PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 28551532-11 2017 Kynurenine (50-100muM) and tryptophan (50-100muM) decreased while tryptophan (5muM) and kynurenic acid (100muM) increased the release of IL-6. Tryptophan 66-76 interleukin 6 Homo sapiens 137-141 28625979-3 2017 We found that ISX-mediated IL6-induced expression of the tryptophan catabolic enzymes Indoleamine 2,3-dioxygenase 1 (IDO1) and tryptophan 2,3-dioxygenase in hepatocellular carcinoma cells, resulting in an ISX-dependent increase in the tryptophan catabolite kynurenine and its receptor aryl hydrocarbon receptor (AHR). Tryptophan 57-67 interleukin 6 Homo sapiens 27-30 28625979-3 2017 We found that ISX-mediated IL6-induced expression of the tryptophan catabolic enzymes Indoleamine 2,3-dioxygenase 1 (IDO1) and tryptophan 2,3-dioxygenase in hepatocellular carcinoma cells, resulting in an ISX-dependent increase in the tryptophan catabolite kynurenine and its receptor aryl hydrocarbon receptor (AHR). Tryptophan 127-137 interleukin 6 Homo sapiens 27-30 18079991-7 2006 Increases of tryptophan and 5-HT, but not NE, are also elicited by IL-6, which also activates the HPA axis, although it is much less potent in these respects than IL-1. Tryptophan 13-23 interleukin 6 Homo sapiens 67-71 28724796-4 2017 Host IL-6 was identified as a pivotal cytokine mediator, as was host indoleamine 2,3-dioxygenase (IDO-1), which was upregulated in GVHD in an IL-6-dependent manner in microglial cells and was accompanied by dysregulated tryptophan metabolism in the dorsal raphe nucleus and prefrontal cortex. Tryptophan 220-230 interleukin 6 Homo sapiens 142-146 27272805-6 2016 C-reactive protein (CRP) and interleukin-6 (IL-6) correlated with each other and exhibited positive correlation with age, body-mass index (BMI), leukocyte count, platelet count, kynurenine, kynurenine/tryptophan ratio and urinary neopterin and a negative correlation with vitamin D and retinol. Tryptophan 201-211 interleukin 6 Homo sapiens 29-42 27272805-6 2016 C-reactive protein (CRP) and interleukin-6 (IL-6) correlated with each other and exhibited positive correlation with age, body-mass index (BMI), leukocyte count, platelet count, kynurenine, kynurenine/tryptophan ratio and urinary neopterin and a negative correlation with vitamin D and retinol. Tryptophan 201-211 interleukin 6 Homo sapiens 44-48 20822828-5 2011 Kyn/trp correlated strongly with concentrations of cytokine IL-6, of soluble interleukin-2 receptor-alpha and 75 kDa TNF-alpha receptor and of the macrophage marker neopterin (all p<0.001 or p<0.01) but not with TNF-alpha. Tryptophan 4-7 interleukin 6 Homo sapiens 60-64 28013248-9 2017 The association between tryptophan oxidation and CNS inflammatory responses as measured by CSF interleukin 6 (IL-6) concentration supports a role of kynurenine metabolites in the inflammatory pathogenesis of late-stage HAT. Tryptophan 24-34 interleukin 6 Homo sapiens 110-114 26641976-12 2016 Tryptophan showed a moderate degree of anti-inflammatory activity against TNF-alpha and IL-6. Tryptophan 0-10 interleukin 6 Homo sapiens 88-92 25616404-8 2015 The Kyn/Trp ratio was positively associated with CD8(+) T-cell activation and levels of inflammatory cytokines (interleukin 6, interferon gamma-inducible protein 10, interleukin 18, and tumor necrosis factor alpha) and negatively associated with dendritic cell frequencies at baseline and in untreated patients. Tryptophan 8-11 interleukin 6 Homo sapiens 112-164 25455350-9 2015 In patients, we also observed a positive correlation between IL-6 and the tryptophan:KYNA ratio, indicating that IL-6 activates the KYN pathway. Tryptophan 74-84 interleukin 6 Homo sapiens 61-65 25455350-9 2015 In patients, we also observed a positive correlation between IL-6 and the tryptophan:KYNA ratio, indicating that IL-6 activates the KYN pathway. Tryptophan 74-84 interleukin 6 Homo sapiens 113-117 24622832-11 2014 Statistically significantly lower levels of IL-1, IL-6 and TNF-alpha were observed in patients receiving melatonin and tryptophan, comparing with group III treated with Essentiale forte only. Tryptophan 119-129 interleukin 6 Homo sapiens 50-54 24553013-9 2013 Second, the more systemic regulation of tryptophan availability occurs via the IL-6 induction of IDO. Tryptophan 40-50 interleukin 6 Homo sapiens 79-83 19428234-10 2010 Moreover, tryptophan reduced the expression of the pro-inflammatory cytokines tumor necrosis factor-alpha, interleukin (IL)-6, interferon (IFN)-gamma, IL-12p40, IL-1beta and IL-17, as well as IL-8 and intracellular adhesion molecule-1, and resulted in increased expression of apoptosis initiators caspase-8 and Bax. Tryptophan 10-20 interleukin 6 Homo sapiens 107-125 22084588-8 2010 KYN/TRP correlated with neopterin (p < 0.001) and also with TNF-alpha (p < 0.01) and IL-6 concentrations (p < 0.05) and inversely with the in vitro response of stimulated monocytes. Tryptophan 4-7 interleukin 6 Homo sapiens 91-95 9692957-2 1998 The fluorescence from Trp157, the single tryptophan residue in the primary sequence of IL-6, is altered in IL-6D, where the wavelength maximum is blue-shifted by 3 nm and the emission intensity is reduced by 30%. Tryptophan 41-51 interleukin 6 Homo sapiens 87-91 11459382-8 2001 The changes in the tryptophan/CAA ratio from the end of term to the early puerperium were significantly and inversely related to serum IL-6, IL-IRA and LIF-R. Tryptophan 19-29 interleukin 6 Homo sapiens 135-139 15206740-9 2003 These data demonstrate an altered TRP metabolism in a subgroup of FM patients, where the TD seems to activate 5-HT metabolism and IL-6 production. Tryptophan 34-37 interleukin 6 Homo sapiens 130-134 12471139-6 2002 Depletion of tryptophan led to stabilization of IL-6 and IL-8 mRNA and increased IL-6 and IL-8 responses, whereas supplementing tryptophan largely restored these changes. Tryptophan 13-23 interleukin 6 Homo sapiens 48-52 12471139-6 2002 Depletion of tryptophan led to stabilization of IL-6 and IL-8 mRNA and increased IL-6 and IL-8 responses, whereas supplementing tryptophan largely restored these changes. Tryptophan 13-23 interleukin 6 Homo sapiens 81-85 9825023-6 1998 The results suggest that: 1) in normal humans, the availability of plasma tryptophan to the brain decreases with age, and with activation of the immune system; and 2) increased production of IL-6 may play a role in the pathogenesis of DAT. Tryptophan 74-84 interleukin 6 Homo sapiens 191-195 1872826-0 1991 Effect of synthesized constituents in the L-tryptophan product on the differentiation of eosinophils and the induction of IL-6: a possible cause of eosinophilia-myalgia syndrome. Tryptophan 42-54 interleukin 6 Homo sapiens 122-126 9657419-3 1998 There were significant correlations between the availability of tryptophan to the brain and serum IL-6, IL-8 and IL-1RA (all negative) and CC16 (positive). Tryptophan 64-74 interleukin 6 Homo sapiens 98-102 7908745-5 1993 There were significant correlations between plasma L-TRP levels, on the one hand, and Tf plasma levels, DPP IV activity (both positive), Il-6 production, and Hp plasma levels (both negative), on the other. Tryptophan 51-56 interleukin 6 Homo sapiens 137-141 7908745-6 1993 Up to 63.7% of the variance in L-TRP plasma concentrations could be explained by DPP IV, Hp, Il-6 values, and gender. Tryptophan 31-36 interleukin 6 Homo sapiens 93-97 9629951-7 1998 There were significant and inverse relationships between the availability of plasma tryptophan and serum IL-1RA, IL-6 and IL-8. Tryptophan 84-94 interleukin 6 Homo sapiens 113-117 35396024-5 2022 Elevated proinflammatory cytokines (specifically, interleukin-6) in CSF imply the role of neuroinflammation resulting in activation of the tryptophan-kynurenine pathway. Tryptophan 139-149 interleukin 6 Homo sapiens 50-63 2268669-2 1990 The homonuclear Hartmann-Hahn spectrum clearly shows all connectivities for the histidine, tyrosine and tryptophan residues that exist in IL-6. Tryptophan 104-114 interleukin 6 Homo sapiens 138-142 34902346-9 2022 Kynurenine and the KYN/TRP ratio significantly correlated with IL-6 (rho = 0.441 and 0.448, p-values < 0.001). Tryptophan 23-26 interleukin 6 Homo sapiens 63-67 35493463-8 2022 TRP score was positively associated with malignant pathways in pan-cancer, such as IL6-JAK-STAT3 signalling, interferon-gamma response, and inflammatory response. Tryptophan 0-3 interleukin 6 Homo sapiens 83-86 33622713-2 2021 The tryptophan catabolizing enzyme IDO1 (indoleamine 2,3-dioxygenase) has been implicated in promoting neovascularization through its positioning as a key regulatory node between the inflammatory cytokines IFNgamma and IL6. Tryptophan 4-14 interleukin 6 Homo sapiens 219-222 4084549-5 1985 Of special interest, tyrosine A, phenylalanine A, tryptophan B1, and tryptophan B2 were found to be located close to a cluster of aliphatic residues, indicating that the hydrophobic site of the HSF is conformationally rigid and its tertiary structure very compact. Tryptophan 50-60 interleukin 6 Homo sapiens 194-197 32559180-2 2020 Indeed, these changes in tryptophan metabolism correlated with interleukin-6 (IL-6) levels. Tryptophan 25-35 interleukin 6 Homo sapiens 63-76 33616466-7 2021 TRP (10 muM) enhanced the production of IL-6 by the corneal epithelium and had no effect on IL-1beta and IL-10. Tryptophan 0-3 interleukin 6 Homo sapiens 40-44 33312105-0 2020 Interleukin-6 is associated with tryptophan metabolism and signs of depression in individuals with carbohydrate malabsorption. Tryptophan 33-43 interleukin 6 Homo sapiens 0-13 33312105-4 2020 Serum IL-6 levels were positively correlated with the BDI score (p = 0.001, rho = 0.205) and indicators of TRP metabolism (KYN/TRP ratio, KYN) (P-values < 0.05, rho = 0.176 and 0.136). Tryptophan 107-110 interleukin 6 Homo sapiens 6-10 33312105-4 2020 Serum IL-6 levels were positively correlated with the BDI score (p = 0.001, rho = 0.205) and indicators of TRP metabolism (KYN/TRP ratio, KYN) (P-values < 0.05, rho = 0.176 and 0.136). Tryptophan 127-130 interleukin 6 Homo sapiens 6-10 33312105-7 2020 IL-6 and LBP were associated with indicators of TRP metabolism. Tryptophan 48-51 interleukin 6 Homo sapiens 0-4 32531426-8 2020 Furthermore, prenatal Trp levels and the Kyn/Trp ratio moderate the association between IL-6 levels and depressive symptoms during the perinatal and the post-partum period. Tryptophan 22-25 interleukin 6 Homo sapiens 88-92 32531426-8 2020 Furthermore, prenatal Trp levels and the Kyn/Trp ratio moderate the association between IL-6 levels and depressive symptoms during the perinatal and the post-partum period. Tryptophan 45-48 interleukin 6 Homo sapiens 88-92 32559180-2 2020 Indeed, these changes in tryptophan metabolism correlated with interleukin-6 (IL-6) levels. Tryptophan 25-35 interleukin 6 Homo sapiens 78-82 30335249-1 2018 Quinolinic acid activates NMDA receptors in the central nervous system and stimulates the secretion of interleukins IL-6 and 1L-1beta, among others, promoting hyper-activity of the HPA axis and reinforcing a bias of the tryptophan metabolism to produce quinolinic acid, and interleukins by the innate immune system, further reducing the synthesis of serotonin and consolidating the depressive process.We discuss the evidence showing that this process can be initiated by either interleukin stimulated by an infection or some vaccines or excessive psychological stress that activates the HPA axis together with said innate immune response, causing a process of aseptic inflammation in the central nervous system. Tryptophan 220-230 interleukin 6 Homo sapiens 116-133 32511571-6 2020 Indeed, the observed changes in tryptophan metabolism correlated with serum interleukin-6 (IL-6) levels. Tryptophan 32-42 interleukin 6 Homo sapiens 76-89 32511571-6 2020 Indeed, the observed changes in tryptophan metabolism correlated with serum interleukin-6 (IL-6) levels. Tryptophan 32-42 interleukin 6 Homo sapiens 91-95 31923274-6 2020 Markers of tryptophan degradation by the kynurenine pathway (kynurenine/tryptophan ratio) and activation of vitamin B6 catabolism (pyridoxic acid/(pyridoxal + pyridoxal 5"-phosphate), PAr index) differed in survivors with or without CF and correlated with known markers of immune activation and inflammation, such as neopterin, C-reactive protein and Interleukin-6. Tryptophan 11-21 interleukin 6 Homo sapiens 351-364 32139353-12 2020 RESULTS: The KYN/TRP ratio correlated positively with IL-6 and CD56bright NK-cells and negatively with CD56dim NKcells. Tryptophan 17-20 interleukin 6 Homo sapiens 54-58 31355138-10 2019 At the gene level, miR-153 targeted IDO1 expression and inhibited bladder cancer cell tryptophan metabolism through inhibiting IL6/STAT3/VEGF signaling. Tryptophan 86-96 interleukin 6 Homo sapiens 127-130 30595799-0 2018 Tryptophan Photoproduct FICZ Upregulates IL1A, IL1B, and IL6 Expression via Oxidative Stress in Keratinocytes. Tryptophan 0-10 interleukin 6 Homo sapiens 57-60