PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
31280015-0	2019	Ultrasound-assisted synthesis of novel chalcone, heterochalcone and bis-chalcone derivatives and the evaluation of their antioxidant properties and as acetylcholinesterase inhibitors.	Chalcone	39-47	acetylcholinesterase (Cartwright blood group)	Homo sapiens	151-171	
31878304-2	2019	Herein, we focus on generating 12 chalcone-donepezil hybrids, with the goal of simultaneously targeting amyloid-beta (Abeta) peptides as well as cholinesterases (i.e., acetylcholinesterase (AChE) and butyrylcholinesterase (BChE)).	Chalcone	34-42	acetylcholinesterase (Cartwright blood group)	Homo sapiens	168-188	
29934672-0	2018	Structure-activity relationship investigation of coumarin-chalcone hybrids with diverse side-chains as acetylcholinesterase and butyrylcholinesterase inhibitors.	Chalcone	58-66	acetylcholinesterase (Cartwright blood group)	Homo sapiens	103-123	
30622011-4	2019	These chalcone derivatives had Ki values in the range of 19.58-78.73 nM for hCA I, 12.23-41.70 nM for hCA II, 1.09-6.84 nM for AChE, 8.30-32.30 nM for BChE and 0.93 +- 0.20-18.53 +- 5.06 nM against alpha-glycosidase.	Chalcone	6-14	acetylcholinesterase (Cartwright blood group)	Homo sapiens	127-131	
30431690-3	2019	In this study, the inhibition effects of chalcone and its epoxidated derivative chalcone epoxide against human carbonic anhydrase isozymes I and II (hCA I and hCA II), acetylcholinesterase (AChE), and butyrylcholinesterase (BuChE) were evaluated.	Chalcone	41-49	acetylcholinesterase (Cartwright blood group)	Homo sapiens	168-188	
30431690-3	2019	In this study, the inhibition effects of chalcone and its epoxidated derivative chalcone epoxide against human carbonic anhydrase isozymes I and II (hCA I and hCA II), acetylcholinesterase (AChE), and butyrylcholinesterase (BuChE) were evaluated.	Chalcone	41-49	acetylcholinesterase (Cartwright blood group)	Homo sapiens	190-194	
29934672-3	2018	Here, we report the synthesis and testing of 36 new coumarin-chalcone hybrids (5d-7j, 9d-11f, 12k-13m) against AChE and BChE.	Chalcone	61-69	acetylcholinesterase (Cartwright blood group)	Homo sapiens	111-115	
29934672-4	2018	The nature and position of the chalcone substituents had major effects on inhibitory activity as well as selectivity for AChE over BChE.	Chalcone	31-39	acetylcholinesterase (Cartwright blood group)	Homo sapiens	121-125	
29934672-5	2018	Compounds with para-substituted chalcone fragments in which the substituents were choline-like had potent activity against AChE and poor activity against BChE, while ortho-substituted analogs exhibited an opposite effect.	Chalcone	32-40	acetylcholinesterase (Cartwright blood group)	Homo sapiens	123-127	
29934672-9	2018	Overall, the results show that coumarin-chalcone hybrids with choline-like side-chains have promising activity and selectivity against AChE and be promising therapeutic leads for Alzheimer"s disease.	Chalcone	40-48	acetylcholinesterase (Cartwright blood group)	Homo sapiens	135-139	
28687725-7	2017	CONCLUSIONS In conclusion, our study revealed a novel class of chalcone derivatives as a selective inhibitor of AChE with considerably action against beta-secretase and Abeta aggregation.	Chalcone	63-71	acetylcholinesterase (Cartwright blood group)	Homo sapiens	112-116	
26186269-0	2016	Design, synthesis and preliminary structure-activity relationship investigation of nitrogen-containing chalcone derivatives as acetylcholinesterase and butyrylcholinesterase inhibitors: a further study based on Flavokawain B Mannich base derivatives.	Chalcone	103-111	acetylcholinesterase (Cartwright blood group)	Homo sapiens	127-147	
26186269-2	2016	The results suggested that amino alkyl side chain of chalcone dramatically influenced the inhibitory activity against AChE.	Chalcone	53-61	acetylcholinesterase (Cartwright blood group)	Homo sapiens	118-122	
25260958-0	2014	Design, synthesis and pharmacological evaluation of chalcone derivatives as acetylcholinesterase inhibitors.	Chalcone	52-60	acetylcholinesterase (Cartwright blood group)	Homo sapiens	76-96	
25260958-1	2014	A novel series of chalcone derivatives (4a-8d) were designed, synthesized, and evaluated for the inhibition activity against acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE).	Chalcone	18-26	acetylcholinesterase (Cartwright blood group)	Homo sapiens	125-145	
25260958-1	2014	A novel series of chalcone derivatives (4a-8d) were designed, synthesized, and evaluated for the inhibition activity against acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE).	Chalcone	18-26	acetylcholinesterase (Cartwright blood group)	Homo sapiens	147-151