PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
10474772-6	1999	In vitro, human erythrocyte acetylcholinesterase (AChE) hydrolyses heroin to 6-MAM, with a catalytic efficiency of 0.5/min per mumol/L under first-order kinetics.	Heroin	67-73	acetylcholinesterase (Cartwright blood group)	Homo sapiens	28-48	
10474772-0	1999	Human erythrocyte but not brain acetylcholinesterase hydrolyses heroin to morphine.	Heroin	64-70	acetylcholinesterase (Cartwright blood group)	Homo sapiens	32-52	
10474772-6	1999	In vitro, human erythrocyte acetylcholinesterase (AChE) hydrolyses heroin to 6-MAM, with a catalytic efficiency of 0.5/min per mumol/L under first-order kinetics.	Heroin	67-73	acetylcholinesterase (Cartwright blood group)	Homo sapiens	50-54	
30080993-5	2018	Here we report the kinetic characterization of AChE, BChE, and a therapeutically promising cocaine hydrolase (CocH1) for heroin and 6-MAM hydrolyses under the same experimental conditions.	Heroin	121-127	acetylcholinesterase (Cartwright blood group)	Homo sapiens	47-51	
30080993-3	2018	It has been known that heroin hydrolysis to 6-MAM and morphine is accelerated by cholinesterases, including acetylcholinesterase (AChE) and/or butyrylcholinesterase (BChE).	Heroin	23-29	acetylcholinesterase (Cartwright blood group)	Homo sapiens	108-128	
30080993-3	2018	It has been known that heroin hydrolysis to 6-MAM and morphine is accelerated by cholinesterases, including acetylcholinesterase (AChE) and/or butyrylcholinesterase (BChE).	Heroin	23-29	acetylcholinesterase (Cartwright blood group)	Homo sapiens	130-134	
30080993-6	2018	It has been demonstrated that AChE and BChE have similar kcat values (2100 and 1840 min-1, respectively) against heroin, but with a large difference in KM (2170 and 120 muM, respectively).	Heroin	113-119	acetylcholinesterase (Cartwright blood group)	Homo sapiens	30-34	
30080993-7	2018	Both AChE and BChE can catalyze 6-MAM hydrolysis to morphine, with relatively lower catalytic efficiency compared to the heroin hydrolysis.	Heroin	121-127	acetylcholinesterase (Cartwright blood group)	Homo sapiens	5-9	
20641589-15	2004	The esterase activity of BChE plays an important role in scavenging anti-AChE compounds such as cocaine, heroin, and organophosphate before they reach AChE at physiologically important sites.	Heroin	105-111	acetylcholinesterase (Cartwright blood group)	Homo sapiens	73-77	
20641640-15	2004	The esterase activity of BChE plays an important role in scavenging anti-AChE compounds such as cocaine, heroin, and organophosphate before they reach AChE at physiologically important sites.	Heroin	105-111	acetylcholinesterase (Cartwright blood group)	Homo sapiens	73-77