PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
3211364-0	1988	Effects of exposure in utero to methadone and buprenorphine on enkephalin levels in the developing rat brain.	Methadone	32-41	proenkephalin	Rattus norvegicus	63-73	
6170377-1	1981	1 Morphine and related synthetic surrogates as well as beta-endorphin and methionine enkephalin caused a contractile response of the longitudinal musculature of the terminal colon of Long Evans rats.2 The muscular contraction caused by the narcotic analgesics exhibited stereospecificity, with levorphanol being about 50 times more potent than dextrorphan and (-)-methadone 4 times more potent than (+)-methadone.	Methadone	360-373	proenkephalin	Rattus norvegicus	85-95	
6170377-1	1981	1 Morphine and related synthetic surrogates as well as beta-endorphin and methionine enkephalin caused a contractile response of the longitudinal musculature of the terminal colon of Long Evans rats.2 The muscular contraction caused by the narcotic analgesics exhibited stereospecificity, with levorphanol being about 50 times more potent than dextrorphan and (-)-methadone 4 times more potent than (+)-methadone.	Methadone	399-412	proenkephalin	Rattus norvegicus	85-95	
3211364-3	1988	Methadone at 8 mg/kg but not 4 mg/kg significantly reduced enkephalin levels in the striatum.	Methadone	0-9	proenkephalin	Rattus norvegicus	59-69	
18587007-4	2008	On stimulation with selected agonists ([D-Ala(2),N-MePhe(4),Gly-ol(5)]enkephalin, enkephalin-heptapeptide Tyr-Gly-Gly-Phe-Met-Arg-Phe, morphine, and methadone), surface density of the MOP decreased, whereas the lateral mobility increased.	Methadone	149-158	proenkephalin	Rattus norvegicus	82-92