PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 7509201-1 1994 A tetrasaccharide related to the blood group oligosaccharides, known as sialyl LewisX, has been proposed as the receptor for the lectin responsible for leukocyte adhesion named alternatively as E-selectin or ELAM-1. Oligosaccharides 45-61 selectin E Homo sapiens 194-204 27515911-0 2017 Binding free energy calculations on E-selectin complexes with sLex oligosaccharide analogs. Oligosaccharides 67-82 selectin E Homo sapiens 36-46 27515911-5 2017 These results provide valuable information to increase understanding about E-selectin-oligosaccharide interactions and conduct further research aimed at designing novel ligands targeting this protein. Oligosaccharides 86-101 selectin E Homo sapiens 75-85 12678821-8 2003 Critical in generating exogenous oligosaccharides as SLe(x/a) mimetics is the stereoselective joining of specific mono- and di- saccharides that express functional groups integral in E-selectin-SLe(x/a) binding. Oligosaccharides 33-49 selectin E Homo sapiens 183-193 9861495-7 1998 In this system we have shown that the oligosaccharide moiety of AGP, as expressed in inflammatory disease, can inhibit the sLeX/E-Selectin interaction. Oligosaccharides 38-53 selectin E Homo sapiens 128-138 8872124-6 1996 The aberrant expression of these oligosaccharide structures on the HT-29 cell surface resulted in: (1) decreased E-selectin mediated adhesion of human colon cells to human umbilical cord endothelial cells (HUVEC); (2) impaired adhesion of HT-29 cells to beta-galactoside binding lectin, galectin-1; and (3) reduced ability to form homotypic aggregates. Oligosaccharides 33-48 selectin E Homo sapiens 113-123 8642261-7 1996 Depletion of lymphocyte populations or T cell clones bearing these oligosaccharides with the monoclonal antibody CSLEX-1 and HECA-452, respectively, resulted in a substantial reduction in adhesion to E-selectin and slight reduction in adhesion to P-selectin under flow conditions. Oligosaccharides 67-83 selectin E Homo sapiens 200-210 16473907-2 2006 Using this apparatus, we apply a point-like force to a vesicle that is adhered by means of specific bonds between the vesicle-carrying oligosaccharide sialyl LewisX and the surface-grafted E-selectin. Oligosaccharides 135-150 selectin E Homo sapiens 189-199 11169736-2 2001 In addition, in vitro studies have suggested that an interaction between E-selectin and binding sites such as sialyl Lewis X-containing oligosaccharides on endothelial cells may be important for angiogenesis. Oligosaccharides 136-152 selectin E Homo sapiens 73-83 10517006-0 1999 Syntheses and evaluation of biantennary oligosaccharide ligands mimicking sialyl Lewis X. Sialyl Lewis X (1) is known to be a ligand of the cell adhesion molecule E-selectin. Oligosaccharides 40-55 selectin E Homo sapiens 163-173 9033386-3 1997 The region of K3 that interacts with bound oligosaccharides superimposes closely with the corresponding region of unliganded E-selectin. Oligosaccharides 43-59 selectin E Homo sapiens 125-135 8900435-9 1996 Our data suggest that (i) protein-bound sLe(a) oligosaccharides represent only a minor portion of whole sLe(a) antigen produced by uroepithelial cells; (ii) effective binding to E-selectin occurs when sLe(a) oligosaccharide present on cell-surface glycosphingolipids is expressed in high density since the cell lines with moderate expression of sLe(a) ganglioside did not bind to E-selectin-transfected CHO cells. Oligosaccharides 47-63 selectin E Homo sapiens 178-188 8900435-9 1996 Our data suggest that (i) protein-bound sLe(a) oligosaccharides represent only a minor portion of whole sLe(a) antigen produced by uroepithelial cells; (ii) effective binding to E-selectin occurs when sLe(a) oligosaccharide present on cell-surface glycosphingolipids is expressed in high density since the cell lines with moderate expression of sLe(a) ganglioside did not bind to E-selectin-transfected CHO cells. Oligosaccharides 47-62 selectin E Homo sapiens 178-188 8544173-2 1995 A model of E-selectin/sLex binding, along with previously reported structure-activity relationships of sLex-related oligosaccharide, was used in the rational design of non-oligosaccharide inhibitors of this pivotal interaction. Oligosaccharides 116-131 selectin E Homo sapiens 11-21 8544173-2 1995 A model of E-selectin/sLex binding, along with previously reported structure-activity relationships of sLex-related oligosaccharide, was used in the rational design of non-oligosaccharide inhibitors of this pivotal interaction. Oligosaccharides 172-187 selectin E Homo sapiens 11-21 7591266-1 1995 We show here that colon-carcinoma cell lines adhere to E-selectin via sialyl Lewis x and sialyl Lewis a (s(Lex) and s(Lea)) oligosaccharides and that this adhesion can be enhanced by TNF stimulation. Oligosaccharides 124-140 selectin E Homo sapiens 55-65 7539797-9 1995 The results presented here show that an E-selectin mutant protein possessing this change displays preferential binding to mannose containing oligosaccharides and that further mutagenesis of this mannose-binding selectin confers galactose recognition in a predictable manner. Oligosaccharides 141-157 selectin E Homo sapiens 40-50 7511652-8 1994 Taken together, we provide evidence that NK cells have a di-sLe(x) oligosaccharide capable of adhesion to E-selectin, and NK cells have the machinery (i.e., relevant transferases) to generate these sialylated Lewis oligosaccharides. Oligosaccharides 67-82 selectin E Homo sapiens 106-116 7509201-1 1994 A tetrasaccharide related to the blood group oligosaccharides, known as sialyl LewisX, has been proposed as the receptor for the lectin responsible for leukocyte adhesion named alternatively as E-selectin or ELAM-1. Oligosaccharides 45-61 selectin E Homo sapiens 208-214 8104998-4 1993 As we have shown previously, NCA-160 and NCA-90 present sialylated Lewis-X oligosaccharide Ag (SLex) in a functional way, i.e., these Ag function as (one of many possible) molecules involved in neutrophil binding to the adhesion molecule E-selectin expressed on activated endothelial cells. Oligosaccharides 75-90 selectin E Homo sapiens 238-248 1382586-3 1992 This report is concerned with identification of a new class of oligosaccharide ligand--sulfate-containing--for the human E-selectin molecule from among oligosaccharides on an ovarian cystadenoma glycoprotein. Oligosaccharides 63-78 selectin E Homo sapiens 121-131 7680663-0 1993 Higher-affinity oligosaccharide ligands for E-selectin. Oligosaccharides 16-31 selectin E Homo sapiens 44-54 7680663-8 1993 IC50 values of soluble oligosaccharides determined in competitive binding studies accurately predicted blocking of leukocyte adhesion to recombinant E-selectin-Ig and to cytokine-activated endothelium. Oligosaccharides 23-39 selectin E Homo sapiens 149-159 1382586-3 1992 This report is concerned with identification of a new class of oligosaccharide ligand--sulfate-containing--for the human E-selectin molecule from among oligosaccharides on an ovarian cystadenoma glycoprotein. Oligosaccharides 152-168 selectin E Homo sapiens 121-131 1382586-5 1992 Oligosaccharides were conjugated to lipid, resolved by thin-layer chromatography, and tested for binding by Chinese hamster ovary cells which had been transfected to express the full-length E-selectin molecule. Oligosaccharides 0-16 selectin E Homo sapiens 190-200 1382586-6 1992 Several components with strong E-selectin binding activity were revealed among acidic oligosaccharides. Oligosaccharides 86-102 selectin E Homo sapiens 31-41 1378450-14 1992 Together, these findings indicate that the CD66 antigens (i.e., NCA-160/NCA-90) function as presenter molecules of the SLe(x) oligosaccharide structures on neutrophils that bind to ELAM-1 on EC. Oligosaccharides 126-141 selectin E Homo sapiens 181-187 1377689-2 1992 Carbohydrate recognition by the human endothelial-leukocyte adhesion molecule, E-selectin, has been investigated by binding studies using 3H-labeled Chinese hamster ovary cells expressing different levels of the transfected full-length adhesion molecule and a series of structurally defined oligosaccharides linked to the lipid phosphatidylethanolamine dipalmitoate (neoglycolipids) and synthetic glycolipids chromatographed on silica gel plates or immobilized on plastic wells. Oligosaccharides 291-307 selectin E Homo sapiens 79-89 1716630-5 1991 In Chinese hamster ovary cells, however, the enzyme can determine expression of the alpha 2----3-sialylated, alpha 1----3-fucosylated structure known as VIM-2, a putative oligosaccharide ligand for ELAM-1. Oligosaccharides 171-186 selectin E Homo sapiens 198-204