PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
28066443-5	2016	The precise mechanisms by which IFN regulates the mevalonate-sterol pathway-the spine of the network-are beginning to be unraveled.	Mevalonic Acid	50-60	interferon alpha 1	Homo sapiens	32-35	
30886604-2	2019	Notably, while the IFN antiviral response is known to be directly coupled to mevalonate-sterol biosynthesis, mechanistic insight for providing host pathway-therapeutic targets remain incomplete.	Mevalonic Acid	77-87	interferon alpha 1	Homo sapiens	19-22	
27692616-3	2016	Altered flux through the mevalonic acid synthesis pathway also appears to be a required event in the antiviral interferon (IFN) response of macrophages and in the activation, proliferation, and differentiation of T cells.	Mevalonic Acid	25-39	interferon alpha 1	Homo sapiens	111-121	
27692616-3	2016	Altered flux through the mevalonic acid synthesis pathway also appears to be a required event in the antiviral interferon (IFN) response of macrophages and in the activation, proliferation, and differentiation of T cells.	Mevalonic Acid	25-39	interferon alpha 1	Homo sapiens	123-126	
25759117-3	2015	Here, we elucidate the molecular circuitry governing how IFN controls the first regulated step in the mevalonate-sterol pathway, 3-hydroxy-3-methylglutaryl-CoA reductase (HMGCR), through the synthesis of 25-Hydroxycholesterol (25-HC) from cholesterol by the IFN-inducible Cholesterol-25-Hydroxylase (CH25H).	Mevalonic Acid	102-112	interferon alpha 1	Homo sapiens	57-60	
25759117-3	2015	Here, we elucidate the molecular circuitry governing how IFN controls the first regulated step in the mevalonate-sterol pathway, 3-hydroxy-3-methylglutaryl-CoA reductase (HMGCR), through the synthesis of 25-Hydroxycholesterol (25-HC) from cholesterol by the IFN-inducible Cholesterol-25-Hydroxylase (CH25H).	Mevalonic Acid	102-112	interferon alpha 1	Homo sapiens	258-261	
25759117-9	2015	In conclusion, we quantitatively delineate proteomic and transcriptional levels of IFN-mediated control of HMGCR, the primary enzymatic step of the mevalonate-sterol biosynthesis pathway, providing a foundational framework for mathematically modelling the therapeutic outcome of immune-metabolic pathways.	Mevalonic Acid	148-158	interferon alpha 1	Homo sapiens	83-86