PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
7977217-9	1994	Our data indicate that methadone treatment, while not significantly affecting absolute CD4 lymphocyte count, is associated with a lower CD4 percentage and CD4/CD8 cell ratio, and with a higher CD8 absolute count and percentage.	Methadone	23-32	CD4 molecule	Homo sapiens	136-139	
11743707-0	2001	Long-term methadone treatment: effect on CD4+ lymphocyte counts and HIV-1 plasma RNA level in patients with HIV infection.	Methadone	10-19	CD4 molecule	Homo sapiens	41-44	
11743707-1	2001	The objective was to examine the effect of methadone on CD4+ lymphocyte counts and viral load and to expect to document the safety of methadone maintenance in patients with human immune deficiency syndrome.	Methadone	43-52	CD4 molecule	Homo sapiens	56-59	
11743707-8	2001	The slope of regression of CD4+ count showed a significantly steeper decline in the methadone-using patients compared with the methadone non-users (r= 0.487; p< 0.05).	Methadone	84-93	CD4 molecule	Homo sapiens	27-30	
11743707-8	2001	The slope of regression of CD4+ count showed a significantly steeper decline in the methadone-using patients compared with the methadone non-users (r= 0.487; p< 0.05).	Methadone	127-136	CD4 molecule	Homo sapiens	27-30	
11743707-10	2001	Long-term methadone use was associated with a significantly faster decrease of CD4+ count in HIV-1 affected patients compared with methadone non-users.	Methadone	10-19	CD4 molecule	Homo sapiens	79-82	
9445761-9	1996	Kaplan-Meier estimates indicated that patients with methadone had better survival (p=0.0002) after 200 CD4 cells and in matched pairs with a mean CD4 count of 520 +/- 315/microl at baseline CD4 slopes did no differ significantly.	Methadone	52-61	CD4 molecule	Homo sapiens	103-106	
7977217-9	1994	Our data indicate that methadone treatment, while not significantly affecting absolute CD4 lymphocyte count, is associated with a lower CD4 percentage and CD4/CD8 cell ratio, and with a higher CD8 absolute count and percentage.	Methadone	23-32	CD4 molecule	Homo sapiens	136-139	
1837872-1	1991	The effect of Levomethadon on the amount of the lymphocyte subpopulation (CD4/CD8) was studied during 18 months in 18 HIV-infected heroin addicted patients.	Methadone	14-26	CD4 molecule	Homo sapiens	74-77	
32433362-2	2020	The study aimed to identify key factors associated with the increased cluster of differentiation 4 (CD4) cell counts among HIV-positive people who inject heroin and receive methadone maintenance treatment (MMT).	Methadone	173-182	CD4 molecule	Homo sapiens	100-103	
26831364-12	2016	Our findings suggest that on-site point-of-care CD4 testing, a peer support system, and trained HIV treatment specialists who are able to counsel HIV-positive clients and initiate them on ART at the methadone clinic could help reduce barriers to timely ART initiation for methadone clients.	Methadone	199-208	CD4 molecule	Homo sapiens	48-51	
1671730-7	1991	RESULTS: Significant differences were seen in lymphocyte phenotype in the methadone-treated group, with elevations in the T-cell helper subset CD4+CD26+; in CD8 and CD8+I2+ cells, suppressor/cytotoxic T lymphocytes, and activated suppressor/cytotoxic T cells; and in CD2+CD26+ cells and activated total T lymphocytes.	Methadone	74-83	CD4 molecule	Homo sapiens	143-146	
26009835-7	2015	Clients receiving high methadone doses (>= 85 mg/d) [adjusted hazard ratio (aHR): 1.68, 95% CI: 1.03 to 2.74] had higher likelihood of CD4 screening than those receiving low doses (<85 mg/d).	Methadone	23-32	CD4 molecule	Homo sapiens	138-141	
25834861-3	2015	C-C chemokine receptor type 5 (CCR5) expression on CD4+ cells was higher in heroin (P = 0.007), methadone (P = 0.024) and former opioid users (P = 0.003) compared to nonusers, whereas production of RANTES and other CCR5 ligands was similar or lower.	Methadone	96-105	CD4 molecule	Homo sapiens	51-54