolactin responses to L-tryptophan in depression; a state-dependent abnormality. Tryptophan 50-62 growth hormone 1 Homo sapiens 8-22 1829742-1 1991 We have investigated whether attenuated growth hormone (GH) and prolactin (PRL) responses to L-tryptophan in depression return to normal with clinical recovery. Tryptophan 93-105 growth hormone 1 Homo sapiens 40-54 2006240-0 1991 Pindolol decreases prolactin and growth hormone responses to intravenous L-tryptophan. Tryptophan 73-85 growth hormone 1 Homo sapiens 33-47 3090598-4 1986 The results demonstrate a stimulatory effect of L-tryptophan on prolactin and growth hormone secretion, and the former is facilitated by pretreatment with dexamethasone. Tryptophan 48-60 growth hormone 1 Homo sapiens 78-92 2887003-1 1987 The growth hormone (GH) and prolactin (PRL) responses to intravenous L-tryptophan (LTP) were measured in 20 schizophrenics receiving long-term treatment with neuroleptics and 20 unmedicated control subjects. Tryptophan 69-81 growth hormone 1 Homo sapiens 4-18 3081933-2 1986 Significant increases were observed in plasma concentrations of growth hormone and prolactin after all three doses of L-tryptophan, but not after saline infusion. Tryptophan 118-130 growth hormone 1 Homo sapiens 64-78 3675135-2 1987 The increases in the growth hormone (GH) level following intravenous infusion of the 5-hydroxytryptamine precursor tryptophan, the alpha 2-adrenoceptor agonist clonidine hydrochloride, and subcutaneous injection of the dopamine agonist apomorphine hydrochloride were determined in volunteers before and in the third week of a weight-reducing diet (1200 kcal/d). Tryptophan 115-125 growth hormone 1 Homo sapiens 21-35 3675136-1 1987 The increases in plasma levels of prolactin (PRL) and growth hormone (GH) following intravenous administration of the 5-hydroxytryptamine precursor tryptophan (100 mg/kg) were assessed in 30 depressed patients and 30 control subjects. Tryptophan 148-158 growth hormone 1 Homo sapiens 54-68 3675136-4 1987 Growth hormone responses to tryptophan were significantly decreased in patients who lost less than 10 lb. Tryptophan 28-38 growth hormone 1 Homo sapiens 0-14 3628621-2 1987 An acute dose of diazepam (15 mg) significantly attenuated the prolactin and growth hormone responses to intravenous L-tryptophan. Tryptophan 117-129 growth hormone 1 Homo sapiens 77-91 3016787-0 1986 Clomipramine enhances prolactin and growth hormone responses to L-tryptophan. Tryptophan 64-76 growth hormone 1 Homo sapiens 36-50 3097730-1 1986 The effect of lithium on serotonin (5-HT)-mediated responses in the brain was assessed by measuring changes in the prolactin (PRL) and growth hormone (GH) responses to L-tryptophan (LTP) in eight normal subjects. Tryptophan 168-180 growth hormone 1 Homo sapiens 135-149 3097730-1 1986 The effect of lithium on serotonin (5-HT)-mediated responses in the brain was assessed by measuring changes in the prolactin (PRL) and growth hormone (GH) responses to L-tryptophan (LTP) in eight normal subjects. Tryptophan 168-180 growth hormone 1 Homo sapiens 151-153 6139243-3 1983 Injection of the serotonin precursor tryptophan and the serotonin re-uptake blocker imipramine resulted in elevated prolactin and reduced growth hormone levels. Tryptophan 37-47 growth hormone 1 Homo sapiens 138-152 2991963-0 1985 Responses of prolactin and growth hormone to L-tryptophan infusion: effects in normal subjects and schizophrenic patients receiving neuroleptics. Tryptophan 45-57 growth hormone 1 Homo sapiens 27-41 2991963-1 1985 Intravenous infusion of L-tryptophan (LTP) in 18 normal subjects produced a significant increase in plasma prolactin (PRL), growth hormone (GH), and self-ratings of drowsiness. Tryptophan 24-36 growth hormone 1 Homo sapiens 124-138 6465896-1 1984 Second-order absorption spectra strongly suggest the presence of a hydrogen bond between the single Trp of human pituitary growth hormone (hGH) and a carboxylate ion. Tryptophan 100-103 growth hormone 1 Homo sapiens 113-137 429511-0 1979 Absent growth hormone response to L-tryptophan in acromegaly. Tryptophan 34-46 growth hormone 1 Homo sapiens 7-21 6812143-0 1982 The effect of intravenous L-tryptophan on prolactin and growth hormone and mood in healthy subjects. Tryptophan 26-38 growth hormone 1 Homo sapiens 56-70 7208604-0 1980 Effect of L-tryptophan on apomorphine-induced growth hormone secretion in normal subjects. Tryptophan 10-22 growth hormone 1 Homo sapiens 46-60 6793694-1 1981 The effects of L-deprenyl on L-dopa-, apomorphine- and L-tryptophan-induced growth hormone (GH) secretion were studied in thirteen healthy male volunteers. Tryptophan 55-67 growth hormone 1 Homo sapiens 76-90 6793694-1 1981 The effects of L-deprenyl on L-dopa-, apomorphine- and L-tryptophan-induced growth hormone (GH) secretion were studied in thirteen healthy male volunteers. Tryptophan 55-67 growth hormone 1 Homo sapiens 92-94 447817-0 1979 Effect of melatonin on L-tryptophan- and apomorphine-stimulated growth hormone secretion in man. Tryptophan 23-35 growth hormone 1 Homo sapiens 64-78 5086543-0 1972 Comparative studies of the single tryptophan residue in human chorionic somatomammotropin and human pituitary growth hormone. Tryptophan 34-44 growth hormone 1 Homo sapiens 100-124 4546052-0 1974 Slight effect of L-tryptophan on growth hormone release in normal human subjects. Tryptophan 17-29 growth hormone 1 Homo sapiens 33-47 437678-0 1979 Effect of L-tryptophan on growth hormone and prolactin release in normal volunteers and patients with secretory pituitary tumors. Tryptophan 10-22 growth hormone 1 Homo sapiens 26-40 979991-0 1976 L-Tryptophan administration in man: effects on gonadotrophin, growth hormone and cortisol secretion and on sexual motivation. Tryptophan 0-12 growth hormone 1 Homo sapiens 62-76 979991-3 1976 Short-lasting loading of L-tryptophan caused a statistically significant increase of plasma growth hormone levels, and a fall of plasma cortisol values in neurologic patients without neuroendocrine disorders. Tryptophan 25-37 growth hormone 1 Homo sapiens 92-106 20641841-0 2004 (111)In-Tetraazacyclododecane-N,N",N"",N"""-tetraacetic acid-Phe(4-NO2)-cyclo(D-Cys-Tyr-D-Trp-Lys-Thr-Cys)-D-Tyr-NH2 Somatostatin (SST) is an inhibitor of the release of somatotropin, glucagon, insulin, gastrointestinal hormones, and other secretory proteins (1). Tryptophan 89-93 growth hormone 1 Homo sapiens 170-182 25626070-5 2015 Secondary structure analysis of GH-1 revealed 54% alpha-helical content in a lipid-free state and 65% alpha-helical content in a lipid-bound state along with blue-shifted tryptophan movement (around 2 nm). Tryptophan 171-181 growth hormone 1 Homo sapiens 32-36 18225564-1 2007 BACKGROUND: The somatostatin structural deivative, TT-232, has a special 5"-residue ring structure (D-Phe-Cys-Tyr-D-Trp-Lys-Cys-Thr-NH2) and very different characteristics from the known growth hormone (GH) active somatostatin analogs. Tryptophan 116-119 growth hormone 1 Homo sapiens 187-201 18225564-1 2007 BACKGROUND: The somatostatin structural deivative, TT-232, has a special 5"-residue ring structure (D-Phe-Cys-Tyr-D-Trp-Lys-Cys-Thr-NH2) and very different characteristics from the known growth hormone (GH) active somatostatin analogs. Tryptophan 116-119 growth hormone 1 Homo sapiens 203-205 12450642-6 2002 RESULTS: The GH response to TRP was significantly lower in the recovered depressed patients than controls after hydrocortisone. Tryptophan 28-31 growth hormone 1 Homo sapiens 13-15 12787021-5 2003 In Anx(Gh1), the conserved tryptophan residue is in a surface-exposed position, half way between both conformations observed in Anx24(Ca32). Tryptophan 27-37 growth hormone 1 Homo sapiens 7-10 10227081-3 1999 Evidence suggests that the growth hormone (GH) response to L-tryptophan (L-TRP) is mediated by 5-HT1A receptors. Tryptophan 59-71 growth hormone 1 Homo sapiens 27-41 10227081-3 1999 Evidence suggests that the growth hormone (GH) response to L-tryptophan (L-TRP) is mediated by 5-HT1A receptors. Tryptophan 73-78 growth hormone 1 Homo sapiens 27-41 11041314-1 2000 RATIONALE: In depression, the growth hormone (GH) response to clonidine and L-tryptophan (L-TRP) is reduced, suggesting reduced alpha2-adrenergic and serotonin (5-HT)1A receptor function. Tryptophan 76-88 growth hormone 1 Homo sapiens 30-44 11041314-1 2000 RATIONALE: In depression, the growth hormone (GH) response to clonidine and L-tryptophan (L-TRP) is reduced, suggesting reduced alpha2-adrenergic and serotonin (5-HT)1A receptor function. Tryptophan 76-88 growth hormone 1 Homo sapiens 46-48 11041314-1 2000 RATIONALE: In depression, the growth hormone (GH) response to clonidine and L-tryptophan (L-TRP) is reduced, suggesting reduced alpha2-adrenergic and serotonin (5-HT)1A receptor function. Tryptophan 90-95 growth hormone 1 Homo sapiens 30-44 11041314-1 2000 RATIONALE: In depression, the growth hormone (GH) response to clonidine and L-tryptophan (L-TRP) is reduced, suggesting reduced alpha2-adrenergic and serotonin (5-HT)1A receptor function. Tryptophan 90-95 growth hormone 1 Homo sapiens 46-48 11041314-2 2000 Pretreatment with hydrocortisone (100 mg, orally 11 h before) also blunts the GH response to L-TRP. Tryptophan 93-98 growth hormone 1 Homo sapiens 78-80 10525755-3 1999 In humans, the growth hormone (GH) response to intravenous l-tryptophan (IV l-TRP) is blocked by the 5-HT(1A) antagonist pindolol and the prolactin response is blunted. Tryptophan 59-71 growth hormone 1 Homo sapiens 15-29 10525755-3 1999 In humans, the growth hormone (GH) response to intravenous l-tryptophan (IV l-TRP) is blocked by the 5-HT(1A) antagonist pindolol and the prolactin response is blunted. Tryptophan 76-81 growth hormone 1 Homo sapiens 15-29