PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 34476566-4 2021 In the present study, we detected the DNA methylation in the promoter regions of five representative dopaminergic system genes (DRD1, DRD2, SLC6A3, TH, and COMT) between 120 patients with heroin use disorder in methadone maintenance treatment (MMT) program and 111 healthy controls. Heroin 188-194 catechol-O-methyltransferase Homo sapiens 156-160 12673581-1 2003 OBJECTIVE: To detect the relationship between heroin dependence and catechol-O-methyltransferase (COMT) gene. Heroin 46-52 catechol-O-methyltransferase Homo sapiens 68-96 12673581-1 2003 OBJECTIVE: To detect the relationship between heroin dependence and catechol-O-methyltransferase (COMT) gene. Heroin 46-52 catechol-O-methyltransferase Homo sapiens 98-102 12673581-2 2003 METHODS: Genotype and allele frequencies of 108 val/met and 900 Ins C/Del C polymorphisms of COMT gene were examined in 313 heroin-dependent subjects and 214 normal controls. Heroin 124-130 catechol-O-methyltransferase Homo sapiens 93-97 12476424-1 2002 OBJECTIVE: To detect the relationship between heroin-dependence and -287 A/G polymorphism of catechol-O-methyltransferase(COMT) gene. Heroin 46-52 catechol-O-methyltransferase Homo sapiens 93-121 12476424-1 2002 OBJECTIVE: To detect the relationship between heroin-dependence and -287 A/G polymorphism of catechol-O-methyltransferase(COMT) gene. Heroin 46-52 catechol-O-methyltransferase Homo sapiens 122-126 12476424-2 2002 METHODS: Genotype and allele frequencies of -287 A/G polymorphism of COMT gene were examined in 268 heroin-dependent subjects and 177 normal controls. Heroin 100-106 catechol-O-methyltransferase Homo sapiens 69-73 12476424-3 2002 RESULTS: Weak but significant difference in genotype of -287 A/G polymorphism of COMT gene was observed between heroin-dependent subjects and controls (chi(2)=7.41, P=0.025), and genotype AA was higher in the former. Heroin 112-118 catechol-O-methyltransferase Homo sapiens 81-85 12476424-4 2002 The frequency of allele A of -287 A/G polymorphism of COMT gene was also significantly higher in heroin-dependent subjects than in the controls (chi(2)=5.69, P=0.017). Heroin 97-103 catechol-O-methyltransferase Homo sapiens 54-58 23840506-4 2013 METHODS: 303 heroin dependent subjects and 555 healthy controls were genotyped for 7 single nucleotide polymorphisms (SNPs) rs4680 of the COMT gene; rs1079597 and rs1800498 of the DRD2 gene; rs1800497 of the ANKK1 gene; rs1800955, rs936462 and rs747302 of the DRD4 gene. Heroin 13-19 catechol-O-methyltransferase Homo sapiens 138-142 33577997-0 2021 Association Study of Catechol-O-methyltransferase and Alpha-1-adrenergic Receptor Gene Polymorphisms with Multiple Phenotypes of Heroin Use Disorder. Heroin 129-135 catechol-O-methyltransferase Homo sapiens 21-49 33577997-3 2021 Single-nucleotide polymorphisms (SNPs) of catechol-O-methyltransferase (COMT) and alpha-1-adrenergic receptor (ADRA1A) genes are associated with heroin use disorder. Heroin 145-151 catechol-O-methyltransferase Homo sapiens 42-70 33577997-3 2021 Single-nucleotide polymorphisms (SNPs) of catechol-O-methyltransferase (COMT) and alpha-1-adrenergic receptor (ADRA1A) genes are associated with heroin use disorder. Heroin 145-151 catechol-O-methyltransferase Homo sapiens 72-76 33577997-9 2021 Subjects with the G allele of COMT rs769224 were more likely to take a higher dose of heroin every day. Heroin 86-92 catechol-O-methyltransferase Homo sapiens 30-34 33577997-10 2021 Our study confirmed the association between polymorphisms of COMT and ADRA1A with those specific phenotypes of heroin use disorder, which will be instructive for the precise treatment of the disease. Heroin 111-117 catechol-O-methyltransferase Homo sapiens 61-65 33544778-11 2021 Further, it was found that Met/Met containing variants of COMT polymorphism has a more extended period of addiction than other genetic variants in heroin abused subjects. Heroin 147-153 catechol-O-methyltransferase Homo sapiens 58-62 26345603-2 2015 The aim of this study was to evaluate the effect of personality traits, impulsivity, and COMT gene polymorphism (rs4680) on relapse to heroin use during 5-year follow up. Heroin 135-141 catechol-O-methyltransferase Homo sapiens 89-93 23155402-0 2012 Pathways to age of onset of heroin use: a structural model approach exploring the relationship of the COMT gene, impulsivity and childhood trauma. Heroin 28-34 catechol-O-methyltransferase Homo sapiens 102-106 23155402-5 2012 The single nucleotide polymorphism (SNP) rs737866 on the COMT gene-which has previously been associated with heroin abuse, was genotyped using a DNA sequence detection system. Heroin 109-115 catechol-O-methyltransferase Homo sapiens 57-61 23155402-9 2012 In structure equation model, both the COMT gene and childhood trauma had impacts on the age of onset of heroin use directly or via impulsive personality. Heroin 104-110 catechol-O-methyltransferase Homo sapiens 38-42 23155402-10 2012 CONCLUSIONS: Our findings indicated that the COMT gene, impulsive personality traits and childhood trauma experience were interacted to impact the age of onset of heroin use, which play a critical role in the development of heroin dependence. Heroin 163-169 catechol-O-methyltransferase Homo sapiens 45-49 21857968-0 2011 Role of novelty seeking personality traits as mediator of the association between COMT and onset age of drug use in Chinese heroin dependent patients. Heroin 124-130 catechol-O-methyltransferase Homo sapiens 82-86 21857968-3 2011 OBJECTIVE: Examine the relationships between allelic variants of the catechol-O-methyltransferase (COMT) gene, NS personality traits, and age of onset of drug use in heroin-dependent subjects in China. Heroin 166-172 catechol-O-methyltransferase Homo sapiens 69-97 21857968-3 2011 OBJECTIVE: Examine the relationships between allelic variants of the catechol-O-methyltransferase (COMT) gene, NS personality traits, and age of onset of drug use in heroin-dependent subjects in China. Heroin 166-172 catechol-O-methyltransferase Homo sapiens 99-103 20517217-0 2010 [Association study of the Val158Met polymorphism of the catechol-O-methyltransferase gene and alcoholism and heroin dependence: the role of a family history]. Heroin 109-115 catechol-O-methyltransferase Homo sapiens 56-84 20728009-7 2010 CONCLUSION: Association of the COMT polymorphism and NS temperament scale has been shown for heroin-dependent patients and controls regardless of group status. Heroin 93-99 catechol-O-methyltransferase Homo sapiens 31-35 19827317-4 2009 In connection with the development of heroin addiction the role of the dopamine D2 and D4 receptors, the dopamine transporter and the catechol-O-methyltransferase genes is discussed. Heroin 38-44 catechol-O-methyltransferase Homo sapiens 134-162 19259017-3 2008 A functional polymorphism (COMT Val158Met) resulting in increased enzyme activity has been associated with polysubstance abuse and addiction to heroin and methamphetamine. Heroin 144-150 catechol-O-methyltransferase Homo sapiens 27-31