PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
28723731-8	2017	An increase in mean methadone C/D ratios was also seen for homozygous carriers of CYP3A5*3 and heterozygous carriers of CYP2C9*2 or *3 and CYP2C19*2 or *3.	Methadone	20-29	cytochrome P450 family 2 subfamily C member 9	Homo sapiens	120-126	
30205091-2	2018	Methadone undergoes N-demethylation by multiple cytochrome P450 (CYP) enzymes including CYP3A4, CYP2B6, CYP2C19, CYP2D6, CYP2C9, and CYP2C8.	Methadone	0-9	cytochrome P450 family 2 subfamily C member 9	Homo sapiens	121-127	
29457079-14	2017	When warfarin and methadone are used together, we have to consider their interaction by comparing the competitive inhibition of CYP2C9 to the induction of CYP3A4 by methadone, because CYP3A4 metabolize various drugs including oxycodone.	Methadone	18-27	cytochrome P450 family 2 subfamily C member 9	Homo sapiens	128-134	
16338275-2	2005	We aimed to determine the influence of CYP2B6, CYP2C9, and CYP2C19 genetic polymorphism on methadone pharmacokinetics and on the response to treatment.	Methadone	91-100	cytochrome P450 family 2 subfamily C member 9	Homo sapiens	47-53	
12900870-2	2003	Mephenytoin (MEPH), dextromethorphan, diclofenac, caffeine, and methadone (MET) were successfully applied as test substrates for CYP2C19, CYP2D6*1, CYP2C9*1, CYP1A2, and CYP3A4, respectively.	Methadone	64-73	cytochrome P450 family 2 subfamily C member 9	Homo sapiens	148-154	
14628297-7	2004	At 10 microg/ml of methadone, CYP2C9 and CYP2D6 also generated EDDP, but in at least 10-fold lower quantities than CYP2B6.	Methadone	19-28	cytochrome P450 family 2 subfamily C member 9	Homo sapiens	30-36	
12900870-2	2003	Mephenytoin (MEPH), dextromethorphan, diclofenac, caffeine, and methadone (MET) were successfully applied as test substrates for CYP2C19, CYP2D6*1, CYP2C9*1, CYP1A2, and CYP3A4, respectively.	Methadone	75-78	cytochrome P450 family 2 subfamily C member 9	Homo sapiens	148-154	
10233205-11	1999	CONCLUSIONS: The N-demethylation of methadone in human liver microsomes is not markedly stereoselective, and is mediated mainly by CYP3A4 with the possible involvement of CYP2C9 and CYP2C19.	Methadone	36-45	cytochrome P450 family 2 subfamily C member 9	Homo sapiens	171-177