PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 7374351-0 1980 Effects of maternal methadone administration on ornithine decarboxylase in brain and heart of the offspring: relationships of enzyme activity to dose and to growth impairment in the rat. Methadone 20-29 ornithine decarboxylase 1 Rattus norvegicus 48-71 6125371-5 1982 Delays in the normal maturational decline of brain ornithine decarboxylase activity were prominent in the methadone group compared to offspring of pair-fed controls, just as reported previously in comparisons using non-pair-fed dams. Methadone 106-115 ornithine decarboxylase 1 Rattus norvegicus 51-74 978475-0 1976 Effects of neonatal or maternal methadone administration on ornithine decarboxylase activity in brain and heart of developing rats. Methadone 32-41 ornithine decarboxylase 1 Rattus norvegicus 60-83 633081-0 1978 Responses of heart ornithine decarboxylase and adrenal catecholamines to methadone and sympathetic stimulants in developing and adults rats. Methadone 73-82 ornithine decarboxylase 1 Rattus norvegicus 19-42 633081-3 1978 Methadone administration to adult rats stimulated heart ODC, and this stimulation could be blocked by the sympatholytic agents chlorisondamine, reserpine or propranolol, suggesting that the effect is mediated via central stimulation of sympathetic nerves. Methadone 0-9 ornithine decarboxylase 1 Rattus norvegicus 56-59 633081-4 1978 With repeated methadone administration, tolerance developed to the heart ODC stimulation by methadone, eventually resulting in decreased heart ODC accompanied by deficits in heart weight. Methadone 14-23 ornithine decarboxylase 1 Rattus norvegicus 73-76 633081-4 1978 With repeated methadone administration, tolerance developed to the heart ODC stimulation by methadone, eventually resulting in decreased heart ODC accompanied by deficits in heart weight. Methadone 14-23 ornithine decarboxylase 1 Rattus norvegicus 143-146 633081-4 1978 With repeated methadone administration, tolerance developed to the heart ODC stimulation by methadone, eventually resulting in decreased heart ODC accompanied by deficits in heart weight. Methadone 92-101 ornithine decarboxylase 1 Rattus norvegicus 73-76 633081-4 1978 With repeated methadone administration, tolerance developed to the heart ODC stimulation by methadone, eventually resulting in decreased heart ODC accompanied by deficits in heart weight. Methadone 92-101 ornithine decarboxylase 1 Rattus norvegicus 143-146 633081-7 1978 The cardiac responses to nicotine developed somewhat differently, with significant ODC stimulation first appearing at 12 days in controls and at 8 days in methadone-treated pups. Methadone 155-164 ornithine decarboxylase 1 Rattus norvegicus 83-86 978475-1 1976 Methadone was administered daily to pregnant or nursing rats, or directly to neonates, and the effects on brain and heart weights and ornithine decarboxylase (ODC) activities were determined during postnatal development. Methadone 0-9 ornithine decarboxylase 1 Rattus norvegicus 159-162 978475-2 1976 Exposure to methadone in the postnatal period either directly or via the mother resulted in delays in maturational decreases in brain ODC accompanied by deficits in brain weight. Methadone 12-21 ornithine decarboxylase 1 Rattus norvegicus 134-137 978475-4 1976 In the heart, direct methadone exposure or prenatal plus postnatal maternal administration led to a pattern of altered ODC activity consistent with delayed development, accompanied by heart weight deficits. Methadone 21-30 ornithine decarboxylase 1 Rattus norvegicus 119-122