PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
20649590-1	2010	BACKGROUND AND PURPOSE: Carboxylesterases (CEs) metabolize a wide range of xenobiotic substrates including heroin, cocaine, meperidine and the anticancer agent CPT-11.	Heroin	107-113	carboxylesterase 1	Homo sapiens	24-41	
12773168-2	2003	hCE1 catalyses the hydrolysis of heroin and cocaine, and the transesterification of cocaine in the presence of ethanol to the toxic metabolite cocaethylene.	Heroin	33-39	carboxylesterase 1	Homo sapiens	0-4	
12679808-2	2003	Human carboxylesterase 1 (hCE1) is a broad-spectrum bioscavenger that catalyzes the hydrolysis of heroin and cocaine, and the detoxification of organophosphate chemical weapons, such as sarin, soman and tabun.	Heroin	98-104	carboxylesterase 1	Homo sapiens	6-24	
12679808-2	2003	Human carboxylesterase 1 (hCE1) is a broad-spectrum bioscavenger that catalyzes the hydrolysis of heroin and cocaine, and the detoxification of organophosphate chemical weapons, such as sarin, soman and tabun.	Heroin	98-104	carboxylesterase 1	Homo sapiens	26-30	
12679808-3	2003	Crystal structures of the hCE1 glycoprotein in complex with the cocaine analog homatropine and the heroin analog naloxone provide explicit details about narcotic metabolism in humans.	Heroin	99-105	carboxylesterase 1	Homo sapiens	26-30	
9311626-0	1997	Human liver carboxylesterase hCE-1: binding specificity for cocaine, heroin, and their metabolites and analogs.	Heroin	69-75	carboxylesterase 1	Homo sapiens	29-34	
9311626-1	1997	Purified human liver carboxylesterase (hCE-1) catalyzes the hydrolysis of cocaine to form benzoylecgonine, the deacetylation of heroin to form 6-acetylmorphine, and the ethanol-dependent transesterification of cocaine to form cocaethylene.	Heroin	128-134	carboxylesterase 1	Homo sapiens	39-44	
9311626-2	1997	In this study, the binding affinities of cocaine, cocaine metabolites and analogs, heroin, morphine, and 6-acetylmorphine for hCE-1 were evaluated by measuring their kinetic inhibition constants with 4-methylumbelliferyl acetate in a rapid spectrophotometric assay.	Heroin	83-89	carboxylesterase 1	Homo sapiens	126-131	
8930175-0	1996	Metabolism of cocaine and heroin is catalyzed by the same human liver carboxylesterases.	Heroin	26-32	carboxylesterase 1	Homo sapiens	70-87	
8930175-12	1996	Cocaine competitively inhibited hCE-1-, hCE-2- and pseudocholinesterase-catalyzed hydrolysis of heroin to 6-monoacetylmorphine (Ki = 530, 460 and 130 microM, respectively) and 6-monoacetylmorphine hydrolysis to morphine (Ki = 710, 220 and 830 microM, respectively).	Heroin	96-102	carboxylesterase 1	Homo sapiens	32-37	
8930175-7	1996	This investigation examined the relative catalytic efficiencies of hCE-1, hCE-2 and pseudocholinesterase for heroin metabolism and compared them with cocaine hydrolysis.	Heroin	109-115	carboxylesterase 1	Homo sapiens	67-72	
8930175-9	1996	All three enzymes rapidly catalyzed hydrolysis of heroin to 6-monoacetylmorphine (hCE-1 kcat = 439 min-1, hCE-2 kcat = 2186 min-1 and pseudocholinesterase kcat = 13 min-1).	Heroin	50-56	carboxylesterase 1	Homo sapiens	82-87	
31837295-5	2020	In this study, we sought to determine the contribution of the major hepatic hydrolase carboxylesterase 1 (CES1) to heroin metabolism in the liver as well as the potential influence of one of its known genetic variants, G143E (rs71647871).	Heroin	115-121	carboxylesterase 1	Homo sapiens	86-104	
31837295-5	2020	In this study, we sought to determine the contribution of the major hepatic hydrolase carboxylesterase 1 (CES1) to heroin metabolism in the liver as well as the potential influence of one of its known genetic variants, G143E (rs71647871).	Heroin	115-121	carboxylesterase 1	Homo sapiens	106-110	
31837295-8	2020	The contribution of CES1 to the hydrolysis of heroin to 6-MAM was determined as 3.66%, and CES1 was unable to further catalyze 6-MAM under our assay conditions.	Heroin	46-52	carboxylesterase 1	Homo sapiens	20-24	
31837295-11	2020	Our study results suggested only minor involvement of CES1 in heroin hydrolysis in the liver.	Heroin	62-68	carboxylesterase 1	Homo sapiens	54-58	
31837295-0	2020	The influence of carboxylesterase 1 polymorphism and cannabidiol on the hepatic metabolism of heroin.	Heroin	94-100	carboxylesterase 1	Homo sapiens	17-35