PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 32726040-5 2020 The results showed that the lower the concentration of chlorogenic acid, the higher the inhibition rate of Jun N-terminal kinase(JNK) at downstream of IL-1 by the combination of chlorogenic acid and linalool; the higher the concentration of luteolin in IL-6 pathway, the higher the inhibition rate of C-reactive protein(CRP) at downstream of IL-6 by the combination of chlorogenic acid and luteolin. linalool 199-207 interleukin 1 alpha Homo sapiens 151-155 32726040-6 2020 It revealed that the potential efficacy markers of Lonicerae Japonicae Flos in heat-clearing and detoxifying effect based on IL-1 signaling pathway were chlorogenic acid and linalool, and the potential efficacy markers of Lonicerae Japonicae Flos in heat-clearing and detoxifying effect based on IL-6 signaling pathway were chlorogenic acid and luteolin. linalool 174-182 interleukin 1 alpha Homo sapiens 125-129 33126443-8 2020 Linalool decreased TLR4, MYD88 and TRIF gene and protein expressions; diminished related inflammatory mediators such as TNF-alpha, IL-1beta, IL-6, and NF-kappaB; and down-regulated HMBG1. linalool 0-8 interleukin 1 alpha Homo sapiens 131-139