PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
25897175-7	2015	EDDP formation from therapeutic (0.25-1 muM) R- and S-methadone concentrations was CYP2B6.4 >= CYP2B6.1 >= CYP2B6.5 >> CYP2B6.9   CYP2B6.6, and undetectable from CYP2B6.18.	Methadone	54-63	latexin	Homo sapiens	40-43	
25196810-7	2015	The Ki values for methadone were 6.3 muM in SH-EP1-halpha7 cells and 19.4 muM and 1008 muM in SH-SY5Y cells.	Methadone	18-27	latexin	Homo sapiens	37-40	
25196810-7	2015	The Ki values for methadone were 6.3 muM in SH-EP1-halpha7 cells and 19.4 muM and 1008 muM in SH-SY5Y cells.	Methadone	18-27	latexin	Homo sapiens	74-77	
25196810-7	2015	The Ki values for methadone were 6.3 muM in SH-EP1-halpha7 cells and 19.4 muM and 1008 muM in SH-SY5Y cells.	Methadone	18-27	latexin	Homo sapiens	74-77	
20930594-5	2010	Methadone was less potent in hKv4.3/hKChIP2.2 (IC50 = 39.0 muM) and hKvLQT1/hminK (53.3 muM).	Methadone	0-9	latexin	Homo sapiens	88-91	
20930594-4	2010	Using patch clamp recording in human stem cell-derived cardiomyocytes and stably transfected mammalian cells, we found that methadone produced concentration-dependent AP prolongation and ion channel block at low micromolar concentrations: hERG (IC50 = 1.7 muM), hNav1.5 (11.2 muM tonic block; 5.5 muM phasic block), and hCav1.2 (26.7 muM tonic block; 7.7 muM phasic block).	Methadone	124-133	latexin	Homo sapiens	256-259	
20930594-4	2010	Using patch clamp recording in human stem cell-derived cardiomyocytes and stably transfected mammalian cells, we found that methadone produced concentration-dependent AP prolongation and ion channel block at low micromolar concentrations: hERG (IC50 = 1.7 muM), hNav1.5 (11.2 muM tonic block; 5.5 muM phasic block), and hCav1.2 (26.7 muM tonic block; 7.7 muM phasic block).	Methadone	124-133	latexin	Homo sapiens	276-279	
20930594-4	2010	Using patch clamp recording in human stem cell-derived cardiomyocytes and stably transfected mammalian cells, we found that methadone produced concentration-dependent AP prolongation and ion channel block at low micromolar concentrations: hERG (IC50 = 1.7 muM), hNav1.5 (11.2 muM tonic block; 5.5 muM phasic block), and hCav1.2 (26.7 muM tonic block; 7.7 muM phasic block).	Methadone	124-133	latexin	Homo sapiens	276-279	
20930594-4	2010	Using patch clamp recording in human stem cell-derived cardiomyocytes and stably transfected mammalian cells, we found that methadone produced concentration-dependent AP prolongation and ion channel block at low micromolar concentrations: hERG (IC50 = 1.7 muM), hNav1.5 (11.2 muM tonic block; 5.5 muM phasic block), and hCav1.2 (26.7 muM tonic block; 7.7 muM phasic block).	Methadone	124-133	latexin	Homo sapiens	276-279	
20930594-4	2010	Using patch clamp recording in human stem cell-derived cardiomyocytes and stably transfected mammalian cells, we found that methadone produced concentration-dependent AP prolongation and ion channel block at low micromolar concentrations: hERG (IC50 = 1.7 muM), hNav1.5 (11.2 muM tonic block; 5.5 muM phasic block), and hCav1.2 (26.7 muM tonic block; 7.7 muM phasic block).	Methadone	124-133	latexin	Homo sapiens	276-279	
20930594-5	2010	Methadone was less potent in hKv4.3/hKChIP2.2 (IC50 = 39.0 muM) and hKvLQT1/hminK (53.3 muM).	Methadone	0-9	latexin	Homo sapiens	59-62	
4740642-3	1973	The most potent drug in inhibiting the uptake of 5-HT (10 muM) by human platelets was methadone, followed by pentazocine>piminodine approximately pethidine approximately anileridine approximately cyclazocine approximately thebaine > dextropropoxyphene.	Methadone	86-95	latexin	Homo sapiens	58-61