PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 16434617-5 2006 Instead, merbarone induced rapid activation of the mitochondrial apoptosis pathway, which included the following temporal sequence of events: dissipation of the mitochondrial transmembrane potential within 30 min, release of mitochondrial cytochrome c, and activation of caspase-activated DNase (CAD) by its inhibitor ICAD. merbarone 9-18 DNA fragmentation factor subunit alpha Homo sapiens 318-322 16434617-6 2006 The excision of high molecular weight DNA was inhibited at least 80% in merbarone-treated cells preincubated with the pan-caspase inhibitor z-VAD-fmk [Z-Val-Ala-Asp(OMe)-fluoromethyl ketone] and in caspase-resistant Jurkat cells (ICAD/double-mutated) that express a mutant form of ICAD. merbarone 72-81 DNA fragmentation factor subunit alpha Homo sapiens 230-234 16434617-6 2006 The excision of high molecular weight DNA was inhibited at least 80% in merbarone-treated cells preincubated with the pan-caspase inhibitor z-VAD-fmk [Z-Val-Ala-Asp(OMe)-fluoromethyl ketone] and in caspase-resistant Jurkat cells (ICAD/double-mutated) that express a mutant form of ICAD. merbarone 72-81 DNA fragmentation factor subunit alpha Homo sapiens 281-285