PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 35194103-1 2022 Human CYP2B6 enzyme although constitutes relatively low proportion (1-4%) of hepatic cytochrome P450 content, it is the major catalyst of metabolism of several clinically important drugs (efavirenz, cyclophosphamide, bupropion, methadone). Methadone 228-237 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 85-100 34380995-3 2022 The mechanism of methadone metabolism and disposition has been shown to involve cytochrome P450 (CYP450) and P-glycoprotein. Methadone 17-26 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 80-95 30973652-1 2019 Different views appear in the literature on the extent of specific cytochrome P450 (CYP) involvement in methadone metabolism. Methadone 104-113 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 67-82 30973652-1 2019 Different views appear in the literature on the extent of specific cytochrome P450 (CYP) involvement in methadone metabolism. Methadone 104-113 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 84-87 30205091-2 2018 Methadone undergoes N-demethylation by multiple cytochrome P450 (CYP) enzymes including CYP3A4, CYP2B6, CYP2C19, CYP2D6, CYP2C9, and CYP2C8. Methadone 0-9 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 48-63 30205091-2 2018 Methadone undergoes N-demethylation by multiple cytochrome P450 (CYP) enzymes including CYP3A4, CYP2B6, CYP2C19, CYP2D6, CYP2C9, and CYP2C8. Methadone 0-9 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 65-68 30205091-5 2018 In general, CYP inhibitors altered methadone exposure with no adverse effects. Methadone 35-44 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 12-15 30205091-6 2018 CYP inducers generally decreased methadone exposure with some reports of withdrawal symptoms in the subjects. Methadone 33-42 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 0-3 30205091-8 2018 For certain antiviral medicines which are dual inhibitor(s) and inducer(s) for CYP enzymes, their effect on methadone pharmacokinetics can change with time since the effect of induction is usually delayed compared to the effect of inhibition. Methadone 108-117 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 79-82 27273149-0 2017 Pharmacokinetic Effects of Isavuconazole Coadministration With the Cytochrome P450 Enzyme Substrates Bupropion, Repaglinide, Caffeine, Dextromethorphan, and Methadone in Healthy Subjects. Methadone 157-166 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 67-82 29458047-0 2018 Effects of cytochrome P450 single nucleotide polymorphisms on methadone metabolism and pharmacodynamics. Methadone 62-71 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 11-26 29458047-4 2018 Methadone is primarily metabolized in the liver by cytochrome P450 (CYP) enzymes, predominately by CYP2B6, followed by CYP3A4, 2C19, 2D6, and to a lesser extent, CYP2C18, 3A7, 2C8, 2C9, 3A5, and 1A2. Methadone 0-9 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 51-66 29458047-4 2018 Methadone is primarily metabolized in the liver by cytochrome P450 (CYP) enzymes, predominately by CYP2B6, followed by CYP3A4, 2C19, 2D6, and to a lesser extent, CYP2C18, 3A7, 2C8, 2C9, 3A5, and 1A2. Methadone 0-9 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 68-71 29458047-9 2018 The involvement, contribution, and understanding the role of SNPs in CYP2B6, and other CYP genes, in methadone metabolism can improve the therapeutic uses of methadone in patient outcome and the development of personalized medicine. Methadone 101-110 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 69-72 29458047-9 2018 The involvement, contribution, and understanding the role of SNPs in CYP2B6, and other CYP genes, in methadone metabolism can improve the therapeutic uses of methadone in patient outcome and the development of personalized medicine. Methadone 158-167 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 69-72 21999760-5 2011 Opioids metabolized by the drug metabolizing enzymes of the cytochrome P450 (CYP450) system (codeine, oxycodone, hydrocodone, fentanyl, tramadol, and methadone) are associated with numerous DDIs that can result in either a reduction in opioid effect or excess opioid effects. Methadone 150-159 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 60-75 25278738-5 2013 Genes encoding the liver cytochrome P-450 (CYP) enzymes that are involved with the metabolism of methadone (CYP2B6, 3A4 and 2C19) were selected and genotyped in this cohort. Methadone 97-106 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 25-41 25278738-5 2013 Genes encoding the liver cytochrome P-450 (CYP) enzymes that are involved with the metabolism of methadone (CYP2B6, 3A4 and 2C19) were selected and genotyped in this cohort. Methadone 97-106 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 43-46 23879227-1 2013 Telaprevir (TVR) effects on P-glycloprotein and cytochrome P450 (CYP) may significantly elevate serum levels of morphine and methadone. Methadone 125-134 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 48-63 23879227-1 2013 Telaprevir (TVR) effects on P-glycloprotein and cytochrome P450 (CYP) may significantly elevate serum levels of morphine and methadone. Methadone 125-134 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 65-68 21999760-5 2011 Opioids metabolized by the drug metabolizing enzymes of the cytochrome P450 (CYP450) system (codeine, oxycodone, hydrocodone, fentanyl, tramadol, and methadone) are associated with numerous DDIs that can result in either a reduction in opioid effect or excess opioid effects. Methadone 150-159 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 77-83 19904716-2 2010 This method was established by the characteristics of recombinant cytochrome P-450 (CYP) isozymes, where CYP2C19 prefers to metabolize R-methadone and CYP2B6 prefers to metabolize S-methadone. Methadone 135-146 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 66-82 21694616-3 2011 In our previous study, we found that the cytochrome P-450 (CYP) isozyme 2B6 preferentially metabolizes the S-methadone enantiomer. Methadone 107-118 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 41-57 21694616-3 2011 In our previous study, we found that the cytochrome P-450 (CYP) isozyme 2B6 preferentially metabolizes the S-methadone enantiomer. Methadone 107-118 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 59-62 20825389-1 2011 In vitro metabolism of methadone was investigated in cytochrome P450 (CYP) supersomes and phenotyped human liver microsomes (HLMs) to reconcile past findings on CYP involvement in stereo-selective metabolism of methadone. Methadone 23-32 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 53-68 20825389-1 2011 In vitro metabolism of methadone was investigated in cytochrome P450 (CYP) supersomes and phenotyped human liver microsomes (HLMs) to reconcile past findings on CYP involvement in stereo-selective metabolism of methadone. Methadone 23-32 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 70-73 20825389-1 2011 In vitro metabolism of methadone was investigated in cytochrome P450 (CYP) supersomes and phenotyped human liver microsomes (HLMs) to reconcile past findings on CYP involvement in stereo-selective metabolism of methadone. Methadone 23-32 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 161-164 20825389-1 2011 In vitro metabolism of methadone was investigated in cytochrome P450 (CYP) supersomes and phenotyped human liver microsomes (HLMs) to reconcile past findings on CYP involvement in stereo-selective metabolism of methadone. Methadone 211-220 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 161-164 20825389-3 2011 CYP supersome activity for methadone use and EDDP formation ranked CYP2B6 > 3A4 > 2C19 > 2D6 > 2C18, 3A7 > 2C8, 2C9, 3A5. Methadone 27-36 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 0-3 19904716-2 2010 This method was established by the characteristics of recombinant cytochrome P-450 (CYP) isozymes, where CYP2C19 prefers to metabolize R-methadone and CYP2B6 prefers to metabolize S-methadone. Methadone 135-146 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 84-87 19904716-2 2010 This method was established by the characteristics of recombinant cytochrome P-450 (CYP) isozymes, where CYP2C19 prefers to metabolize R-methadone and CYP2B6 prefers to metabolize S-methadone. Methadone 180-191 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 66-82 19904716-2 2010 This method was established by the characteristics of recombinant cytochrome P-450 (CYP) isozymes, where CYP2C19 prefers to metabolize R-methadone and CYP2B6 prefers to metabolize S-methadone. Methadone 180-191 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 84-87 17178267-0 2006 ABCB1 and cytochrome P450 genotypes and phenotypes: influence on methadone plasma levels and response to treatment. Methadone 65-74 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 10-25 19133059-1 2009 AIMS: To investigate the influence of different cytochrome P450 (CYP) activities and other potential covariates on the disposition of methadone in patients on methadone maintenance therapy (MMT). Methadone 134-143 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 48-63 19133059-1 2009 AIMS: To investigate the influence of different cytochrome P450 (CYP) activities and other potential covariates on the disposition of methadone in patients on methadone maintenance therapy (MMT). Methadone 134-143 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 65-68 17178267-1 2006 BACKGROUND AND OBJECTIVE: The in vivo implication of various cytochrome P450 (CYP) isoforms and of P-glycoprotein on methadone kinetics is unclear. Methadone 117-126 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 78-81 17178267-12 2006 CONCLUSION: In vivo, CYP3A4 and CYP2B6 are the major CYP isoforms involved in methadone metabolism, with CYP2D6 contributing to a minor extent. Methadone 78-87 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 21-24 14628297-4 2004 The ability of the common human drug-metabolizing CYPs (obtained from baculovirus-infected insect cell supersomes) to generate 2-ethylidene-1,5-dimethyl-3,3-diphenylpyrrilidine (EDDP) from racemic methadone was examined and then determined if the CYP isoforms metabolized methadone stereoselectively. Methadone 197-206 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 50-53 14628297-1 2004 Methadone is a clinically used opioid agonist that is oxidatively metabolized by cytochrome P450 (CYP) isoforms to a stable metabolite, EDDP. Methadone 0-9 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 81-96 14628297-1 2004 Methadone is a clinically used opioid agonist that is oxidatively metabolized by cytochrome P450 (CYP) isoforms to a stable metabolite, EDDP. Methadone 0-9 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 98-101 14628297-3 2004 The cytochrome P450 (CYP) isoform involved in methadone"s metabolism is thought to be CYP3A4, but human drug-drug interaction studies are not consistent with this. Methadone 46-55 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 4-19 14628297-3 2004 The cytochrome P450 (CYP) isoform involved in methadone"s metabolism is thought to be CYP3A4, but human drug-drug interaction studies are not consistent with this. Methadone 46-55 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 21-24 15986265-5 2005 Before subjecting patients on methadone to other drugs, the QT-interval should be determined and it should be ascertained whether the new agent has the property to prolong the QT-interval or is metabolised by the cytochrome-P450 system. Methadone 30-39 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 213-228 14628297-4 2004 The ability of the common human drug-metabolizing CYPs (obtained from baculovirus-infected insect cell supersomes) to generate 2-ethylidene-1,5-dimethyl-3,3-diphenylpyrrilidine (EDDP) from racemic methadone was examined and then determined if the CYP isoforms metabolized methadone stereoselectively. Methadone 272-281 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 50-53