PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
32321826-4	2020	Methyl vinyl ketone oxide (MVK-oxide) is a four-carbon, asymmetric, resonance-stabilized CI, produced with 21 to 23% yield from isoprene ozonolysis, yet its reactivity has not been directly studied.	isoprene	128-136	mevalonate kinase	Homo sapiens	27-30	
35568171-8	2022	Methyl vinyl ketone and methacrolein (MVK + MACR) exhibited contributions from both secondary photooxidation of isoprene and direct emissions from traffic.	isoprene	112-120	mevalonate kinase	Homo sapiens	38-41	
33211784-3	2020	This study focuses on characterizing the catalyzed isomerization and adduct formation pathways for the reaction between formic acid and methyl vinyl ketone oxide (MVK-oxide), a four-carbon unsaturated Criegee intermediate generated from isoprene ozonolysis.	isoprene	237-245	mevalonate kinase	Homo sapiens	163-166	
34065491-6	2021	The results are compared to analogous studies on the reaction of formic acid with methyl vinyl ketone oxide (MVK-oxide), the other four-carbon Criegee intermediate in isoprene ozonolysis.	isoprene	167-175	mevalonate kinase	Homo sapiens	109-112	
28068985-6	2017	The optimized process using 10 balanced enzyme unites (5.0 microM of MVK, PMK, MVD; 10.0 microM of IDI, 80.0 microM of ISPS) could produce 6323.5 micromol/L/h (430 mg/L/h) isoprene in a 2 ml in vitro system.	isoprene	172-180	mevalonate kinase	Homo sapiens	69-72	
30599734-1	2018	Ozonolysis of isoprene, one of the most abundant volatile organic compounds in the atmosphere, proceeds through methyl vinyl ketone oxide (MVK-oxide), methacrolein oxide, and formaldehyde oxide (CH2OO) Criegee intermediates.	isoprene	14-22	mevalonate kinase	Homo sapiens	139-142	
30074392-3	2018	In particular, unimolecular decay of MVK-OO is predicted to be the major source of hydroxyl radicals (OH) in isoprene ozonolysis.	isoprene	109-117	mevalonate kinase	Homo sapiens	37-40	
10401001-0	1999	Identification and characterization of three novel missense mutations in mevalonate kinase cDNA causing mevalonic aciduria, a disorder of isoprene biosynthesis.	isoprene	138-146	mevalonate kinase	Homo sapiens	73-90	
21425920-1	2011	Defects in mevalonate kinase, a critical rate-limiting enzyme in cholesterol and isoprene metabolism, have been associated with 2 clinical phenotypes: mevalonic aciduria, which presents in infancy or early childhood with growth failure, dysmorphic features, and neurologic disease; and hyperimmunoglobulinemia D and periodic fever syndrome, which usually presents outside the neonatal period as an autoinflammatory periodic fever syndrome.	isoprene	81-89	mevalonate kinase	Homo sapiens	11-28	
34742186-1	2021	The electronic spectrum of methyl vinyl ketone oxide (MVK-oxide), a four-carbon Criegee intermediate derived from isoprene ozonolysis, is examined on its second pi*   pi transition, involving primarily the vinyl group, at UV wavelengths (lambda) below 300 nm.	isoprene	114-122	mevalonate kinase	Homo sapiens	54-57	
9392419-0	1997	Post-translational regulation of mevalonate kinase by intermediates of the cholesterol and nonsterol isoprene biosynthetic pathways.	isoprene	101-109	mevalonate kinase	Homo sapiens	33-50	
9392419-7	1997	These results provide additional evidence that MKase may occupy a central regulatory role in the control of cholesterol and nonsterol isoprene biosynthesis.	isoprene	134-142	mevalonate kinase	Homo sapiens	47-52	
1377680-1	1992	Mevalonic aciduria is the first proposed inherited disorder of the cholesterol/isoprene biosynthetic pathway in humans, and it is presumed to be caused by a mutation in the gene coding for mevalonate kinase.	isoprene	79-87	mevalonate kinase	Homo sapiens	189-206	
34438153-5	2021	Following the initial reactions, their subsequent reactions with O2 and HO2 (or NO) under different atmospheric conditions could lead to the formation of 17 highly oxidized molecules (HOMs), of which P10, P12, P16, P17, P19 and P33 generated by the subsequent reactions of the major first-generation products (MVK, CMBO, CMBA and MBO) have been detected in the reaction process of isoprene with Cl in the chamber experiment.	isoprene	381-389	mevalonate kinase	Homo sapiens	310-313