PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 11877411-1 2002 Mevalonate kinase catalyzes the ATP-dependent phosphorylation of mevalonic acid to form mevalonate 5-phosphate, a key intermediate in the pathways of isoprenoids and sterols. Mevalonic Acid 65-79 mevalonate kinase Homo sapiens 0-17 11698677-6 2001 All three enzymes responsible for synthesis of isopentenyl diphosphate from mevalonate (mevalonate kinase, phosphomevalonate kinase, and MDD) share the same fold, catalyze phosphorylation of chemically similar substrates (MDD decarboxylation involves phosphorylation of mevalonate diphosphate), and seem to have evolved from a common ancestor. Mevalonic Acid 76-86 mevalonate kinase Homo sapiens 88-105 9334262-15 1997 Our results indicate that the bacterial expression system for human MKase will provide a useful model system in which to analyze inherited mutations and identify the first active site residue in MKase associated with stabilization of mevalonate binding. Mevalonic Acid 234-244 mevalonate kinase Homo sapiens 68-73 11111075-1 2000 Mevalonate kinase (MK) is an essential enzyme in the mevalonate pathway which produces numerous cellular isoprenoids. Mevalonic Acid 53-63 mevalonate kinase Homo sapiens 0-17 11111075-1 2000 Mevalonate kinase (MK) is an essential enzyme in the mevalonate pathway which produces numerous cellular isoprenoids. Mevalonic Acid 53-63 mevalonate kinase Homo sapiens 19-21 9523093-1 1998 PURPOSE: Mevalonic aciduria in humans results from a genetic deficiency of mevalonate kinase and is characterized by very high plasma mevalonic acid levels, developmental malformations and cataracts. Mevalonic Acid 134-148 mevalonate kinase Homo sapiens 75-92 9334262-15 1997 Our results indicate that the bacterial expression system for human MKase will provide a useful model system in which to analyze inherited mutations and identify the first active site residue in MKase associated with stabilization of mevalonate binding. Mevalonic Acid 234-244 mevalonate kinase Homo sapiens 195-200 34950147-1 2021 Mevalonic aciduria (MA) is the most severe clinical subtype of mevalonate kinase deficiency (MKD) caused by an inherited defect in the mevalonate pathway. Mevalonic Acid 135-145 mevalonate kinase Homo sapiens 63-80 7747441-4 1995 Our results suggest that the enhanced and inappropriate expression of Mk may lead to increased metabolism of mevalonate and phosphorylation of hitherto unknown cellular proteins. Mevalonic Acid 109-119 mevalonate kinase Homo sapiens 70-72 8302606-5 1994 MK phosphorylates mevalonate, a major intermediate in the branched cholesterol/isoprenoid biosynthetic pathway. Mevalonic Acid 18-28 mevalonate kinase Homo sapiens 0-2 33410495-8 2021 The persistence of urinary excretion of mevalonic acid after SCT, probably related to the ubiquitous expression of MVK enzyme, suggests that these patients should be carefully monitored after SCT to exclude MKD clinical recurrence. Mevalonic Acid 40-54 mevalonate kinase Homo sapiens 115-118 32974183-3 2020 SREBP-2 binds to the sterol regulatory elements (SREs) in the promoters of its target genes and activates the transcription of mevalonate pathway genes, such as HMG-CoA reductase (HMGCR), mevalonate kinase and other key enzymes. Mevalonic Acid 127-137 mevalonate kinase Homo sapiens 188-205 32290231-5 2020 In correlation with mutp53 reduction and wtp53 activation, PBA downregulated the expression level of mevalonate kinase (MVK), a key kinase of the mevalonate pathway strongly involved in cancer cell survival. Mevalonic Acid 101-111 mevalonate kinase Homo sapiens 120-123 29722423-3 2018 We performed Sanger sequencing of exons and flanking intron-exon boundaries of mevalonate pathway genes (MVD, MVK, PMVK and FDPS) and of SLC17A9. Mevalonic Acid 79-89 mevalonate kinase Homo sapiens 110-113 31207227-1 2019 Patients with disseminated superficial actinic porokeratosis (DSAP) and linear porokeratosis (LP) exhibit monoallelic germline mutations in genes encoding mevalonate pathway enzymes, such as MVD or MVK. Mevalonic Acid 155-165 mevalonate kinase Homo sapiens 198-201 30735219-1 2019 Mevalonate Kinase (MVK) catalyses the ATP-Mg2+ mediated phosphate transfer of mevalonate to produce mevalonate 5-phosphate and is a key kinase in the mevalonate pathway in the biosynthesis of isopentenyl diphosphate, the precursor of isoprenoid-based biofuels. Mevalonic Acid 78-88 mevalonate kinase Homo sapiens 0-17 30735219-1 2019 Mevalonate Kinase (MVK) catalyses the ATP-Mg2+ mediated phosphate transfer of mevalonate to produce mevalonate 5-phosphate and is a key kinase in the mevalonate pathway in the biosynthesis of isopentenyl diphosphate, the precursor of isoprenoid-based biofuels. Mevalonic Acid 78-88 mevalonate kinase Homo sapiens 19-22 30735219-1 2019 Mevalonate Kinase (MVK) catalyses the ATP-Mg2+ mediated phosphate transfer of mevalonate to produce mevalonate 5-phosphate and is a key kinase in the mevalonate pathway in the biosynthesis of isopentenyl diphosphate, the precursor of isoprenoid-based biofuels. Mevalonic Acid 100-110 mevalonate kinase Homo sapiens 0-17 30735219-1 2019 Mevalonate Kinase (MVK) catalyses the ATP-Mg2+ mediated phosphate transfer of mevalonate to produce mevalonate 5-phosphate and is a key kinase in the mevalonate pathway in the biosynthesis of isopentenyl diphosphate, the precursor of isoprenoid-based biofuels. Mevalonic Acid 100-110 mevalonate kinase Homo sapiens 19-22 30735219-3 2019 Here using molecular docking, molecular dynamics (MD) simulations and a hybrid QM/MM study, we revisited the location of Mg2+ resolved in the crystal structure of MVK and determined a catalytically competent MVK structure in complex with the native substrate mevalonate and ATP. Mevalonic Acid 259-269 mevalonate kinase Homo sapiens 208-211 30735219-7 2019 Remarkably, we revealed that the phosphorylation of mevalonate catalyzed by MVK occurs via a direct phosphorylation mechanism, instead of the conventionally postulated catalytic base mechanism. Mevalonic Acid 52-62 mevalonate kinase Homo sapiens 76-79 29374778-2 2018 Trying to clarify the effects of MVK gene impairment on the mevalonate pathway we used a yeast model, the erg12-d mutant strain Saccharomyces cerevisiae (orthologous of MKV) retaining only 10% of mevalonate kinase (MK) activity, to describe the effects of reduced MK activity on the mevalonate pathway. Mevalonic Acid 60-70 mevalonate kinase Homo sapiens 33-36 24879560-1 2014 In the present study, we found that three enzymes, MVK, MDD and FPPS, in the mevalonate pathway (MVP) of cholesterol biosynthesis, can be simultaneously inhibited by two green tea polyphenols ((-)-epicatechin-3-gallate, ECG; (-)-epigallocatechin-3-gallate, EGCG). Mevalonic Acid 77-87 mevalonate kinase Homo sapiens 51-54 29238070-4 2018 Specific reduction of mevalonate-5-phosphate (MVP), a metabolic intermediate in the mevalonate pathway, by statins or mevalonate kinase (MVK) knockdown triggers CHIP ubiquitin ligase-mediated degradation of conformational mutp53 by inhibiting interaction between mutp53 and DNAJA1, a Hsp40 family member. Mevalonic Acid 22-32 mevalonate kinase Homo sapiens 118-135 29238070-4 2018 Specific reduction of mevalonate-5-phosphate (MVP), a metabolic intermediate in the mevalonate pathway, by statins or mevalonate kinase (MVK) knockdown triggers CHIP ubiquitin ligase-mediated degradation of conformational mutp53 by inhibiting interaction between mutp53 and DNAJA1, a Hsp40 family member. Mevalonic Acid 22-32 mevalonate kinase Homo sapiens 137-140 28901277-2 2018 In MKD, defective function of the enzyme mevalonate kinase, due to a mutation in the MVK gene, leads to the shortage of mevalonate- derived intermediates, which results in unbalanced prenylation of proteins and altered metabolism of sterols. Mevalonic Acid 41-51 mevalonate kinase Homo sapiens 85-88 28777842-3 2017 PCR and direct sequencing were carried out for five patients from a family, 4 sporadic cases, and 120 healthy controls to identify potential mutations of four genes (MVK, MVD, PMVK, FDPS) involved in the mevalonate pathway as well as SLC17A9, SSH1, and SART3 genes. Mevalonic Acid 204-214 mevalonate kinase Homo sapiens 166-169 26409462-11 2016 Further, a positive urinary mevalonic acid excretion still requires MVK analysis to confirm the diagnosis of MKD. Mevalonic Acid 28-42 mevalonate kinase Homo sapiens 68-71 26409462-13 2016 However, as long as genetic testing is not widely available and affordable, measurement of urinary mevalonic acid is a fair way to select patients for MVK gene analysis or enzyme assay. Mevalonic Acid 99-113 mevalonate kinase Homo sapiens 151-154 26420133-1 2015 Mevalonate kinase (MVK) catalyses the phosphorylation of mevalonate. Mevalonic Acid 57-67 mevalonate kinase Homo sapiens 0-17 26420133-1 2015 Mevalonate kinase (MVK) catalyses the phosphorylation of mevalonate. Mevalonic Acid 57-67 mevalonate kinase Homo sapiens 19-22 28918367-3 2017 MVK mutations have been reported as associated with impairment of mevalonate pathway with consequent decrease of protein prenylation levels, defective autophagy and increase of IL-1beta secretion, followed by cell death. Mevalonic Acid 66-76 mevalonate kinase Homo sapiens 0-3 27012807-5 2016 Mevalonate kinase deficiency was suspected on the basis of clinical (hydrops fetalis, hepatosplenomegaly, hypotonia) and laboratory signs (anaemia, intense acute phase reaction, increased urinary excretion of mevalonic acid). Mevalonic Acid 209-223 mevalonate kinase Homo sapiens 0-17 26300074-5 2015 V377I as well as the S135L mutations were identified on the mevalonate kinase deficiency gene and the levels of mevalonic acid in the patient were 5,496 microg/ml. Mevalonic Acid 112-126 mevalonate kinase Homo sapiens 60-77 26184189-6 2015 This mechanism could play a significant role in Mevalonate Kinase Deficiency, an autoinflammatory disease characterized by a defect in Mevalonate Kinase, a key enzyme of the mevalonate pathway. Mevalonic Acid 174-184 mevalonate kinase Homo sapiens 48-65 14749336-8 2004 Inhibition of LHR mRNA binding activity of mevalonate kinase in the presence of ATP and mevalonate indicates that the RNA recognition site of mevalonate kinase might involve the ATP/mevalonate binding region of the protein. Mevalonic Acid 43-53 mevalonate kinase Homo sapiens 142-159 24360083-1 2013 BACKGROUND: Mevalonate kinase deficiency (MKD) is caused by mutations in the MVK gene, encoding the second enzyme of mevalonate pathway, which results in subsequent shortage of downstream compounds, and starts in childhood with febrile attacks, skin, joint, and gastrointestinal symptoms, sometimes induced by vaccinations. Mevalonic Acid 117-127 mevalonate kinase Homo sapiens 77-80 23428571-2 2013 Four enzymes in mevalonate pathway, including MVK, PMK, MDD, and FPPS, play important regulatory roles in cholesterol biosynthesis and cell proliferation. Mevalonic Acid 16-26 mevalonate kinase Homo sapiens 46-49 23110805-3 2013 Mutations in both copies of the MVK-gene lead to a block in the mevalonate pathway. Mevalonic Acid 64-74 mevalonate kinase Homo sapiens 32-35 23168296-2 2013 MKD is due to mutations in the second enzyme of mevalonate pathway (mevalonate kinase, MK/MVK) which results in reduced enzymatic activity and in the consequent shortage of downstream compounds. Mevalonic Acid 48-58 mevalonate kinase Homo sapiens 68-85 23168296-2 2013 MKD is due to mutations in the second enzyme of mevalonate pathway (mevalonate kinase, MK/MVK) which results in reduced enzymatic activity and in the consequent shortage of downstream compounds. Mevalonic Acid 48-58 mevalonate kinase Homo sapiens 90-93 14749336-8 2004 Inhibition of LHR mRNA binding activity of mevalonate kinase in the presence of ATP and mevalonate indicates that the RNA recognition site of mevalonate kinase might involve the ATP/mevalonate binding region of the protein. Mevalonic Acid 88-98 mevalonate kinase Homo sapiens 43-60 14749336-8 2004 Inhibition of LHR mRNA binding activity of mevalonate kinase in the presence of ATP and mevalonate indicates that the RNA recognition site of mevalonate kinase might involve the ATP/mevalonate binding region of the protein. Mevalonic Acid 88-98 mevalonate kinase Homo sapiens 142-159 14749336-9 2004 Treatment of 293 cells with mevastatin to deplete cellular mevalonate resulted in an increase in LHR mRNA binding activity of mevalonate kinase. Mevalonic Acid 59-69 mevalonate kinase Homo sapiens 126-143 12477733-9 2003 Thus, it appears that the elevation of mevalonate levels, which are high in MA patients and moderate in HIDS patients, allows the cells to compensate for the depressed MK activity. Mevalonic Acid 39-49 mevalonate kinase Homo sapiens 168-170 12477733-11 2003 Our results indicate that MK-deficient cells maintain the flux through the isoprenoid/cholesterol biosynthesis pathway by elevating intracellular mevalonate levels. Mevalonic Acid 146-156 mevalonate kinase Homo sapiens 26-28