PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
24117196-0	2014	The opioid methadone induces a local anaesthetic-like inhibition of the cardiac Na+ channel, Na(v)1.5.	Methadone	11-20	immunoglobulin lambda variable 2-18	Homo sapiens	93-101	
24117196-3	2014	Considering the common assumption that an inhibition of the cardiac Na+ channel Na(v)1.5, is the primary mechanism for local anaesthetic (LA)-induced cardiotoxicity, we hypothesized that methadone has LA-like properties leading to a modulation of Na(v)1.5 channels.	Methadone	187-196	immunoglobulin lambda variable 2-18	Homo sapiens	80-88	
24117196-3	2014	Considering the common assumption that an inhibition of the cardiac Na+ channel Na(v)1.5, is the primary mechanism for local anaesthetic (LA)-induced cardiotoxicity, we hypothesized that methadone has LA-like properties leading to a modulation of Na(v)1.5 channels.	Methadone	187-196	immunoglobulin lambda variable 2-18	Homo sapiens	247-255	
24117196-4	2014	EXPERIMENTAL APPROACH: The whole-cell patch clamp technique was applied to investigate the effects of methadone on wild-type and mutant human Na(v)1.5 channels expressed in HEK293 cells.	Methadone	102-111	immunoglobulin lambda variable 2-18	Homo sapiens	142-150	
24117196-6	2014	KEY RESULTS: Methadone inhibited Na(v)1.5 channels in a state-dependent manner, that is, tonic block was stronger with inactivated channels than with resting channels and a use-dependent block at 10 Hz.	Methadone	13-22	immunoglobulin lambda variable 2-18	Homo sapiens	33-41	
24117196-10	2014	CONCLUSIONS AND IMPLICATIONS: Methadone interacted with the LA-binding site to inhibit Na(v)1.5 channels.	Methadone	30-39	immunoglobulin lambda variable 2-18	Homo sapiens	87-95