PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 10862685-1 2000 A new easily scalable approach to the recovery of biologically active oligosaccharides from milk has been developed which relies on the combination of enzymatic treatment of defatted milk using beta-galactosidase and nanofiltration. Oligosaccharides 70-86 galactosidase beta 1 Homo sapiens 194-212 11550799-1 2001 Lysosomal enzymes sialidase (alpha-neuraminidase), beta-galactosidase, and N-acetylaminogalacto-6-sulfate sulfatase are involved in the catabolism of glycolipids, glycoproteins, and oligosaccharides. Oligosaccharides 182-198 galactosidase beta 1 Homo sapiens 51-69 10230039-0 1998 alpha-D-Glcp-(1<-->1)-beta-D-Galp-containing oligosaccharides, novel products from lactose by the action of beta-galactosidase. Oligosaccharides 51-67 galactosidase beta 1 Homo sapiens 114-132 10230039-1 1998 A mixture of oligosaccharides produced by beta-galactosidase using lactose as a substrate was fractionated according to degree of polymerization using gel filtration, followed by high-pH anion-exchange chromatography. Oligosaccharides 13-29 galactosidase beta 1 Homo sapiens 42-60 7737204-4 1995 When necessary, oligosaccharides were treated with endo-beta-galactosidase (and N-acetyl-beta-glucosaminidase) followed by 1H-NMR analysis of the incubation products, to obtain additional structural information. Oligosaccharides 16-32 galactosidase beta 1 Homo sapiens 56-74 10052590-3 1998 By treatment of this oligosaccharide with neuraminidase and beta-galactosidase, we readily obtained an asialo-agalacto-biantennary heptasaccharide (GlcNAcbeta 1,2Manalpha1,6[GlcNAcbeta1,2Manalpha1,3]Manbeta1 ,4GlcNAcbeta1,4GlcNAc). Oligosaccharides 21-36 galactosidase beta 1 Homo sapiens 60-78 9242510-0 1997 CD44 substituted with heparan sulfate and endo-beta-galactosidase-sensitive oligosaccharides: a major proteoglycan in adult human epidermis. Oligosaccharides 76-92 galactosidase beta 1 Homo sapiens 47-65 9242510-8 1997 Five to 33% of 35SO4 and 26-37% of [3H]glucosamine, however, was released by endo-beta-galactosidase, implying marked substitution by oligosaccharides with N-acetyllactosamine repeats. Oligosaccharides 134-150 galactosidase beta 1 Homo sapiens 82-100 9242510-14 1997 Both the large and the 100-kDa variant of epidermal CD44 contain endo-beta-galactosidase-sensitive oligosaccharides not previously noted in other cells or tissues. Oligosaccharides 99-115 galactosidase beta 1 Homo sapiens 70-88 7737204-9 1995 Tetraantennary oligosaccharides with N-acetyllactosamine repeats could be digested quantitatively with endo-beta-galactosidase from Bacteroides fragilis, whereas under the same conditions tri" antennary oligosaccharides hardly reacted (< 15%). Oligosaccharides 15-31 galactosidase beta 1 Homo sapiens 108-126 7881170-7 1994 Treatment of total first-trimester cytotrophoblast beta 1 integrins or the isolated alpha 5/beta 1 fibronectin receptor with endo-beta-galactosidase restored electrophoretic mobility to control levels, suggesting the presence of polylactosamine-bearing oligosaccharides. Oligosaccharides 253-269 galactosidase beta 1 Homo sapiens 130-148 1904815-6 1991 The method was applied to the analysis of the partial sequential degradation of a complex oligosaccharide with neuraminidase and beta-galactosidase. Oligosaccharides 90-105 galactosidase beta 1 Homo sapiens 129-147 8434801-7 1993 The other 24 oligosaccharides were derived by subsequent digestion of the 16 original oligosaccharides with beta-galactosidase or alpha-fucosidase. Oligosaccharides 13-29 galactosidase beta 1 Homo sapiens 108-126 1907570-2 1991 Tetraantennary oligosaccharides containing extra N-acetyllactosamine units were digested with endo-beta-galactosidase, followed by treatment with N-acetyl-beta-glucosaminidase, yielding products which could be analysed by 1H-NMR spectroscopy, thereby giving conclusive data about the location of the extra units in the intact structures. Oligosaccharides 15-31 galactosidase beta 1 Homo sapiens 99-117 7521878-9 1994 Endo-beta-galactosidase-treated PSGL-1 retained the ability to bind to P-selectin, suggesting that some of the oligosaccharides recognized by P-selectin were either on enzyme-resistant poly-N-acetyllactosamine or on chains which lack poly-N-acetyllactosamine. Oligosaccharides 111-127 galactosidase beta 1 Homo sapiens 5-23 8168537-9 1994 Analysis of the endo-beta-galactosidase digests of pools of N- and O-glycans indicated that the two types of oligosaccharides contain qualitatively similar poly(N-acetyllactosamine) chains. Oligosaccharides 109-125 galactosidase beta 1 Homo sapiens 21-39 1378838-7 1992 Endo-beta-galactosidase and neuraminidase destroyed the activity of the oligosaccharides, but alpha-L-fucosidase did not. Oligosaccharides 72-88 galactosidase beta 1 Homo sapiens 5-23 1991474-9 1991 Treatment with beta-galactosidase, beta-N-acetylglucosaminidase and alpha-mannosidase resulted in a decrease of the oligosaccharide elution times corresponding to the number of sugar residues lost, the profile of changes was highly reproducible. Oligosaccharides 116-131 galactosidase beta 1 Homo sapiens 15-33 2808357-6 1989 Structures of the oligosaccharides were estimated from the data of the binding specificities of immobilized lectin columns and the effective size of each oligosaccharide determined by passing through a Bio-Gel P-4 column and were then confirmed by endo-beta-galactosidase digestion, sequential digestion with exoglycosidases with different aglycon specificities, and methylation analysis. Oligosaccharides 18-34 galactosidase beta 1 Homo sapiens 253-271 2243102-5 1990 The poly-N-acetyllactosaminyl structures of isolated glycopeptides were confirmed by the susceptibility of their released oligosaccharides to endo-beta-galactosidase. Oligosaccharides 122-138 galactosidase beta 1 Homo sapiens 147-165 2504311-5 1989 In addition, differences were noted in the activity of beta-galactosidase toward oligosaccharides having the Gal beta(1----3)GlcNAc or Gal beta(1----4)GlcNAc structure at reducing termini. Oligosaccharides 81-97 galactosidase beta 1 Homo sapiens 55-73 2475168-3 1989 However, after treatment with chondroitinase ABC followed by endo-beta-galactosidase, several proteoglycan species showed HNK-1 reactivity, presumably due to the presence of this epitope on other oligosaccharides which are both resistant to endo-beta-galactosidase and inaccessible to the antibody in the native proteoglycan. Oligosaccharides 196-212 galactosidase beta 1 Homo sapiens 66-84 3379051-15 1988 About 30% of the 35S-labeled oligosaccharides from CPAE were sensitive to endo-beta-galactosidase, indicating that poly-N-acetyl-lactosamine structures were present on some chains. Oligosaccharides 29-45 galactosidase beta 1 Homo sapiens 79-97 18581545-1 1987 Enzymatic lactose hydrolysis by beta-galactosidase (lactase) was investigated with respect to the formation of oligosaccharides. Oligosaccharides 111-127 galactosidase beta 1 Homo sapiens 32-50 3360793-5 1988 The oligosaccharide of GM1 and deacetyl-fatty acid free GM1 (II3-NeuGg-Ose4-sphingosine) were hydrolyzed by beta-galactosidase in the absence of this activator protein. Oligosaccharides 4-19 galactosidase beta 1 Homo sapiens 108-126 3147610-0 1988 Lactose hydrolysis and oligosaccharide formation catalyzed by beta-galactosidase. Oligosaccharides 23-38 galactosidase beta 1 Homo sapiens 62-80 3128279-1 1988 of oligosaccharides of N-acetyl-lactosamine-type released from human erythrocyte glycopeptides by endo-beta-galactosidase. Oligosaccharides 3-19 galactosidase beta 1 Homo sapiens 103-121 3128279-3 1988 spectroscopy has been used in structural studies of three linear and five branched oligosaccharides of N-acetyl-lactosamine-type that were released from desialylated blood group O erythrocyte glycopeptides by treatment with the endo-beta-galactosidase of Bacteroides fragilis followed by reduction. Oligosaccharides 83-99 galactosidase beta 1 Homo sapiens 233-251 3609611-2 1987 The oligosaccharide chains of this enzyme were enzymatically removed with various glycosidic enzymes (endoglycosidases D, F, and H; glycopeptidase F; alpha-mannosidase; neuraminidase; and beta-galactosidase). Oligosaccharides 4-19 galactosidase beta 1 Homo sapiens 188-206 3117549-0 1987 Characterisation of oligosaccharides released from human-blood-group O erythrocyte glycopeptides by the endo-beta-galactosidase of Bacteroides fragilis. Oligosaccharides 20-36 galactosidase beta 1 Homo sapiens 109-127 2959666-10 1987 Biochemical analysis of the internalized ligands indicates that: (a) the subunit molecular mass of both beta-glucuronidase and beta-galactosidase decrease upon cell association relative to the input form of the enzymes, and (b) the beta-glucuronidase molecules experience a limited dephosphorylation such that high-mannose-type oligosaccharides containing two phosphomonoesters are converted to single phosphomonoester forms. Oligosaccharides 328-344 galactosidase beta 1 Homo sapiens 127-145 2430799-2 1986 Conditions were established for desulphation of hexa-, octa-, deca- and larger oligosaccharides derived from corneal keratan sulphate after treatment with endo-beta-galactosidase. Oligosaccharides 79-95 galactosidase beta 1 Homo sapiens 160-178 6774338-5 1980 The profiles of oligosaccharides released by endo-beta-galactosidase and immunofluorescence studies with anti-Ii antibodies indicated that a linear polylactosaminoglycan structure was present in erythroblasts as well as in erythrocytes of the fetal and newborn stage, whereas a branched polylactosaminoglycan structure was present in erythroblasts as well as erythrocytes of adult blood. Oligosaccharides 16-32 galactosidase beta 1 Homo sapiens 50-68 3100590-0 1986 Effect of various conditions on the formation of oligosaccharides in milk treated with beta-galactosidase. Oligosaccharides 49-65 galactosidase beta 1 Homo sapiens 87-105 3084467-5 1986 The oligosaccharide profiles produced from various keratan sulfates and erythroglycan by the action of urinary endo-beta-galactosidase are quite similar to those produced by Escherichia freundii endo-beta-galactosidase (Nakagawa, H., Yamada, T., Chien, J.-L., Gardas, A., Kitamikado, M., Li, S.-C., and Li, Y.-T. (1980) J. Biol. Oligosaccharides 4-19 galactosidase beta 1 Homo sapiens 116-134 3084467-5 1986 The oligosaccharide profiles produced from various keratan sulfates and erythroglycan by the action of urinary endo-beta-galactosidase are quite similar to those produced by Escherichia freundii endo-beta-galactosidase (Nakagawa, H., Yamada, T., Chien, J.-L., Gardas, A., Kitamikado, M., Li, S.-C., and Li, Y.-T. (1980) J. Biol. Oligosaccharides 4-19 galactosidase beta 1 Homo sapiens 200-218 3005249-5 1985 It was found that these sugar chains comprise about 40% of total alkali-labile oligosaccharides of asialo GP-2 and contain endo-beta-galactosidase (Flavobacterium keratolyticus)-resistant highly branched and heterogeneous oligosaccharides of poly-N-acetyllactosamine type which are linked O-glycosidically to the peptide backbone through N-acetylgalactosamine. Oligosaccharides 222-238 galactosidase beta 1 Homo sapiens 128-146 6094178-9 1984 Chromatography of the oligosaccharides on Bio-Gel P6 and Concanavalin A columns indicated a spectrum of oligosaccharides which include those of high mannose type labelled with [3H]glucosamine, and a mixture of oligosaccharides labelled with [3H]fucose and [3H]glucosamine of bi- and multiantennary complex types of which a subpopulation is susceptible to digestion with endo-beta-galactosidase. Oligosaccharides 22-38 galactosidase beta 1 Homo sapiens 375-393 6790542-4 1981 All these 95 oligosaccharides contain Gal beta 1 leads to 4GlcNAc beta 1 lead to 3 repeating structures in their outer chain moieties, indicating that the tissues of GM1-gangliosidosis Type 2 patients do contain beta-galactosidase activity which releases readily galactose residue from such repeating sugar chains. Oligosaccharides 13-29 galactosidase beta 1 Homo sapiens 212-230 7213594-10 1981 Retention by concanavalin A-Sepharose was observed only after treatment of the oligosaccharide with beta-galactosidase. Oligosaccharides 79-94 galactosidase beta 1 Homo sapiens 100-118 7188422-9 1980 Most of these oligosaccharides were digested with a mixture of beta-galactosidase and beta-N-acetylhexosaminidase after alpha-L-fucosidase treatment to give a small oligosaccharide with the structure alpha Man2-beta Man-beta GlcNAc-GlcNAc. Oligosaccharides 14-30 galactosidase beta 1 Homo sapiens 63-81 7188422-9 1980 Most of these oligosaccharides were digested with a mixture of beta-galactosidase and beta-N-acetylhexosaminidase after alpha-L-fucosidase treatment to give a small oligosaccharide with the structure alpha Man2-beta Man-beta GlcNAc-GlcNAc. Oligosaccharides 14-29 galactosidase beta 1 Homo sapiens 63-81 3003205-6 1986 Effects of beta-galactosidase were reversed by readdition of galactose to cell-surface oligosaccharide acceptors. Oligosaccharides 87-102 galactosidase beta 1 Homo sapiens 11-29 6431970-5 1984 It could be converted to a sharper band (apparent Mr 23000) by treatment with endo-beta-galactosidase from Bacteroides fragilis and so probably contains one or more sites at which an oligosaccharide of the poly(N-acetyl-lactosamine) type is attached. Oligosaccharides 183-198 galactosidase beta 1 Homo sapiens 83-101 4796096-0 1973 Formation of oligosaccharides during beta-galactosidase action on lactose. Oligosaccharides 13-29 galactosidase beta 1 Homo sapiens 37-55 99449-0 1978 Release of oligosaccharides from various glycosphingolipids by endo-beta-galactosidase. Oligosaccharides 11-27 galactosidase beta 1 Homo sapiens 68-86 31260766-0 2019 Oligosaccharides act as the high efficiency stabilizer for beta-galactosidase under heat treatment. Oligosaccharides 0-16 galactosidase beta 1 Homo sapiens 59-77 31494342-7 2020 This article reviews the main applications of beta-galactosidase, going from its conventional use related to its hydrolytic activity to the ongoing non-conventional applications in the synthesis of high added-value oligosaccharides based on its transgalactosylation activity. Oligosaccharides 215-231 galactosidase beta 1 Homo sapiens 46-64 31260766-2 2019 This study investigated the ability of oligosaccharides to protect beta-Gal against heat stress. Oligosaccharides 39-55 galactosidase beta 1 Homo sapiens 67-75 31260766-4 2019 The results of three assays including circular dichroism, fluorescence, and Fourier transform infrared spectroscopy (FTIR) illustrated that these oligosaccharides could stabilize the secondary and tertiary structure of beta-Gal under thermal conditions through hydrogen bond interaction. Oligosaccharides 146-162 galactosidase beta 1 Homo sapiens 219-227 25964111-2 2015 Using this compound, we developed highly sensitive fluorescence-based high-throughput assays for both endo-beta-galactosidase and alpha-N-acetylgalactosaminidase activity specific for the oligosaccharide structure of the blood group A antigen. Oligosaccharides 188-203 galactosidase beta 1 Homo sapiens 107-125 28193420-1 2017 beta-Galactosidase enzymes are used in the dairy industry to convert lactose into galactooligosaccharides (GOS) that are added to infant formula to mimic the molecular sizes and prebiotic functions of human milk oligosaccharides. Oligosaccharides 89-105 galactosidase beta 1 Homo sapiens 0-18 30270003-4 2018 Based on these results and on docking studies, the 5-C-pentyl derivative 1 was selected as the optimal structure for further investigations: this compound induces the maturation of mutated beta-galactosidase in fibroblasts of a GM1-gangliosidosis patient and promote the decrease of keratan sulfate and oligosaccharide load in patient cells. Oligosaccharides 303-318 galactosidase beta 1 Homo sapiens 189-207 25647617-6 2015 beta-Galactosidase and beta-N-acetylhexosaminidase were used to convert complex oligosaccharides into two peaks containing either GlcNAc2Man3Fuc or GlcNAc2Man3, which simplified the chromatograms and data analysis. Oligosaccharides 80-96 galactosidase beta 1 Homo sapiens 0-18 25647617-7 2015 More importantly, low abundance hybrid oligosaccharides can only be detected and qualified after beta-galactosidase and beta-N-acetylhexosaminidase digestion. Oligosaccharides 39-55 galactosidase beta 1 Homo sapiens 97-115 22367946-0 2012 A selected probiotic strain of Lactobacillus fermentum CM33 isolated from breast-fed infants as a potential source of beta-galactosidase for prebiotic oligosaccharide synthesis. Oligosaccharides 151-166 galactosidase beta 1 Homo sapiens 118-136 24909380-1 2015 Recombinant alpha- and beta-galactosidases could be prepared in larger amounts for chemoenzymatic syntheses of glycosylated oligosaccharides relevant in nutrition approaches. Oligosaccharides 124-140 galactosidase beta 1 Homo sapiens 12-42 22367946-6 2012 A preliminary study on the enzymatic synthesis of oligosaccharide using crude beta-galactosidase revealed the capability for oligosaccharide synthesis by the transgalactosylation activity. Oligosaccharides 50-65 galactosidase beta 1 Homo sapiens 78-96 22367946-6 2012 A preliminary study on the enzymatic synthesis of oligosaccharide using crude beta-galactosidase revealed the capability for oligosaccharide synthesis by the transgalactosylation activity. Oligosaccharides 125-140 galactosidase beta 1 Homo sapiens 78-96 15850798-4 2005 Treatment of Intestine-407 cells with neuraminidase led to a significant increase in the binding of type A PTX, while further digestion of cell surface oligosaccharides by beta-galactosidase and beta-N-acetylhexosaminidase decreased the binding. Oligosaccharides 152-168 galactosidase beta 1 Homo sapiens 172-190