PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 12645137-2 2003 The contiguous asymmetric centers at C-3a and C-6a were formed through a diastereoselective aldol reaction of N-Cbz-3-amino-4-butanolide 5 to provide trans-disubstituted lactone 6 with high stereoselectivity (trans/cis = 12:1). n-cbz-3-amino-4-butanolide 110-136 complement C3 Homo sapiens 37-41