PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 8828061-3 1996 Ingestion of carbohydrate foods stimulates insulin secretion which accelerates the uptake of tryptophan, the precursor of 5-HT and melatonin, into the brain and pineal gland, respectively. Tryptophan 93-103 insulin Homo sapiens 43-50 9030829-1 1997 Prompted by the recent findings that a tryptophan to arginine (Trp64Arg) mutation in the beta3-adrenergic receptor gene was associated with an earlier onset of non-insulin-dependent diabetes mellitus (NIDDM) in Pima Indians, with abdominal obesity and insulin resistance in Finns, and with an increased capacity to gain weight in French whites, we studied the prevalence of this mutation in 231 diabetic and 95 nondiabetic Japanese subjects and assessed its contribution to the development of obesity and NIDDM. Tryptophan 39-49 insulin Homo sapiens 164-171 9054578-3 1997 We monitored the time course of the anisotropy change, and these data, coupled with studies monitoring the energy transfer from insulin receptor tryptophan donors to a fluorescent-labeled insulin, allowed us to conclude that the change in anisotropy is due to a conformational change in the receptor induced by hormone binding. Tryptophan 145-155 insulin Homo sapiens 128-135 9054578-3 1997 We monitored the time course of the anisotropy change, and these data, coupled with studies monitoring the energy transfer from insulin receptor tryptophan donors to a fluorescent-labeled insulin, allowed us to conclude that the change in anisotropy is due to a conformational change in the receptor induced by hormone binding. Tryptophan 145-155 insulin Homo sapiens 188-195 7654714-1 1995 A conformational change, termed the T --> R transition, which can be detected by visible, circular dichoric, and fluorescence spectroscopy, occurs in native insulin and tryptophan substituted insulin analogs ([TrpB25]-, [TrpB26]-, [GlyB24,TrpB25]-, and [GlyB24,TrpB26]insulin) upon binding specific alcohol ligands, including phenol and cyclohexanol. Tryptophan 172-182 insulin Homo sapiens 195-202 7654714-1 1995 A conformational change, termed the T --> R transition, which can be detected by visible, circular dichoric, and fluorescence spectroscopy, occurs in native insulin and tryptophan substituted insulin analogs ([TrpB25]-, [TrpB26]-, [GlyB24,TrpB25]-, and [GlyB24,TrpB26]insulin) upon binding specific alcohol ligands, including phenol and cyclohexanol. Tryptophan 172-182 insulin Homo sapiens 195-202 2184899-6 1990 The baseline disposal of L-TRP was related neither to insulin nor to FFA concentrations Dexamethasone administration significantly reduced the L-TRP and L-TRP/CAA values and increased FFA and insulin levels. Tryptophan 25-30 insulin Homo sapiens 192-199 7662110-3 1995 This insulin is spectrally enhanced since 5-hydroxytryptophan has an absorption band above 300 nm which is at lower energies than the absorption of tryptophan. Tryptophan 51-61 insulin Homo sapiens 5-12 7838010-4 1994 Additionally, it is well known that insulin enhances serotonergic activity in increasing blood-brain barrier transport of tryptophan. Tryptophan 122-132 insulin Homo sapiens 36-43 8054322-4 1994 Mean integrated insulin, gastric inhibitory polypeptide (GIP) and glucose concentrations were higher after the C diets compared with the F diets, TRP supplementation globally augmented ks linearly in the liver, ST, skin and whole body, while it had quadratic effects in the LD (ks highest in the TRP-adequate diet groups) and jejunal mucosa (ks lowest in the TRP-adequate diet groups). Tryptophan 146-149 insulin Homo sapiens 16-55 1722997-0 1991 Effect of dietary tryptophan on muscle, liver and whole-body protein synthesis in weaned piglets: relationship to plasma insulin. Tryptophan 18-28 insulin Homo sapiens 121-128 1722997-9 1991 After a further 30 min the appearance of a similar significant effect of the TRP x LF interaction on plasma insulin resulted from its abatement when the deficient diet had been fed at high LF. Tryptophan 77-80 insulin Homo sapiens 108-115 1722997-10 1991 These results suggest that dietary TRP deficiency decreased muscle and liver protein synthesis rates in relation to a decrease in the post-prandial release of insulin following a decreased rate of nutrient absorption. Tryptophan 35-38 insulin Homo sapiens 159-166 7662110-1 1995 Use of insulin"s intrinsic tyrosine absorption and fluorescence to monitor its interaction with the insulin receptor is limited because the spectral properties of the receptor tryptophan residues mask the spectral properties of the hormone tyrosine residues. Tryptophan 176-186 insulin Homo sapiens 7-14 7662110-2 1995 We describe the synthesis of an insulin analog where A14 tyrosine is replaced by a tryptophan analog, 5-hydroxytryptophan. Tryptophan 83-93 insulin Homo sapiens 32-39 7765581-1 1994 A pseudohuman proinsulin coding DNA sequence (MMRPI) carrying human A and B chains, was constructed via directed mutagenesis of a previously modified rat proinsulin cDNA (MRPI) and expressed as a tryptophan (Trp)LE-proinsulin fusion protein in Escherichia coli W3110. Tryptophan 196-206 insulin Homo sapiens 14-24 8136024-2 1993 [B16 Phe]insulin and [B16 Trp]insulin display a very modest reduction in potency (c. 65%) relative to porcine insulin; [B26 Phe]insulin is less active (30-50%), and the doubly substituted [B16 Phe, B26 Phe]insulin displays still lower potency (c. 35%). Tryptophan 26-29 insulin Homo sapiens 30-37 8136024-2 1993 [B16 Phe]insulin and [B16 Trp]insulin display a very modest reduction in potency (c. 65%) relative to porcine insulin; [B26 Phe]insulin is less active (30-50%), and the doubly substituted [B16 Phe, B26 Phe]insulin displays still lower potency (c. 35%). Tryptophan 26-29 insulin Homo sapiens 30-37 8136024-2 1993 [B16 Phe]insulin and [B16 Trp]insulin display a very modest reduction in potency (c. 65%) relative to porcine insulin; [B26 Phe]insulin is less active (30-50%), and the doubly substituted [B16 Phe, B26 Phe]insulin displays still lower potency (c. 35%). Tryptophan 26-29 insulin Homo sapiens 30-37 8136024-2 1993 [B16 Phe]insulin and [B16 Trp]insulin display a very modest reduction in potency (c. 65%) relative to porcine insulin; [B26 Phe]insulin is less active (30-50%), and the doubly substituted [B16 Phe, B26 Phe]insulin displays still lower potency (c. 35%). Tryptophan 26-29 insulin Homo sapiens 30-37 3076266-0 1988 Studies on the crystal structure of A1-(L-tryptophan) insulin at 2.1 A resolution. Tryptophan 42-52 insulin Homo sapiens 54-61 34289446-8 2021 CONCLUSIONS: The lncRNAs ERMP1,TSPAN32 and MRPL38 form a co-expression network with TPH1, which is mainly involved in the tryptophan metabolism pathway and in the development of GDM, Moreover, lncRNA RPL13P5 forms a co-expression network with the TSC2 gene via the pi3k-akt and insulin signalling pathways, which are involved in the process of insulin resistance in GDM. Tryptophan 122-132 insulin Homo sapiens 344-351 35247461-0 2022 Gut Microbiota Reprogramming f Tryptophan Metabolism During Pregnancy Shapes Host Insulin Resistance. Tryptophan 31-41 insulin Homo sapiens 82-89 35065080-9 2022 C12 + TRP and C12 delayed the rise in C-peptide and insulin, and also stimulated CCK and glucagon, compared with control and TRP (all P < 0.05). Tryptophan 6-9 insulin Homo sapiens 52-59 2686652-2 1989 The proinsulin gene has been expressed directly under the control of a synthetic promoter of phage fd DNA and a promoter of tryptophan operon, or using fusions with fragments of some bacterial proteins. Tryptophan 124-134 insulin Homo sapiens 4-14 3915598-0 1985 The growth of single crystal and the determination of crystallographic parameters of (L-tryptophan)A1-insulin and (D-tryptophan)A1-insulin. Tryptophan 85-98 insulin Homo sapiens 102-109 3745176-5 1986 Chemical cleavage at either tryptophan or methionine residues followed by immunoprecipitation with antipeptide antibodies was used to map the in vitro autophosphorylation sites of the beta subunit of the insulin receptor. Tryptophan 28-38 insulin Homo sapiens 204-211 2975197-5 1988 Treatment of animals with STZ markedly increased the activation, by liver microsomes in vitro, of Trp-P-1 and Trp-P-2 to mutagens, the effect being totally preventable by nicotinamide and successfully antagonised with insulin therapy. Tryptophan 98-101 insulin Homo sapiens 218-225 3600282-5 1987 Both tryptophan and LNAA levels decreased in an insulin dose-dependent manner (P less than .02). Tryptophan 5-15 insulin Homo sapiens 48-55 3600282-6 1987 The dose-response effect of insulin on tryptophan levels in the elderly was less than in the young (P less than .03), while the response of the LNAA was similar in both age groups. Tryptophan 39-49 insulin Homo sapiens 28-35 3600282-7 1987 The ratio of tryptophan to LNAA was less in the old when compared to the young (P less than .03) but increased in the two age groups in an insulin-dose-dependent fashion (P less than .02). Tryptophan 13-23 insulin Homo sapiens 139-146 3306438-2 1987 Insulin was enhanced in the intermittent explosive disorder; at the same time the concentration of plasma tryptophan and the ratio of tryptophan to large neutral amino acids were on a high level and tryptophan even increased in many cases during GTT. Tryptophan 106-116 insulin Homo sapiens 0-7 3306438-2 1987 Insulin was enhanced in the intermittent explosive disorder; at the same time the concentration of plasma tryptophan and the ratio of tryptophan to large neutral amino acids were on a high level and tryptophan even increased in many cases during GTT. Tryptophan 134-144 insulin Homo sapiens 0-7 3306438-2 1987 Insulin was enhanced in the intermittent explosive disorder; at the same time the concentration of plasma tryptophan and the ratio of tryptophan to large neutral amino acids were on a high level and tryptophan even increased in many cases during GTT. Tryptophan 134-144 insulin Homo sapiens 0-7 3890175-0 1985 Fluorescence properties of insulin analogs with tryptophan substitutions. Tryptophan 48-58 insulin Homo sapiens 27-34 3890175-2 1985 The effect of pH on the fluorescence behaviours of the three L-Trp insulin analogs are similar to only one fluorescence intensity peak at pH 9. Tryptophan 61-66 insulin Homo sapiens 67-74 6400041-5 1984 Insulin, in turn, decreases plasma levels of large neutral amino acids that would ordinarily compete with tryptophan for transport across the blood-brain barrier. Tryptophan 106-116 insulin Homo sapiens 0-7 6315437-2 1983 Antibodies to proinsulin chimeric protein (human proinsulin coupled at its amino-terminus to a portion of the E. coli tryptophan E gene product) were localized in E. coli using post-embedding staining with protein A-peroxidase labelling for transmission electron microscopy. Tryptophan 118-128 insulin Homo sapiens 14-24 6351935-0 1983 Free tryptophan response to intravenous insulin in depressed patients. Tryptophan 5-15 insulin Homo sapiens 40-47 6351935-3 1983 However, following insulin, free plasma tryptophan levels fell significantly among the patients with major depressive disorder for the first 30 min, but not among normal controls. Tryptophan 40-50 insulin Homo sapiens 19-26 458726-0 1979 Effect of insulin upon levels of amino acids in the blood and upon the influx of tryptophan into the brain [proceedings]. Tryptophan 81-91 insulin Homo sapiens 10-17 660197-0 1978 Does insulin act directly on the brain to increase tryptophan levels? Tryptophan 51-61 insulin Homo sapiens 5-12 979999-0 1976 Insulin secretion in migraine: influence on the blood levels of tryptophan. Tryptophan 64-74 insulin Homo sapiens 0-7 594070-0 1977 Effect of insulin on human plasma tryptophan and nonesterified fatty acids. Tryptophan 34-44 insulin Homo sapiens 10-17 941747-0 1976 Possible role of insulin in the transport of tyrosine and tryptophan from blood to brain. Tryptophan 58-68 insulin Homo sapiens 17-24 941747-1 1976 The administration of insulin or the ingestion of glucose increases the concentration of tryptophan and tyrosine in the brain. Tryptophan 89-99 insulin Homo sapiens 22-29 941747-3 1976 The results suggest that insulin enhances the transport of tyrosine and tryptophan from blood to brain. Tryptophan 72-82 insulin Homo sapiens 25-32 941747-4 1976 The results, moreover, suggest that exogenous or endogenous insulin enhances the transport of tyrosine and tryptophan from blood to brain. Tryptophan 107-117 insulin Homo sapiens 60-67 993793-0 1976 Insulin coma therapy: decrease of plasma tryptophan in man. Tryptophan 41-51 insulin Homo sapiens 0-7 993793-2 1976 The injection of insulin resulted in a decrease of free and total tryptophan as well as tyrosine in plasma, while NEFA were not influenced by this treatment. Tryptophan 66-76 insulin Homo sapiens 17-24 993793-4 1976 The administration of glucose after insulin provoked an increase of free and total tryptophan. Tryptophan 83-93 insulin Homo sapiens 36-43 993793-5 1976 The results support the hypothesis that in man insulin may favor the uptake of tryptophan by the brain, and enhance the synthesis of cerebral serotonin. Tryptophan 79-89 insulin Homo sapiens 47-54 1204766-0 1975 Effects of tryptophan and other amino acids on glucose uptake and carbon dioxide output by the insulin-stimulated adipose tissue. Tryptophan 11-21 insulin Homo sapiens 95-102 1204766-1 1975 Tryptophan (4-10 mM) reduces the stimulating effect of insulin on glucose uptake, CO2 output and lactate production by adipose tissue. Tryptophan 0-10 insulin Homo sapiens 55-62 33352955-9 2020 ATR-FTIR studies showed that there is indeed inter-peptide interaction between C-peptide and the tryptophan residues of the 9mer com-peptides. Tryptophan 97-107 insulin Homo sapiens 79-88 810422-6 1975 In addition, the carbohydrate content of the diet causes tryptophan to become deposited in the free amino acid pool of muscle through an insulin-dependent mechanism. Tryptophan 57-67 insulin Homo sapiens 137-144 4419545-0 1974 The effect of insulin load on plasma tryptophan levels in schizophrenic patients. Tryptophan 37-47 insulin Homo sapiens 14-21 5077329-1 1972 When plasma tryptophan is elevated by the injection of tryptophan or insulin, or by the consumption of carbohydrates, brain tryptophan and serotonin also rise; however, when even larger elevations of plasma tryptophan are produced by the ingestion of protein-containing diets, brain tryptophan and serotonin do not change. Tryptophan 12-22 insulin Homo sapiens 69-76 4893732-0 1968 Insulin releasing activity of oral L-tryptophan in fasting and non-fasting subjects. Tryptophan 35-47 insulin Homo sapiens 0-7 33352955-10 2020 CD studies of unaggregated and colloidal C-peptide with the 9mer com-peptides suggest that the extent of co-assembly of C-peptide with Trp-D is greatest, followed by Lys-D and Lys-L. Tryptophan 135-138 insulin Homo sapiens 120-129 29298881-4 2018 Pathway analysis on the up-regulated gene list untraveled enrichment in multiple signaling pathways including insulin receptor signaling, focal Adhesion, metapathway biotransformation, a number of metabolic pathways e.g. selenium metabolism, Benzo(a)pyrene metabolism, fatty acid, triacylglycerol, ketone body metabolism, tryptophan metabolism, and catalytic cycle of mammalian flavin-containing monooxygenase (FMOs). Tryptophan 322-332 insulin Homo sapiens 110-117 31189717-4 2019 Here, we show that tryptophan-derived metabolites produced by the gut microbiota controlled the expression of the miR-181 family in white adipocytes in mice to regulate energy expenditure and insulin sensitivity. Tryptophan 19-29 insulin Homo sapiens 192-199 30455401-10 2018 This modeling suggested that the core epitope within the pre-proinsulin 9-28 peptide has a somewhat unusual binding motif, with tryptophan in the fourth binding pocket of DRB4, perhaps influencing the availability of this complex for T cell selection. Tryptophan 128-138 insulin Homo sapiens 61-71 29368094-0 2018 Correction to: Tryptophan depletion under conditions that imitate insulin resistance enhances fatty acid oxidation and induces endothelial dysfunction through reactive oxygen species-dependent and independent pathways. Tryptophan 15-25 insulin Homo sapiens 66-73 31913613-3 2020 We report a one-step route to [18F]CF3SO2NH4 from [18F]fluoride and its application to direct [18F]CF3 incorporation at tryptophan or tyrosine residues using unmodified peptides as complex as recombinant human insulin. Tryptophan 120-130 insulin Homo sapiens 210-217 31467335-9 2019 Finally, the unique combination of experimental data and modelling predictions suggested that HFHS feeding was associated with changes in tryptophan metabolism and fatty acid beta-oxidation, which may play an important role in lipid hepatic accumulation and insulin sensitivity. Tryptophan 138-148 insulin Homo sapiens 258-265 28161804-0 2017 Tryptophan depletion under conditions that imitate insulin resistance enhances fatty acid oxidation and induces endothelial dysfunction through reactive oxygen species-dependent and independent pathways. Tryptophan 0-10 insulin Homo sapiens 51-58 28478038-1 2017 CONTEXT: An extensive body of literature indicates a relationship between insulin resistance and the up-regulation of the kynurenine pathway, i.e. the preferential conversion of tryptophan to kynurenine, with subsequent overproduction of diabetogenic downstream metabolites, such as kynurenic acid. Tryptophan 178-188 insulin Homo sapiens 74-81 28161804-11 2017 Thus, TRP depletion, an amino acid whose low levels have been related to worse cardiovascular outcome and to inflammatory atherosclerosis-associated pathologic entities, under conditions that imitate insulin resistance enhances fatty acid oxidation and induces endothelial dysfunction through ROS-dependent and independent pathways. Tryptophan 6-9 insulin Homo sapiens 200-207 27875537-9 2016 RESULTS: Results of the study are: i) L-trp at the higher dose stimulates CCK release (p = 0.0018), and induces a significant retardation in gastric emptying (p = 0.0033); ii) L-trp at the higher dose induced a small increase in GLP-1 secretion (p = 0.0257); iii) neither of the amino acids modulated subjective appetite feelings; and iv) the two amino acids did not alter insulin or glucose concentrations. Tryptophan 38-43 insulin Homo sapiens 373-380 27627133-14 2016 No association was found between tryptophan metabolism and specific dimensions of fatigue, but kynurenine and the kynurenine/tryptophan ratio correlated with insulin and HOMA-IR. Tryptophan 125-135 insulin Homo sapiens 158-165 27627133-15 2016 These data indicate that insulin resistance in non diabetic obese children is associated with both cognitive fatigue and reduced motivation/anhedonia and with alterations in tryptophan metabolism. Tryptophan 174-184 insulin Homo sapiens 25-32 27627133-16 2016 Further investigations are needed to determine whether inflammation-induced alterations in tryptophan metabolism is directly or indirectly implicated in insulin resistance and related fatigue. Tryptophan 91-101 insulin Homo sapiens 153-160 27760995-9 2016 L-tryptophan and L-leucine also modified plasma insulin concentration. Tryptophan 0-12 insulin Homo sapiens 48-55 27760995-10 2016 Finally, significant correlations were found between brain modifications after L-tryptophan administration and insulin plasma levels. Tryptophan 79-91 insulin Homo sapiens 111-118 27285694-14 2016 The peak value of the molar ratio insulin:C-peptide was lower ( < 0.02) in +Trp vs. -Trp piglets (0.56 vs. 0.73, SEM = 0.05). Tryptophan 79-82 insulin Homo sapiens 34-41 27598004-6 2016 Patients with higher tryptophan level tended to present higher degree of insulin resistance and secretion, triglyceride and blood pressure. Tryptophan 21-31 insulin Homo sapiens 73-80 27285694-14 2016 The peak value of the molar ratio insulin:C-peptide was lower ( < 0.02) in +Trp vs. -Trp piglets (0.56 vs. 0.73, SEM = 0.05). Tryptophan 88-91 insulin Homo sapiens 34-41 27285694-17 2016 Postprandial profiles of insulin and C-peptide indicate that Trp action is exerted on insulin clearance rather than on insulin secretion in piglets, without apparent consequences on glucose utilization. Tryptophan 61-64 insulin Homo sapiens 25-32 27285694-17 2016 Postprandial profiles of insulin and C-peptide indicate that Trp action is exerted on insulin clearance rather than on insulin secretion in piglets, without apparent consequences on glucose utilization. Tryptophan 61-64 insulin Homo sapiens 86-93 27285694-17 2016 Postprandial profiles of insulin and C-peptide indicate that Trp action is exerted on insulin clearance rather than on insulin secretion in piglets, without apparent consequences on glucose utilization. Tryptophan 61-64 insulin Homo sapiens 86-93 25990963-7 2015 Rearrangement of tryptophan residues resulted in significantly increased insulin permeation as compared to that of the parent penetratin. Tryptophan 17-27 insulin Homo sapiens 73-80 26878772-2 2016 Brain food, e.g. L-tryptophan, antioxidative substances, B vitamins and magnesium are thought to be beneficial for obesity, inflammation and insulin resistance. Tryptophan 17-29 insulin Homo sapiens 141-148 17940985-1 2007 INTRODUCTION: Some studies indicate, that the Trp(64)/Arg(64) polymorphism of beta(3)-adrenergic receptor (ADRB3) is associated with obesity, insulin resistance and earlier onset of type 2 diabetes mellitus. Tryptophan 46-49 insulin Homo sapiens 142-149 23306210-11 2013 Carbohydrate-rich diet triggers insulin response to enhance the bioavailability of tryptophan in the CNS which is responsible for increased craving of carbohydrate diets. Tryptophan 83-93 insulin Homo sapiens 32-39 19855001-1 2010 The aim of this experiment was to investigate whether insulin resistance is related to the dietary concentration of Trp and the ADFI of primiparous sows having similar body conditions. Tryptophan 116-119 insulin Homo sapiens 54-61 19855001-9 2010 At d 3 of lactation, the insulin concentration at 105 (P = 0.03) and 120 min (P = 0.04) after meal intake was less for the sows allocated to the slight excessive Trp diet than for the sows allocated to the suboptimal Trp diet. Tryptophan 162-165 insulin Homo sapiens 25-32 19855001-9 2010 At d 3 of lactation, the insulin concentration at 105 (P = 0.03) and 120 min (P = 0.04) after meal intake was less for the sows allocated to the slight excessive Trp diet than for the sows allocated to the suboptimal Trp diet. Tryptophan 217-220 insulin Homo sapiens 25-32 19855001-10 2010 On d 10 of lactation, the glucose half life (P = 0.03) and the time needed to reach 25% of the area under the insulin curve (P = 0.04) during the tolerance test were less for the sows allocated to the slight excessive Trp diet than for the sows allocated to the suboptimal Trp diet. Tryptophan 218-221 insulin Homo sapiens 110-117 20641841-0 2004 (111)In-Tetraazacyclododecane-N,N",N"",N"""-tetraacetic acid-Phe(4-NO2)-cyclo(D-Cys-Tyr-D-Trp-Lys-Thr-Cys)-D-Tyr-NH2 Somatostatin (SST) is an inhibitor of the release of somatotropin, glucagon, insulin, gastrointestinal hormones, and other secretory proteins (1). Tryptophan 89-93 insulin Homo sapiens 194-201 25524770-1 2015 OBJECTIVE: Enhanced tryptophan degradation, induced by the proinflammatory cytokine interferon-gamma, has been related to cardiovascular disease progression and insulin resistance. Tryptophan 20-30 insulin Homo sapiens 161-168 24167603-4 2013 By performing Raman spectroscopic measurements on purified insulin and glucagon, we showed that the 520 cm(-1) band assigned to disulfide bridges in insulin, and the 1552 cm(-1) band assigned to tryptophan in glucagon are mutually exclusive and could therefore be used as indirect markers for the label-free distinction between both hormones. Tryptophan 195-205 insulin Homo sapiens 59-66 24167603-5 2013 High-resolution hyperspectral Raman imaging for these bands showed the distribution of disulfide bridges and tryptophan at sub-micrometer scale, which correlated with the location of insulin and glucagon as revealed by conventional immunohistochemistry. Tryptophan 109-119 insulin Homo sapiens 183-190 24167603-7 2013 Although the use of separate microscope systems with different spatial resolution and the use of indirect Raman markers cause some image mismatch, our findings indicate that Raman bands for disulfide bridges and tryptophan can be used as distinctive markers for the label-free detection of insulin and glucagon in human islets of Langerhans. Tryptophan 212-222 insulin Homo sapiens 290-297 22774401-1 2012 BACKGROUND: The aim of our study was to investigate the interaction of tryptophan-to-arginine (Trp64Arg) missense mutation in the beta3 adrenoreceptor (Beta3AR) with polymorphism in the UCP3 promotor (-55C->T) on insulin resistance in obese patients. Tryptophan 71-81 insulin Homo sapiens 216-223 12716660-8 2003 An insulin tolerance test was also used to determine whether weight loss altered the ability of insulin to modify plasma concentrations of tryptophan and of the other large neutral amino acids. Tryptophan 139-149 insulin Homo sapiens 96-103 16706200-1 2005 Using actin, alpha-lactalbumin and insulin as examples, it was shown that the formation of amorphous aggregates of proteins and amyloid fibrils leads to an increase in the rigidity of tryprophan and tyrosine residues micro-environment and, consequently, to the appearance of tryptophan (tyrosine) room temperature phosphorescence (RTP). Tryptophan 275-285 insulin Homo sapiens 35-42 12824951-9 2003 Patients with the Trp/Trp polymorphism in the b3-AR gene were characterized by higher glucose and insulin concentration during OGTT and higher blood concentration of FFA and TG during OLTT. Tryptophan 18-21 insulin Homo sapiens 98-105 12824951-9 2003 Patients with the Trp/Trp polymorphism in the b3-AR gene were characterized by higher glucose and insulin concentration during OGTT and higher blood concentration of FFA and TG during OLTT. Tryptophan 22-25 insulin Homo sapiens 98-105 11815479-0 2002 TRP genes: candidates for nonselective cation channels and store-operated channels in insulin-secreting cells. Tryptophan 0-3 insulin Homo sapiens 86-93 11323081-3 2001 A common primary event might be pancreatic insulin secretion for both insulin entry into the brain and 5-HT synthesis through variations in the ratio of tryptophan over competitor amino acids. Tryptophan 153-163 insulin Homo sapiens 43-50 11090300-3 2000 Evidence suggests that insulin activity plays a role in serotonergic activity by increasing the influx of tryptophan into the brain. Tryptophan 106-116 insulin Homo sapiens 23-30