PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 29232843-1 2017 The decapeptide gonadotropin-releasing hormone, also referred to as luteinizing hormone-releasing hormone with the sequence (pGlu-His-Trp-Ser-Tyr-Gly-Leu-Arg-Pro-Gly-NH2) plays an important role in regulating the reproductive system. Tryptophan 134-137 gonadotropin releasing hormone 1 Homo sapiens 16-46 25404067-1 2014 Using the chain-build-up method based on Empirical Conformational Energies of Peptides Program including solvation, we have computed, the low energy conformations of gonadotrpin-releasing hormone, GnRH, whose sequence is Pyro-Glu(PG)-His-Trp-Ser-Tyr-Gly-Leu-Arg-Pro-Gly-NH2. Tryptophan 238-241 gonadotropin releasing hormone 1 Homo sapiens 197-201 25583361-6 2015 [2-Nal(3)]-GnRH retained high affinity at receptors with non-polar His(7.36(305)) substitutions, supporting a role for His(7.36(305)) in recognizing Trp(3) of GnRH. Tryptophan 149-152 gonadotropin releasing hormone 1 Homo sapiens 11-15 25583361-8 2015 Results suggest that His(7.36(305)) of the GnRH receptor forms two distinct interactions that determine binding to Trp(3) and couple agonist binding to the conserved transmembrane domain network that activates GPCRs. Tryptophan 115-118 gonadotropin releasing hormone 1 Homo sapiens 43-47 23016589-1 2013 Lamprey gonadotropin-releasing hormone-III (lGnRH-III; Glp-His-Trp-Ser-His-Asp-Trp-Lys-Pro-Gly-NH2), a native isoform of human GnRH (GnRH-I), was initially isolated from the brain of the sea lamprey (Petromyzon marinus). Tryptophan 79-82 gonadotropin releasing hormone 1 Homo sapiens 45-51 15544487-1 2004 Gonadotropin-releasing hormone (GnRH) or luteinizing hormone-releasing hormone (LHRH) is a decapeptide (pGlu-His-Trp-Ser-Tyr-Gly-Leu-Arg-Pro-Gly-NH2) hypothalamic hormone that acts upon 7-trans membrane spanning GnRH receptors in the pituitary. Tryptophan 113-116 gonadotropin releasing hormone 1 Homo sapiens 0-30 18927217-3 2009 We found that its amino acid sequence (pGlu-His-Trp-Ser-Tyr-Gly-Leu-Arg-Pro-Gly-NH(2)) was identical to that of mammalian GnRH. Tryptophan 48-51 gonadotropin releasing hormone 1 Homo sapiens 122-126 15967801-1 2005 The human gonadotropin-releasing hormone (GnRH) receptor is evolutionarily configured for high affinity binding of GnRH I ([Tyr(5),Leu(7),Arg(8)]GnRH) but at lower affinity for GnRH II ([His(5),Trp(7),Tyr(8)]GnRH). Tryptophan 194-197 gonadotropin releasing hormone 1 Homo sapiens 42-46 15967801-1 2005 The human gonadotropin-releasing hormone (GnRH) receptor is evolutionarily configured for high affinity binding of GnRH I ([Tyr(5),Leu(7),Arg(8)]GnRH) but at lower affinity for GnRH II ([His(5),Trp(7),Tyr(8)]GnRH). Tryptophan 194-197 gonadotropin releasing hormone 1 Homo sapiens 115-119 15967801-1 2005 The human gonadotropin-releasing hormone (GnRH) receptor is evolutionarily configured for high affinity binding of GnRH I ([Tyr(5),Leu(7),Arg(8)]GnRH) but at lower affinity for GnRH II ([His(5),Trp(7),Tyr(8)]GnRH). Tryptophan 194-197 gonadotropin releasing hormone 1 Homo sapiens 115-119 15544487-1 2004 Gonadotropin-releasing hormone (GnRH) or luteinizing hormone-releasing hormone (LHRH) is a decapeptide (pGlu-His-Trp-Ser-Tyr-Gly-Leu-Arg-Pro-Gly-NH2) hypothalamic hormone that acts upon 7-trans membrane spanning GnRH receptors in the pituitary. Tryptophan 113-116 gonadotropin releasing hormone 1 Homo sapiens 32-36 15544487-1 2004 Gonadotropin-releasing hormone (GnRH) or luteinizing hormone-releasing hormone (LHRH) is a decapeptide (pGlu-His-Trp-Ser-Tyr-Gly-Leu-Arg-Pro-Gly-NH2) hypothalamic hormone that acts upon 7-trans membrane spanning GnRH receptors in the pituitary. Tryptophan 113-116 gonadotropin releasing hormone 1 Homo sapiens 212-216 8906302-0 1996 Variations of free and total tryptophan serum levels after GN-RH administration in patients with amenhorrea. Tryptophan 29-39 gonadotropin releasing hormone 1 Homo sapiens 59-64 10684817-1 2000 In the brain of all vertebrate classes, chicken (c) GnRH-II ([His(5), Trp(7),Tyr(8)]GnRH, cGnRH-II) is expressed in the mesencephalon. Tryptophan 70-73 gonadotropin releasing hormone 1 Homo sapiens 52-56 11255560-1 2000 Gonadotropin-releasing hormone (GnRH) is a decapeptide (pGlu-His-Trp-Ser-Tyr-Gly-Leu-Arg-Pro-Gly.NH2) which is produced from a precursor polypeptide in hypothalamic neurons and secreted in a pulsatile fashion to stimulate the secretion of LH and FSH via its interaction with a cognate receptor on gonadotropes. Tryptophan 65-68 gonadotropin releasing hormone 1 Homo sapiens 0-30 11255560-1 2000 Gonadotropin-releasing hormone (GnRH) is a decapeptide (pGlu-His-Trp-Ser-Tyr-Gly-Leu-Arg-Pro-Gly.NH2) which is produced from a precursor polypeptide in hypothalamic neurons and secreted in a pulsatile fashion to stimulate the secretion of LH and FSH via its interaction with a cognate receptor on gonadotropes. Tryptophan 65-68 gonadotropin releasing hormone 1 Homo sapiens 32-36 8816823-5 1996 Tunicate GnRH-I (pGlu-His-Trp-Ser-Asp-Tyr-Phe-Lys-Pro-Gly-NH2) has 60% of its residues conserved, compared with mammalian GnRH, whereas tunicate GnRH-II (pGlu-His-Trp-Ser-Leu-Cys-His-Ala-Pro-Gly-NH2) is unusual in that it was isolated as a disulfide-linked dimer. Tryptophan 26-29 gonadotropin releasing hormone 1 Homo sapiens 9-13 8816823-5 1996 Tunicate GnRH-I (pGlu-His-Trp-Ser-Asp-Tyr-Phe-Lys-Pro-Gly-NH2) has 60% of its residues conserved, compared with mammalian GnRH, whereas tunicate GnRH-II (pGlu-His-Trp-Ser-Leu-Cys-His-Ala-Pro-Gly-NH2) is unusual in that it was isolated as a disulfide-linked dimer. Tryptophan 163-166 gonadotropin releasing hormone 1 Homo sapiens 9-13 6394691-6 1984 Amino acid composition and sequence analyses confirmed the structure of this form of chicken LHRH as pGlu-His-Trp-Ser-Tyr-Gly-Leu-Gln-Pro-Gly-NH2. Tryptophan 110-113 gonadotropin releasing hormone 1 Homo sapiens 93-97 7761629-7 1995 The amino acid sequence of sturgeon GnRH is pGlu-His-Trp-Ser-Tyr-Gly-Leu-Arg-Pro-Gly-NH2. Tryptophan 53-56 gonadotropin releasing hormone 1 Homo sapiens 36-40 2556391-2 1989 Variant forms of mammalian gonadotropin-releasing hormone (GnRH) (pGlu-His-Trp-Ser-Tyr-Gly-Leu-Arg-Pro-Gly.NH2) are present in chicken ([Gln8] GnRH and [His5, Trp7, Tyr8]GnRH), salmon ([Trp7, Leu8]GnRH), and lamprey ([Tyr3, Leu5, Glu6, Trp7, Lys8] GnRH). Tryptophan 75-78 gonadotropin releasing hormone 1 Homo sapiens 27-57 2556391-2 1989 Variant forms of mammalian gonadotropin-releasing hormone (GnRH) (pGlu-His-Trp-Ser-Tyr-Gly-Leu-Arg-Pro-Gly.NH2) are present in chicken ([Gln8] GnRH and [His5, Trp7, Tyr8]GnRH), salmon ([Trp7, Leu8]GnRH), and lamprey ([Tyr3, Leu5, Glu6, Trp7, Lys8] GnRH). Tryptophan 75-78 gonadotropin releasing hormone 1 Homo sapiens 59-63 2556391-2 1989 Variant forms of mammalian gonadotropin-releasing hormone (GnRH) (pGlu-His-Trp-Ser-Tyr-Gly-Leu-Arg-Pro-Gly.NH2) are present in chicken ([Gln8] GnRH and [His5, Trp7, Tyr8]GnRH), salmon ([Trp7, Leu8]GnRH), and lamprey ([Tyr3, Leu5, Glu6, Trp7, Lys8] GnRH). Tryptophan 75-78 gonadotropin releasing hormone 1 Homo sapiens 143-147 2556391-2 1989 Variant forms of mammalian gonadotropin-releasing hormone (GnRH) (pGlu-His-Trp-Ser-Tyr-Gly-Leu-Arg-Pro-Gly.NH2) are present in chicken ([Gln8] GnRH and [His5, Trp7, Tyr8]GnRH), salmon ([Trp7, Leu8]GnRH), and lamprey ([Tyr3, Leu5, Glu6, Trp7, Lys8] GnRH). Tryptophan 75-78 gonadotropin releasing hormone 1 Homo sapiens 143-147 2556391-2 1989 Variant forms of mammalian gonadotropin-releasing hormone (GnRH) (pGlu-His-Trp-Ser-Tyr-Gly-Leu-Arg-Pro-Gly.NH2) are present in chicken ([Gln8] GnRH and [His5, Trp7, Tyr8]GnRH), salmon ([Trp7, Leu8]GnRH), and lamprey ([Tyr3, Leu5, Glu6, Trp7, Lys8] GnRH). Tryptophan 75-78 gonadotropin releasing hormone 1 Homo sapiens 143-147 2556391-2 1989 Variant forms of mammalian gonadotropin-releasing hormone (GnRH) (pGlu-His-Trp-Ser-Tyr-Gly-Leu-Arg-Pro-Gly.NH2) are present in chicken ([Gln8] GnRH and [His5, Trp7, Tyr8]GnRH), salmon ([Trp7, Leu8]GnRH), and lamprey ([Tyr3, Leu5, Glu6, Trp7, Lys8] GnRH). Tryptophan 75-78 gonadotropin releasing hormone 1 Homo sapiens 143-147 2681686-1 1989 Endopeptidase (EP) 24.15 cleaves the Tyr5-Gly6 bond of luteinizing hormone-releasing hormone (LHRH) (pGlu-His-Trp-Ser-Tyr-Gly-Leu-Arg-Pro-Gly-NH2), and is the primary LHRH degrading enzyme in pituitary and hypothalamic membrane preparations. Tryptophan 110-113 gonadotropin releasing hormone 1 Homo sapiens 55-92 2681686-1 1989 Endopeptidase (EP) 24.15 cleaves the Tyr5-Gly6 bond of luteinizing hormone-releasing hormone (LHRH) (pGlu-His-Trp-Ser-Tyr-Gly-Leu-Arg-Pro-Gly-NH2), and is the primary LHRH degrading enzyme in pituitary and hypothalamic membrane preparations. Tryptophan 110-113 gonadotropin releasing hormone 1 Homo sapiens 94-98 2681686-1 1989 Endopeptidase (EP) 24.15 cleaves the Tyr5-Gly6 bond of luteinizing hormone-releasing hormone (LHRH) (pGlu-His-Trp-Ser-Tyr-Gly-Leu-Arg-Pro-Gly-NH2), and is the primary LHRH degrading enzyme in pituitary and hypothalamic membrane preparations. Tryptophan 110-113 gonadotropin releasing hormone 1 Homo sapiens 167-171 2689597-3 1989 The nuclear magnetic resonance spectroscopy shows that the mode of coordination of Zn(II) to LHRH consists of binding to the imidazole nitrogen and the peptide oxygen of the His-Trp bond. Tryptophan 178-181 gonadotropin releasing hormone 1 Homo sapiens 93-97 2968964-1 1988 (D-Trp)6-LHRH:pGlu-His-Trp-Ser-Tyr-D-Trp-Leu-Arg-Pro-GlyNH2 was prepared by solid-phase peptide synthesis using the nitro group to protect the guanidine side chain of the arginyl residue. Tryptophan 3-6 gonadotropin releasing hormone 1 Homo sapiens 9-13 3004562-5 1985 Tryptophan is another constituent that participates in the GnRH binding site, as pretreatment of pituitary membranes with 2-methoxy-5-nitrobenzyl bromide inhibited the binding (IC50 = 0.22 mM) by decreasing receptor affinity. Tryptophan 0-10 gonadotropin releasing hormone 1 Homo sapiens 59-63 2983326-4 1985 A major product was the NH2-terminal tripeptide, less than Glu-His-Trp, and another was LH-RH-(4-10) heptapeptide, indicating that the Trp-Ser bond is cleaved to release the NH2-terminal tripeptide. Tryptophan 135-138 gonadotropin releasing hormone 1 Homo sapiens 88-93 1091737-3 1975 Eleven analogs of LH-RH (SMALLER THAN Glu-His-Trp-Ser-Tyr-Gly-Leu-Arg-Pro-Gly-NH2) have been synthesized by the fragment condensation method and the repetitive excess mixed anhydride method. Tryptophan 46-49 gonadotropin releasing hormone 1 Homo sapiens 18-23 6203623-5 1984 Similar serotonin binding sites were found to exist on LHRH (Tyr Ser Trp) and MSH-ACTH tetrapeptide (Phe Arg Trp). Tryptophan 69-72 gonadotropin releasing hormone 1 Homo sapiens 55-59 383316-5 1979 With tryptophan substitution in position 6 (D-TRP6-LHRH), mean LH levels in five subjects were still above the normal range 24 h after a single intranasal dose. Tryptophan 5-15 gonadotropin releasing hormone 1 Homo sapiens 51-55 2282-1 1976 The conformation of the gonadotropin releasing hormone (Gn-RH), whose primary sequence is pGlu-His-Trp-Ser-Tyr-Gly-Leu-Arg-Pro-GlyNH2, and of several of its structural analogues has been studied by circular dichroism, optical rotatory dispersion, and fluorescence spectroscopy. Tryptophan 99-102 gonadotropin releasing hormone 1 Homo sapiens 24-54 2282-1 1976 The conformation of the gonadotropin releasing hormone (Gn-RH), whose primary sequence is pGlu-His-Trp-Ser-Tyr-Gly-Leu-Arg-Pro-GlyNH2, and of several of its structural analogues has been studied by circular dichroism, optical rotatory dispersion, and fluorescence spectroscopy. Tryptophan 99-102 gonadotropin releasing hormone 1 Homo sapiens 56-61 7050119-9 1982 These studies indicate that the structure of chicken hypothalamic LH-RH is: pGlu-His-Trp-Ser-Tyr-Gly-Leu-Gln-Pro-Gly-NH2. Tryptophan 85-88 gonadotropin releasing hormone 1 Homo sapiens 66-71 7041967-1 1982 The substrate specificity of a peptidase from anterior pituitaries that is capable of hydrolyzing luteinizing hormone-releasing hormone (LH-RH; less than Glu-His-Trp-Ser-Tyr-Gly-Leu-Arg-Pro-Gly-NH2) at the Tyr5-Gly6 peptide bond has been investigated by using inhibitors and model substrates. Tryptophan 162-165 gonadotropin releasing hormone 1 Homo sapiens 98-135 344245-1 1978 The decapeptide corresponding to the amino acid sequence of porcine luteinizing hormone-releasing hormone (LH-RH) which involves 1 mol of tryptophan was synthesized via solid phase synthesis with two different deblocking procedures which used hydrogen chloride in formic acid and hydrogen chloride in acetic acid containing 1% 2-mercaptoethanol. Tryptophan 138-148 gonadotropin releasing hormone 1 Homo sapiens 68-105 344245-1 1978 The decapeptide corresponding to the amino acid sequence of porcine luteinizing hormone-releasing hormone (LH-RH) which involves 1 mol of tryptophan was synthesized via solid phase synthesis with two different deblocking procedures which used hydrogen chloride in formic acid and hydrogen chloride in acetic acid containing 1% 2-mercaptoethanol. Tryptophan 138-148 gonadotropin releasing hormone 1 Homo sapiens 107-112