PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 14572580-8 2003 The side effects of IFN therapy were no greater in the prior drug abusing population than in the controls, although many in the drug-abusing group increased their dose of methadone to counteract IFN side effects. Methadone 171-180 interferon alpha 1 Homo sapiens 195-198 10962774-0 2000 Psychosis in a methadone-substituted patient during interferon-alpha treatment of hepatitis C. Interferon-alpha (IFN-alpha) is the only effective treatment for chronic hepatitis B and C. Over 2/3 of methadone-substituted patients suffer from chronic hepatitis C but a history of psychiatric disorders or drug addiction is still seen as a contraindication for IFN-alpha because of a possible increased risk of severe psychiatric side effects such as depression, suicide attempts or psychotic episodes. Methadone 15-24 interferon alpha 1 Homo sapiens 113-122 10962774-0 2000 Psychosis in a methadone-substituted patient during interferon-alpha treatment of hepatitis C. Interferon-alpha (IFN-alpha) is the only effective treatment for chronic hepatitis B and C. Over 2/3 of methadone-substituted patients suffer from chronic hepatitis C but a history of psychiatric disorders or drug addiction is still seen as a contraindication for IFN-alpha because of a possible increased risk of severe psychiatric side effects such as depression, suicide attempts or psychotic episodes. Methadone 15-24 interferon alpha 1 Homo sapiens 359-368 10962774-0 2000 Psychosis in a methadone-substituted patient during interferon-alpha treatment of hepatitis C. Interferon-alpha (IFN-alpha) is the only effective treatment for chronic hepatitis B and C. Over 2/3 of methadone-substituted patients suffer from chronic hepatitis C but a history of psychiatric disorders or drug addiction is still seen as a contraindication for IFN-alpha because of a possible increased risk of severe psychiatric side effects such as depression, suicide attempts or psychotic episodes. Methadone 199-208 interferon alpha 1 Homo sapiens 113-122