PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
18813358-0	2008	Plasminogen activator inhibitor 1 protects fibrosarcoma cells from etoposide-induced apoptosis through activation of the PI3K/Akt cell survival pathway.	Etoposide	67-76	serine (or cysteine) peptidase inhibitor, clade E, member 1	Mus musculus	0-33	
18813358-6	2008	More importantly, reintroduction of PAI-1 expression in PAI-1-deficient cells induced an increase in Akt activity and protection against etoposide-induced apoptosis.	Etoposide	137-146	serine (or cysteine) peptidase inhibitor, clade E, member 1	Mus musculus	36-41	
18813358-6	2008	More importantly, reintroduction of PAI-1 expression in PAI-1-deficient cells induced an increase in Akt activity and protection against etoposide-induced apoptosis.	Etoposide	137-146	serine (or cysteine) peptidase inhibitor, clade E, member 1	Mus musculus	56-61	
18813358-7	2008	Concordantly, silencing of PAI-1 by RNA interference in wild type fibrosarcoma cells decreased the level of active Akt, and this was accompanied by a sensitization of the cells to etoposide-induced cell death.	Etoposide	180-189	serine (or cysteine) peptidase inhibitor, clade E, member 1	Mus musculus	27-32	
18813358-8	2008	Altogether, our data suggest that PAI-1 influences sensitivity to etoposide-induced apoptosis through the PI3K/Akt cell survival pathway by acting upstream of PI3K and Akt.	Etoposide	66-75	serine (or cysteine) peptidase inhibitor, clade E, member 1	Mus musculus	34-39	
15862760-5	2005	PAI-1 gene-deficient and wild-type mice displayed similar sensitivity to treatment with etoposide, suggesting a differential effect of PAI-1 expression between cancer cells and normal cells.	Etoposide	88-97	serine (or cysteine) peptidase inhibitor, clade E, member 1	Mus musculus	0-5