PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 20800622-4 2011 The aim of this work was to evaluate if etoposide induces upregulation of ADAM10 or TACE/ADAM17 in two cell lines (GC-1 and GC-2) derived from male germ cells. Etoposide 40-49 olfactomedin 4 Homo sapiens 115-119 20800622-5 2011 Results showed that etoposide induced apoptosis in a dose-response manner in both GC-1 and GC-2 cells. Etoposide 20-29 olfactomedin 4 Homo sapiens 82-86 20800622-7 2011 Protein and mRNA levels of ADAM10 and TACE/ADAM17 increased 18h after etoposide was removed from the GC-1 cells. Etoposide 70-79 olfactomedin 4 Homo sapiens 101-105 20800622-10 2011 Finally, apoptosis was prevented in GC-1 and GC-2 cells by the addition of pharmacological inhibitors of ADAM10 and TACE/ADAM17 to the culture medium of etoposide-treated cells. Etoposide 153-162 olfactomedin 4 Homo sapiens 36-40