PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
1837872-1	1991	The effect of Levomethadon on the amount of the lymphocyte subpopulation (CD4/CD8) was studied during 18 months in 18 HIV-infected heroin addicted patients.	Methadone	14-26	CD8a molecule	Homo sapiens	78-81	
7977217-9	1994	Our data indicate that methadone treatment, while not significantly affecting absolute CD4 lymphocyte count, is associated with a lower CD4 percentage and CD4/CD8 cell ratio, and with a higher CD8 absolute count and percentage.	Methadone	23-32	CD8a molecule	Homo sapiens	159-162	
7977217-9	1994	Our data indicate that methadone treatment, while not significantly affecting absolute CD4 lymphocyte count, is associated with a lower CD4 percentage and CD4/CD8 cell ratio, and with a higher CD8 absolute count and percentage.	Methadone	23-32	CD8a molecule	Homo sapiens	193-196	
1671730-7	1991	RESULTS: Significant differences were seen in lymphocyte phenotype in the methadone-treated group, with elevations in the T-cell helper subset CD4+CD26+; in CD8 and CD8+I2+ cells, suppressor/cytotoxic T lymphocytes, and activated suppressor/cytotoxic T cells; and in CD2+CD26+ cells and activated total T lymphocytes.	Methadone	74-83	CD8a molecule	Homo sapiens	157-160	
1671730-7	1991	RESULTS: Significant differences were seen in lymphocyte phenotype in the methadone-treated group, with elevations in the T-cell helper subset CD4+CD26+; in CD8 and CD8+I2+ cells, suppressor/cytotoxic T lymphocytes, and activated suppressor/cytotoxic T cells; and in CD2+CD26+ cells and activated total T lymphocytes.	Methadone	74-83	CD8a molecule	Homo sapiens	165-168	
31969385-0	2020	Chronic Methadone Use Alters the CD8+ T Cell Phenotype In Vivo and Modulates Its Responsiveness Ex Vivo to Opioid Receptor and TCR Stimuli.	Methadone	8-17	CD8a molecule	Homo sapiens	33-36	
31969385-5	2020	From a cohort of nonuser controls and methadone users, we demonstrate, via t-Stochastic Neighbor Embedding and k-means cluster analysis of surface marker expression, that chronic opioid use alters human CD8+ T cell subset balance, with notable decreases in T effector memory RA+ cells.	Methadone	38-47	CD8a molecule	Homo sapiens	203-206	
31969385-8	2020	CD8+ T cells from controls exposed to mu-OR agonists ex vivo decrease expression of activation markers CD69 and CD25, although the same markers are elevated in mu-OR-treated cells from methadone users.	Methadone	185-194	CD8a molecule	Homo sapiens	0-3