PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
22975888-10	2012	In P-glycoprotein-knockout mice, buprenorphine-related effects on VE (p < .01), TE (p < .001), and TI (p < .05) and norbuprenorphine-related effects on VE (p < .05) and TI (p < .001) were significantly enhanced.	Buprenorphine	33-46	ATP binding cassette subfamily B member 1	Homo sapiens	3-17	
23599513-0	2013	P-glycoprotein should be considered as an additional factor contributing to opioid-induced respiratory depression in paediatrics: the buprenorphine example.	Buprenorphine	134-147	ATP binding cassette subfamily B member 1	Homo sapiens	0-14	
22975888-0	2012	Respiratory toxicity of buprenorphine results from the blockage of P-glycoprotein-mediated efflux of norbuprenorphine at the blood-brain barrier in mice.	Buprenorphine	24-37	ATP binding cassette subfamily B member 1	Homo sapiens	67-81	
22975888-3	2012	Recently, norbuprenorphine, in contrast to buprenorphine, was shown in vitro to be a substrate of human P-glycoprotein, a drug-transporter involved in all steps of pharmacokinetics including transport at the blood-brain barrier.	Buprenorphine	13-26	ATP binding cassette subfamily B member 1	Homo sapiens	104-118	
22975888-4	2012	Our objectives were to assess P-glycoprotein involvement in norbuprenorphine transport in vivo and study its role in the modulation of buprenorphine-related respiratory effects in mice.	Buprenorphine	63-76	ATP binding cassette subfamily B member 1	Homo sapiens	30-44	
22975888-13	2012	CONCLUSIONS: P-glycoprotein plays a key-protective role in buprenorphine-related respiratory effects, by allowing norbuprenorphine efflux at the blood-brain barrier.	Buprenorphine	59-72	ATP binding cassette subfamily B member 1	Homo sapiens	13-27	
22975888-14	2012	Our findings suggest a major role for drug-drug interactions that lead to P-glycoprotein inhibition in buprenorphine-associated fatalities and respiratory depression.	Buprenorphine	103-116	ATP binding cassette subfamily B member 1	Homo sapiens	74-88	
19887017-2	2010	The limited data obtained using in-vitro models indicate that methadone, buprenorphine, and cannabinoids may interact with human P-gp; but almost nothing is known about drugs of abuse and BCRP.	Buprenorphine	73-86	ATP binding cassette subfamily B member 1	Homo sapiens	129-133	
22739506-6	2012	Human P-glycoprotein-mediated transport in vitro of buprenorphine, norbuprenorphine, and their respective glucuronide conjugates was assessed by using transfected cells.	Buprenorphine	52-65	ATP binding cassette subfamily B member 1	Homo sapiens	6-20	
19887017-5	2010	Human P-gp was significantly inhibited in a concentration-dependent manner by norbuprenorphine>buprenorphine>methadone>ibogaine and THC.	Buprenorphine	81-94	ATP binding cassette subfamily B member 1	Homo sapiens	6-10	
32585880-5	2020	Moreover, the drug-drug interaction (DDI) potential of buprenorphine with CYP3A4 and P-glycoprotein perpetrator drugs should be elucidated.	Buprenorphine	55-68	ATP binding cassette subfamily B member 1	Homo sapiens	85-99	
17001553-0	2006	Role of human placental efflux transporter P-glycoprotein in the transfer of buprenorphine, levo-alpha-acetylmethadol, and paclitaxel.	Buprenorphine	77-90	ATP binding cassette subfamily B member 1	Homo sapiens	43-57	
17001553-1	2006	This study examines the role of placental P-glycoprotein (P-gp) in the transfer of buprenorphine (BUP) and L-alpha-acetylmethadol (LAAM) across the dually perfused human placental lobule.	Buprenorphine	83-96	ATP binding cassette subfamily B member 1	Homo sapiens	42-56	
17001553-1	2006	This study examines the role of placental P-glycoprotein (P-gp) in the transfer of buprenorphine (BUP) and L-alpha-acetylmethadol (LAAM) across the dually perfused human placental lobule.	Buprenorphine	83-96	ATP binding cassette subfamily B member 1	Homo sapiens	58-62	
17001553-1	2006	This study examines the role of placental P-glycoprotein (P-gp) in the transfer of buprenorphine (BUP) and L-alpha-acetylmethadol (LAAM) across the dually perfused human placental lobule.	Buprenorphine	98-101	ATP binding cassette subfamily B member 1	Homo sapiens	42-56	
17001553-1	2006	This study examines the role of placental P-glycoprotein (P-gp) in the transfer of buprenorphine (BUP) and L-alpha-acetylmethadol (LAAM) across the dually perfused human placental lobule.	Buprenorphine	98-101	ATP binding cassette subfamily B member 1	Homo sapiens	58-62