PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
29197801-7	2018	The enhanced generation of reactive oxygen intermediates and nitric oxide by macrophages from mice treated with buprenorphine, oxycodone or morphine was also shown, along with increased release of IL-6, TNFalpha and TGFbeta.	Buprenorphine	112-125	interleukin 6	Mus musculus	197-201	
28572711-4	2017	Buprenorphine administration altered the expression of cytokines, IFN-gamma, IL-6, and MMP-3, and oxidative markers, for example, iNOS, superoxide dismutase (SOD1), and catalase (CAT), in the CIA mice.	Buprenorphine	0-13	interleukin 6	Mus musculus	77-81	
31486774-3	2019	However, emerging evidence suggest that a commonly recommended opioid, buprenorphine, dramatically elevated circulating IL-6 levels and reduced animal survival in male C57BL/6 mice, but not in female mice possibly due to the complex interference of estrous cycles, fueling an ongoing debate regarding the possible impact of analgesic administration on the sepsis-induced systemic inflammation.	Buprenorphine	71-84	interleukin 6	Mus musculus	120-124	
31486774-4	2019	As per the recommendation of a local government agency, we performed a pilot study and confirmed that repetitive administration of buprenorphine indeed markedly elevated circulating levels of four sepsis surrogate markers (e.g., IL-6, KC, MCP-1 and G-CSF) in 20- 60% of septic animals.	Buprenorphine	131-144	interleukin 6	Mus musculus	229-233