PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
19591810-11	2009	Furthermore, the method was used to determine the effects of methadone, buprenorphine, and morphine on paclitaxel transfer by placental P-gp and revealed that they have higher affinity to the transporter than its classical inhibitor verapamil (K(i), 300 microM).	Methadone	61-70	phosphoglycolate phosphatase	Homo sapiens	136-140	
17690563-2	2007	Using a cellular model, we aimed to determine if methadone, LAAM and their main metabolites are substrates of the human P-glycoprotein transporter (P-gp), which is encoded by the ABCB1 gene, and whether methadone transport exhibits stereoselectivity.	Methadone	49-58	phosphoglycolate phosphatase	Homo sapiens	120-146	
17690563-2	2007	Using a cellular model, we aimed to determine if methadone, LAAM and their main metabolites are substrates of the human P-glycoprotein transporter (P-gp), which is encoded by the ABCB1 gene, and whether methadone transport exhibits stereoselectivity.	Methadone	49-58	phosphoglycolate phosphatase	Homo sapiens	148-152	
17690563-2	2007	Using a cellular model, we aimed to determine if methadone, LAAM and their main metabolites are substrates of the human P-glycoprotein transporter (P-gp), which is encoded by the ABCB1 gene, and whether methadone transport exhibits stereoselectivity.	Methadone	203-212	phosphoglycolate phosphatase	Homo sapiens	120-146	
17690563-2	2007	Using a cellular model, we aimed to determine if methadone, LAAM and their main metabolites are substrates of the human P-glycoprotein transporter (P-gp), which is encoded by the ABCB1 gene, and whether methadone transport exhibits stereoselectivity.	Methadone	203-212	phosphoglycolate phosphatase	Homo sapiens	148-152	
17690563-4	2007	The intra- to extracellular ratios of methadone, LAAM and their metabolites were all decreased in ABCB1-transfected cells compared to controls (p < 0.05), thus indicating that they are substrates of P-gp.	Methadone	38-47	phosphoglycolate phosphatase	Homo sapiens	202-206	
17690563-6	2007	P-gp may therefore affect the pharmacokinetics and pharmacodynamics of methadone and LAAM.	Methadone	71-80	phosphoglycolate phosphatase	Homo sapiens	0-4	
16189332-9	2005	However, P-gp could only play a minor modulating role in man on the central effects of morphine, methadone and fentanyl.	Methadone	97-106	phosphoglycolate phosphatase	Homo sapiens	9-13