PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 31142341-3 2019 The severity of HIE in infants is tightly associated with increased IL-1beta expression and astrocyte activation which was regulated by transient receptor potential vanilloid 1 (TRPV1), a non-selective cation channel in the TRP family. Tryptophan 178-181 interleukin 1 beta Homo sapiens 68-76 3289586-4 1988 Using the E. coli tryptophan promoter control of transcription, a 2.2 g/l production level of IL-1 beta was achieved in E. coli B at cell densities of 55 g dry weight per litre. Tryptophan 18-28 interleukin 1 beta Homo sapiens 94-103 30595799-0 2018 Tryptophan Photoproduct FICZ Upregulates IL1A, IL1B, and IL6 Expression via Oxidative Stress in Keratinocytes. Tryptophan 0-10 interleukin 1 beta Homo sapiens 47-51 28595944-5 2018 CMI cytokines, including IFN-gamma, TNFalpha and IL-1beta, induce the catabolism of tryptophan (TRY) by stimulating indoleamine 2,3-dioxygenase (IDO) resulting in the synthesis of kynurenine (KYN) and other tryptophan catabolites (TRYCATs). Tryptophan 84-94 interleukin 1 beta Homo sapiens 49-57 28595944-5 2018 CMI cytokines, including IFN-gamma, TNFalpha and IL-1beta, induce the catabolism of tryptophan (TRY) by stimulating indoleamine 2,3-dioxygenase (IDO) resulting in the synthesis of kynurenine (KYN) and other tryptophan catabolites (TRYCATs). Tryptophan 207-217 interleukin 1 beta Homo sapiens 49-57 17030574-1 2006 Gamma interferon (IFN-gamma)-induced indoleamine dioxygenase (IDO), which inhibits chlamydial replication by reducing the availability of tryptophan, is up-regulated by interleukin-1beta (IL-1beta) and tumor necrosis factor alpha (TNF-alpha). Tryptophan 138-148 interleukin 1 beta Homo sapiens 169-186 24974860-0 2014 IL-1beta increases expression of tryptophan 2,3-dioxygenase and stimulates tryptophan catabolism in endometrioma stromal cells. Tryptophan 33-43 interleukin 1 beta Homo sapiens 0-8 24974860-3 2014 We studied whether interleukin-1beta (IL-1beta), a typical endometriosis-associated cytokine, affects the expression of TDO and the catabolism of tryptophan in endometrioma stromal cells (ESCs). Tryptophan 146-156 interleukin 1 beta Homo sapiens 19-36 24974860-3 2014 We studied whether interleukin-1beta (IL-1beta), a typical endometriosis-associated cytokine, affects the expression of TDO and the catabolism of tryptophan in endometrioma stromal cells (ESCs). Tryptophan 146-156 interleukin 1 beta Homo sapiens 38-46 24974860-15 2014 CONCLUSION: IL-1beta is suggested to stimulate tryptophan catabolism and production of IL-6 and IL-8 by increasing TDO expression in endometriosis. Tryptophan 47-57 interleukin 1 beta Homo sapiens 12-20 26545369-5 2015 Pearson"s r correlation showed significance between the IL-1beta and both the CES-D score (r = 0.740, p < 0.01) and the KYN/TRP (kynurenine/tryptophan) ratio (r = 0.536, p = 0.02). Tryptophan 130-133 interleukin 1 beta Homo sapiens 57-65 26545369-5 2015 Pearson"s r correlation showed significance between the IL-1beta and both the CES-D score (r = 0.740, p < 0.01) and the KYN/TRP (kynurenine/tryptophan) ratio (r = 0.536, p = 0.02). Tryptophan 146-156 interleukin 1 beta Homo sapiens 57-65 26545369-7 2015 Mediation analysis showed that the relationship between the KYN/TRP ratio and the CES-D score was mediated by the IL-1beta. Tryptophan 65-68 interleukin 1 beta Homo sapiens 117-125 22071871-5 2012 Moreover, treatment with IL-1beta resulted in an increase in kynurenine, the catabolic product of IDO-induced tryptophan metabolism. Tryptophan 110-120 interleukin 1 beta Homo sapiens 25-33 22071871-7 2012 These observations indicate that IL-1beta has a critical role in regulating neurogenesis whereas affecting the availability of tryptophan and the production of enzymes conducive to toxic metabolites. Tryptophan 127-137 interleukin 1 beta Homo sapiens 33-41 19428234-10 2010 Moreover, tryptophan reduced the expression of the pro-inflammatory cytokines tumor necrosis factor-alpha, interleukin (IL)-6, interferon (IFN)-gamma, IL-12p40, IL-1beta and IL-17, as well as IL-8 and intracellular adhesion molecule-1, and resulted in increased expression of apoptosis initiators caspase-8 and Bax. Tryptophan 10-20 interleukin 1 beta Homo sapiens 161-169 17030574-1 2006 Gamma interferon (IFN-gamma)-induced indoleamine dioxygenase (IDO), which inhibits chlamydial replication by reducing the availability of tryptophan, is up-regulated by interleukin-1beta (IL-1beta) and tumor necrosis factor alpha (TNF-alpha). Tryptophan 138-148 interleukin 1 beta Homo sapiens 188-196 23345738-1 2001 Kinetic data measured from folding of the protein interleukin-1beta fits best to three exponential phases when studied with tryptophan fluorescence but only two exponential phases when measured using other methods. Tryptophan 124-134 interleukin 1 beta Homo sapiens 50-67 12466036-10 2002 Pro-inflammatory cytokines such as IL-1beta, IFN-alpha, IFN-gamma and TNF-alpha affect the 5-HT metabolism directly and/or indirectly by stimulating the enzyme indoleamine 2,3-dioxygenase which leads to a peripheral depletion of tryptophan. Tryptophan 229-239 interleukin 1 beta Homo sapiens 35-43 23345738-5 2001 Protein concentration-dependent folding studies demonstrate that, at lower interleukin-1beta concentrations, tryptophan fluorescence kinetics can be fit adequately with a two exponential fit. Tryptophan 109-119 interleukin 1 beta Homo sapiens 75-92 7615820-6 1995 Reducing the concentration of tryptophan from 25 microM to 0 markedly diminished the ability of fibroblasts to increase collagenase and stromelysin mRNA and collagenase production in response to IL-1 beta. Tryptophan 30-40 interleukin 1 beta Homo sapiens 195-204 7615820-7 1995 Addition of exogenous tryptophan (25-50 micrograms/ml) to cultures that had been tryptophan depleted by pretreatment with IFN-gamma for 48 h restored the fibroblast response to IL-1 beta or PMA, but had no effect on IFN-gamma-induced HLA-DR alpha chain mRNA expression. Tryptophan 22-32 interleukin 1 beta Homo sapiens 177-186 2817905-6 1989 Taken together with the results of steady-state measurements, we suggest that the single tryptophan of IL-1 beta is statically quenched by neighboring charged residues, whereas the tryptophan fluorescence of IL-1 alpha is unaffected by ionic strength, and that the tryptophans of the two proteins have different accessibilities to ionic quenchers. Tryptophan 89-99 interleukin 1 beta Homo sapiens 103-112 2817905-6 1989 Taken together with the results of steady-state measurements, we suggest that the single tryptophan of IL-1 beta is statically quenched by neighboring charged residues, whereas the tryptophan fluorescence of IL-1 alpha is unaffected by ionic strength, and that the tryptophans of the two proteins have different accessibilities to ionic quenchers. Tryptophan 265-276 interleukin 1 beta Homo sapiens 103-112