PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
12033517-3	2002	Buprenorphine strongly inhibited the CYP3A4- and CYP2D6-catalyzed reactions with Ki values of 14.7 microM and 21.4 microM, respectively.	Buprenorphine	0-13	cytochrome P450 family 2 subfamily D member 6	Homo sapiens	49-55	
15684471-2	2005	When buprenorphine (BN), a potent mixed agonist-antagonist analgesic, was evaluated by this method, it exhibited potent inhibition of CYP2D6 with an IC50 value of 0.25 microM in recombinant CYP2D6-expressing insect cell microsomes (rCYP2D6 microsomes).	Buprenorphine	5-18	cytochrome P450 family 2 subfamily D member 6	Homo sapiens	134-140	
22369095-8	2012	AIMS: To compare the O- (CYP2D6 mediated) and N- (CYP3A4 mediated) demethylation metabolism of tramadol between methadone and buprenorphine maintained CYP2D6 extensive metabolizer subjects.	Buprenorphine	126-139	cytochrome P450 family 2 subfamily D member 6	Homo sapiens	151-157	
15684471-2	2005	When buprenorphine (BN), a potent mixed agonist-antagonist analgesic, was evaluated by this method, it exhibited potent inhibition of CYP2D6 with an IC50 value of 0.25 microM in recombinant CYP2D6-expressing insect cell microsomes (rCYP2D6 microsomes).	Buprenorphine	5-18	cytochrome P450 family 2 subfamily D member 6	Homo sapiens	190-196	
15684471-2	2005	When buprenorphine (BN), a potent mixed agonist-antagonist analgesic, was evaluated by this method, it exhibited potent inhibition of CYP2D6 with an IC50 value of 0.25 microM in recombinant CYP2D6-expressing insect cell microsomes (rCYP2D6 microsomes).	Buprenorphine	20-22	cytochrome P450 family 2 subfamily D member 6	Homo sapiens	134-140	
15684471-2	2005	When buprenorphine (BN), a potent mixed agonist-antagonist analgesic, was evaluated by this method, it exhibited potent inhibition of CYP2D6 with an IC50 value of 0.25 microM in recombinant CYP2D6-expressing insect cell microsomes (rCYP2D6 microsomes).	Buprenorphine	20-22	cytochrome P450 family 2 subfamily D member 6	Homo sapiens	190-196	
12756210-4	2003	Buprenorphine exhibited potent, competitive inhibition of CYP2D6 (Ki 10 +/- 2 microM and 1.8 +/- 0.2 microM) and CYP3A4 (Ki 40 +/- 1.6 microM and 19 +/- 1.2 microM) in microsomes from human liver and cDNA-expressing lymphoblasts, respectively.	Buprenorphine	0-13	cytochrome P450 family 2 subfamily D member 6	Homo sapiens	58-64	
12756210-6	2003	Furthermore, buprenorphine was shown to be a substrate of CYP2D6 (Km = 600 microM; Vmax = 0.40 nmol/min/mg protein) and CYP3A4 (Km = 36 microM; Vmax = 0.19 nmol/min/mg protein).	Buprenorphine	13-26	cytochrome P450 family 2 subfamily D member 6	Homo sapiens	58-64	
12756210-7	2003	The present in vitro study suggests that buprenorphine and its major metabolite norbuprenorphine are inhibitors of CYP2D6 and CYP3A4; however, at therapeutic concentrations they are not predicted to cause potentially clinically important drug interactions with other drugs metabolized by major hepatic P450s.	Buprenorphine	41-54	cytochrome P450 family 2 subfamily D member 6	Homo sapiens	115-121